Abstract
Background: In addition to the considerable number of different chlorophyll structures originated naturally, prominent research is made to produce new specific semisynthetic structures. The final target is to obtain chlorophyll derivatives with even better bioactive properties than those of the natural parent compounds.
Method: A detailed, extensive and critic literature search has been made in Web of Science™.
Results: Great efforts are applying to optimize the function of chlorophyll-based photosensitizers, to understand the molecular mechanisms of the antioxidant and antigenotoxic properties of chlorophyll derivatives and, lastly, to investigate new biological actions of them. However, the fundamental physiological functions of the chlorophylls are their physicochemical properties.
Conclusion: This review aims to reflect the chemical grounds of the healthy and/or medical features of chlorophylls, including the consequences, advantages or even new actions that modifications over the chlorophyll structure introduce. Finally, new perspectives in the functionality of chlorophylls at molecular level are discussed.
Keywords: Antigenotoxic, antimutagenic, antioxidant properties, bioactivity, chemical modifications, chlorophylls, functionality, structure.
Current Medicinal Chemistry
Title:Chemistry in the Bioactivity of Chlorophylls: An Overview
Volume: 24 Issue: 40
Author(s): Antonio Perez-Galvez , Isabel Viera and Maria Roca *
Affiliation:
- Food Phytochemistry Department, Instituto de la Grasa, Consejo Superior de Investigaciones Científicas (CSIC), University Campus Pablo de Olavide, Building 46, Carretera de Utrera km. 1, Sevilla 41013,Spain
Keywords: Antigenotoxic, antimutagenic, antioxidant properties, bioactivity, chemical modifications, chlorophylls, functionality, structure.
Abstract: Background: In addition to the considerable number of different chlorophyll structures originated naturally, prominent research is made to produce new specific semisynthetic structures. The final target is to obtain chlorophyll derivatives with even better bioactive properties than those of the natural parent compounds.
Method: A detailed, extensive and critic literature search has been made in Web of Science™.
Results: Great efforts are applying to optimize the function of chlorophyll-based photosensitizers, to understand the molecular mechanisms of the antioxidant and antigenotoxic properties of chlorophyll derivatives and, lastly, to investigate new biological actions of them. However, the fundamental physiological functions of the chlorophylls are their physicochemical properties.
Conclusion: This review aims to reflect the chemical grounds of the healthy and/or medical features of chlorophylls, including the consequences, advantages or even new actions that modifications over the chlorophyll structure introduce. Finally, new perspectives in the functionality of chlorophylls at molecular level are discussed.
Export Options
About this article
Cite this article as:
Perez-Galvez Antonio , Viera Isabel and Roca Maria *, Chemistry in the Bioactivity of Chlorophylls: An Overview, Current Medicinal Chemistry 2017; 24 (40) . https://dx.doi.org/10.2174/0929867324666170714102619
DOI https://dx.doi.org/10.2174/0929867324666170714102619 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Nuclear Magnetic Resonance Spectroscopy and Genetic Disorders
Current Medicinal Chemistry Astrocytes: Adhesion Molecules and Immunomodulation
Current Drug Targets Immune Cell Entry to Central Nervous System - Current Understanding and Prospective Therapeutic Targets
Endocrine, Metabolic & Immune Disorders - Drug Targets Nonstandard Drugs and Feasible New Interventions for Autoimmune Hepatitis: Part II
Inflammation & Allergy - Drug Targets (Discontinued) Antagonism of Eosinophil Accumulation in Asthma
Recent Patents on Inflammation & Allergy Drug Discovery Challenges in Diagnosing Cerebral Lacunar Infarcts
Current Medical Imaging Emerging Therapies in Relapsing-Remitting Multiple Sclerosis
Reviews on Recent Clinical Trials Gene Expression Suggests Spontaneously Hypertensive Rats May Have Altered Metabolism and Reduced Hypoxic Tolerance
Current Neurovascular Research Brain Structural Effects of Antidepressant Treatment in Major Depression
Current Neuropharmacology The Pathology Induced by Highly Active Antiretroviral Therapy Against Human Immunodeficiency Virus: an Update
Current Medicinal Chemistry Pharmacological Targeting of IDO-Mediated Tolerance for Treating Autoimmune Disease
Current Drug Metabolism RAGE, Diabetes, and the Nervous System
Current Molecular Medicine Uncontrolled Hypertension and Oncology: Clinical Tips
Current Vascular Pharmacology Is There Any Scientific Basis of Hawan to be Used in the Alzheimer’s Disease Prevention/Cure?
Current Traditional Medicine The Cytokine Network in HIV Infection
Current Molecular Medicine Plasmodium Drug Targets Outside the Genetic Control of the Parasite
Current Pharmaceutical Design The HLA Region and Autoimmune Disease: Associations and Mechanisms of Action
Current Genomics The Offer of Chemistry to Targeted Therapy in Cancer
Recent Patents on Biotechnology Opiate Drug Use and the Pathophysiology of NeuroAIDS
Current HIV Research CEST MRI for Molecular Imaging of Brain Metabolites
Current Molecular Imaging (Discontinued)