Abstract
T cells have originally occupied central stage of the debate on the type of lymphocytes governing the pathogenesis of Sjögren’s syndrome (SS). However, B cells has since been substituted for T cells, and insights into their functions have revealed that they accomplish various tasks. Beyond the paradigm that T lymphocytes maintain strict control over B lymphocytes, these latter cells solicit their own help from the former, release a flurry of cytokines, and act as antigen- presenting cells. In SS, excessive of the B cell-activating factor (BAFF) may cause B-cell quantitative anomalies, such as inflation of mature B (Bm)2/Bm2’ cells in the circulation, or accumulation of transitional type 2, marginal zone (MZ) and memory B cells within the exocrine gland infiltrates. These excesses are also associated with B-cell qualitative anomalies, such as the internal synthesis of BAFF, and a default mechanism that promotes the autoantibody production in ectopic germinal centers or MZ equivalents. Thus, SS should rather be conceived as a quintessential model for B cellinduced autoimmunity. Such a view opens novel prospects for treatment, and indeed B cell-ablative therapy has already been shown to be beneficial to these patients.
Keywords: B lymphocyte, Sjogren's syndrome, B cell activating factor, ectopic germinal centers, T cells, pathogenesis, lymphocytes, cytokines, antigen-presenting cells, marginal zone, internal synthesis, MZ equivalents, B cell-ablative therapy, salyvary gland (SG), rheumatoid arthritis (RA).
Current Pharmaceutical Biotechnology
Title:B-Lymphocytes Govern the Pathogenesis of Sjogren's Syndrome
Volume: 13 Issue: 10
Author(s): Pierre Youinou, Alain Saraux and Jacques-Olivier Pers
Affiliation:
Keywords: B lymphocyte, Sjogren's syndrome, B cell activating factor, ectopic germinal centers, T cells, pathogenesis, lymphocytes, cytokines, antigen-presenting cells, marginal zone, internal synthesis, MZ equivalents, B cell-ablative therapy, salyvary gland (SG), rheumatoid arthritis (RA).
Abstract: T cells have originally occupied central stage of the debate on the type of lymphocytes governing the pathogenesis of Sjögren’s syndrome (SS). However, B cells has since been substituted for T cells, and insights into their functions have revealed that they accomplish various tasks. Beyond the paradigm that T lymphocytes maintain strict control over B lymphocytes, these latter cells solicit their own help from the former, release a flurry of cytokines, and act as antigen- presenting cells. In SS, excessive of the B cell-activating factor (BAFF) may cause B-cell quantitative anomalies, such as inflation of mature B (Bm)2/Bm2’ cells in the circulation, or accumulation of transitional type 2, marginal zone (MZ) and memory B cells within the exocrine gland infiltrates. These excesses are also associated with B-cell qualitative anomalies, such as the internal synthesis of BAFF, and a default mechanism that promotes the autoantibody production in ectopic germinal centers or MZ equivalents. Thus, SS should rather be conceived as a quintessential model for B cellinduced autoimmunity. Such a view opens novel prospects for treatment, and indeed B cell-ablative therapy has already been shown to be beneficial to these patients.
Export Options
About this article
Cite this article as:
Youinou Pierre, Saraux Alain and Pers Jacques-Olivier, B-Lymphocytes Govern the Pathogenesis of Sjogren's Syndrome, Current Pharmaceutical Biotechnology 2012; 13 (10) . https://dx.doi.org/10.2174/138920112802273100
DOI https://dx.doi.org/10.2174/138920112802273100 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
Latest Advancements in Biotherapeutics
The scope of this thematic issue is to comprehensively explore the rapidly evolving landscape of biotherapeutics, emphasizing breakthroughs in precision medicine. Encompassing diverse therapeutic modalities, the issue will delve into the latest developments in monoclonal antibodies, CRISPR/Cas gene editing, CAR-T cell therapies, and innovative drug delivery systems, such as nanoparticle-based ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
TLR7/9 Antagonists as Therapeutics for Immune-Mediated Inflammatory Disorders
Inflammation & Allergy - Drug Targets (Discontinued) The Role of Chloroquine and Hydroxychloroquine in Immune Regulation and Diseases
Current Pharmaceutical Design A Common Pathway for All Autoimmune Diseases? The Unholy Alliance of Environment, Cell Death and Nucleic Acids
Current Immunology Reviews (Discontinued) Coexistance of Amyloidosis and Primary Sjögren's Syndrome: An Overview
Current Rheumatology Reviews From Molecular Mechanism to the Etiology of Sjogren Syndrome
Current Pharmaceutical Design Migraine in Systemic Autoimmune Diseases
Endocrine, Metabolic & Immune Disorders - Drug Targets Vaccination and Rheumatic Diseases: Is There Still a Dilemma?
Current Rheumatology Reviews Selenium and Autoimmune Diseases: A Review Article
Current Rheumatology Reviews Anti-CD20 Antibody in Primary Sjogren's Syndrome Managemen
Current Pharmaceutical Biotechnology Sjogrens Syndrome and Lymphoma Development
Current Immunology Reviews (Discontinued) Neurological Involvement as the Initial Manifestation in Primary Sjögren's Syndrome - A Case Report
Current Rheumatology Reviews Current Status of Molecular Imaging in Inflammatory and Autoimmune Disorders
Current Pharmaceutical Design Mikuliczs Disease and its Extraglandular Lesions
Current Immunology Reviews (Discontinued) Pleural Involvement in Systemic Disorders
Current Drug Targets - Inflammation & Allergy Molecular Characteristics of Autoimmune Pancreatitis
Current Pharmaceutical Design Rheumatoid Arthritis Patients with Sjogrens Syndrome are More Prone to Depression than Patients with Rheumatoid Arthritis or Sjogrens Syndrome Alone
Current Rheumatology Reviews Mixed Connective Tissue Disease (MCTD) and Undifferentiated Connective Tissue Disease (UCTD)
Current Rheumatology Reviews New Organ-Specific Pharmacological Strategies Interfering With Signaling Pathways In Inflammatory Disorders/Autoimmune Disorders
Current Signal Transduction Therapy Cardiovascular Disease in Primary Sjögren’s Syndrome
Reviews on Recent Clinical Trials Interstitial Lung Disease in Sjogrens Syndrome
Current Rheumatology Reviews