Targeted Drug Delivery Based on Gold Nanoparticle Derivatives

Mazaher       Gholipourmalekabadi; Mohammadmahdi       Mobaraki; Maryam       Ghaffari; Amir       Zarebkohan; Vahid    Fallah   Omrani; Aleksandra    M.    Urbanska; Alexander       Seifalian

doi:10.2174/1381612823666170419105413

Abstract

Drug delivery systems are effective and attractive methods which allow therapeutic substances to be introduced into the body more effectively and safe by having tunable delivery rate and release target site. Gold nanoparticles (AuNPs) have a myriad of favorable physical, chemical, optical, thermal and biological properties that make them highly suitable candidates as non-toxic carriers for drug and gene delivery. The surface modifications of AuNPs profoundly improve their circulation, minimize aggregation rates, enhance attachment to therapeutic molecules and target agents due to their nano range size which further increases their ability to cross cell membranes and reduce overall cytotoxicity. This comprehensive article reviews the applications of the AuNPs in drug delivery systems along with their corresponding surface modifications. The highlighting results obtained from the preclinical trial are promising and next five years have huge possibility move to the clinical setting.

Keywords: Gold nanoparticle, targeted delivery, drug delivery, nanoparticles, surface modification, nanotechnology.

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Current Pharmaceutical Design

Title:Targeted Drug Delivery Based on Gold Nanoparticle Derivatives

Volume: 23 Issue: 20

Author(s): Mazaher Gholipourmalekabadi*, Mohammadmahdi Mobaraki, Maryam Ghaffari, Amir Zarebkohan, Vahid Fallah Omrani, Aleksandra M. Urbanska and Alexander Seifalian*

Affiliation:

Department of Tissue Engineering & Regenerative Medicine, Iran University of Medical Sciences, Hemmat Highway, Tehran,Iran

Nanotechnology and Regenerative Medicine Ltd, The London BioScience Innovation Centre, London,United Kingdom

Keywords: Gold nanoparticle, targeted delivery, drug delivery, nanoparticles, surface modification, nanotechnology.

Abstract: Drug delivery systems are effective and attractive methods which allow therapeutic substances to be introduced into the body more effectively and safe by having tunable delivery rate and release target site. Gold nanoparticles (AuNPs) have a myriad of favorable physical, chemical, optical, thermal and biological properties that make them highly suitable candidates as non-toxic carriers for drug and gene delivery. The surface modifications of AuNPs profoundly improve their circulation, minimize aggregation rates, enhance attachment to therapeutic molecules and target agents due to their nano range size which further increases their ability to cross cell membranes and reduce overall cytotoxicity. This comprehensive article reviews the applications of the AuNPs in drug delivery systems along with their corresponding surface modifications. The highlighting results obtained from the preclinical trial are promising and next five years have huge possibility move to the clinical setting.

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Gholipourmalekabadi Mazaher *, Mobaraki Mohammadmahdi , Ghaffari Maryam , Zarebkohan Amir, Omrani Fallah Vahid , Urbanska M. Aleksandra and Seifalian Alexander *, Targeted Drug Delivery Based on Gold Nanoparticle Derivatives, Current Pharmaceutical Design 2017; 23 (20) . https://dx.doi.org/10.2174/1381612823666170419105413

DOI https://dx.doi.org/10.2174/1381612823666170419105413	Print ISSN 1381-6128
Publisher Name Bentham Science Publisher	Online ISSN 1873-4286

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