Abstract
Proteoglycans (PGs), glycosaminoglycans (GAGs) and hyaluronan as a free GAG, have unique structural characteristics which enable them via specific interactions with matrix proteins and cell surface receptors to regulate key tumor cell functions and thus to affect cancer growth and progression. This article explores the many layers of interdependent signaling among transformed colon epithelial cells, neighboring stromal cells and their respective PGs / GAGs components along the insidious and often deadly route of colon cancer progression. Specifically addressed is the altered deposition of PGs / GAGs by colon cancer cells; the effects of these malignant cells on gene expression and biosynthesis of PGs / GAGs of the surrounding stromal cells and the signaling pathways involved, with the utmost goal to highlight potential therapeutic targets in the rapidly developing field of glycan-based therapy.
Keywords: Colorectal cancer, glycosaminoglycans, proteoglycans, therapeutic targets, tumor cell signaling, hyaluronan, chondroitin sulfate, heparan sulfate, metastasis, glycan-based therapy
Current Medicinal Chemistry
Title:Insights into Targeting Colon Cancer Cell Fate at the Level of Proteoglycans / Glycosaminoglycans
Volume: 19 Issue: 25
Author(s): D. Nikitovic, G. Chatzinikolaou, J. Tsiaoussis, A. Tsatsakis, N. K. Karamanos and G. N. Tzanakakis
Affiliation:
Keywords: Colorectal cancer, glycosaminoglycans, proteoglycans, therapeutic targets, tumor cell signaling, hyaluronan, chondroitin sulfate, heparan sulfate, metastasis, glycan-based therapy
Abstract: Proteoglycans (PGs), glycosaminoglycans (GAGs) and hyaluronan as a free GAG, have unique structural characteristics which enable them via specific interactions with matrix proteins and cell surface receptors to regulate key tumor cell functions and thus to affect cancer growth and progression. This article explores the many layers of interdependent signaling among transformed colon epithelial cells, neighboring stromal cells and their respective PGs / GAGs components along the insidious and often deadly route of colon cancer progression. Specifically addressed is the altered deposition of PGs / GAGs by colon cancer cells; the effects of these malignant cells on gene expression and biosynthesis of PGs / GAGs of the surrounding stromal cells and the signaling pathways involved, with the utmost goal to highlight potential therapeutic targets in the rapidly developing field of glycan-based therapy.
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Nikitovic D., Chatzinikolaou G., Tsiaoussis J., Tsatsakis A., Karamanos N. K. and Tzanakakis G. N., Insights into Targeting Colon Cancer Cell Fate at the Level of Proteoglycans / Glycosaminoglycans, Current Medicinal Chemistry 2012; 19 (25) . https://dx.doi.org/10.2174/092986712802884268
DOI https://dx.doi.org/10.2174/092986712802884268 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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