Abstract
The emergence of bacteria resistance to most of the currently available antibiotics has become a critical therapeutic problem. The bacteria causing both hospital and community-acquired infections are most often multidrug resistant. In view of the alarming level of antibiotic resistance between bacterial species and difficulties with treatment, alternative or supportive antibacterial cure has to be developed. The presented review focuses on the major characteristics of bacteriophages and phage-encoded proteins affecting their usefulness as antimicrobial agents. We discuss several issues such as mode of action, pharmacodynamics, pharmacokinetics, resistance and manufacturing aspects of bacteriophages and phage-encoded proteins application.
Keywords: antibiotics, bacterial multidrug resistance, bacteriophage therapy, phage-encoded proteins application, Bacteriophages, ANTIMICROBIAL DRUG RESISTANCE, Bacterial Anti-Phage Resistance, PHAGE-ENCODED PROTEINS, EPS- Degrading Phage Enzymes, Bacterial Protein Synthesis
Current Protein & Peptide Science
Title:Learning from Bacteriophages - Advantages and Limitations of Phage and Phage-Encoded Protein Applications
Volume: 13 Issue: 8
Author(s): Zuzanna Drulis-Kawa, Grazyna Majkowska-Skrobek, Barbara Maciejewska, Anne-Sophie Delattre and Rob Lavigne
Affiliation:
Keywords: antibiotics, bacterial multidrug resistance, bacteriophage therapy, phage-encoded proteins application, Bacteriophages, ANTIMICROBIAL DRUG RESISTANCE, Bacterial Anti-Phage Resistance, PHAGE-ENCODED PROTEINS, EPS- Degrading Phage Enzymes, Bacterial Protein Synthesis
Abstract: The emergence of bacteria resistance to most of the currently available antibiotics has become a critical therapeutic problem. The bacteria causing both hospital and community-acquired infections are most often multidrug resistant. In view of the alarming level of antibiotic resistance between bacterial species and difficulties with treatment, alternative or supportive antibacterial cure has to be developed. The presented review focuses on the major characteristics of bacteriophages and phage-encoded proteins affecting their usefulness as antimicrobial agents. We discuss several issues such as mode of action, pharmacodynamics, pharmacokinetics, resistance and manufacturing aspects of bacteriophages and phage-encoded proteins application.
Export Options
About this article
Cite this article as:
Drulis-Kawa Zuzanna, Majkowska-Skrobek Grazyna, Maciejewska Barbara, Delattre Anne-Sophie and Lavigne Rob, Learning from Bacteriophages - Advantages and Limitations of Phage and Phage-Encoded Protein Applications, Current Protein & Peptide Science 2012; 13 (8) . https://dx.doi.org/10.2174/138920312804871193
DOI https://dx.doi.org/10.2174/138920312804871193 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
Call for Papers in Thematic Issues
Advancements in Proteomic and Peptidomic Approaches in Cancer Immunotherapy: Unveiling the Immune Microenvironment
The scope of this thematic issue centers on the integration of proteomic and peptidomic technologies into the field of cancer immunotherapy, with a particular emphasis on exploring the tumor immune microenvironment. This issue aims to gather contributions that illustrate the application of these advanced methodologies in unveiling the complex interplay ...read more
Artificial Intelligence for Protein Research
Protein research, essential for understanding biological processes and creating therapeutics, faces challenges due to the intricate nature of protein structures and functions. Traditional methods are limited in exploring the vast protein sequence space efficiently. Artificial intelligence (AI) and machine learning (ML) offer promising solutions by improving predictions and speeding up ...read more
Nutrition and Metabolism in Musculoskeletal Diseases
The musculoskeletal system consists mainly of cartilage, bone, muscles, tendons, connective tissue and ligaments. Balanced metabolism is of vital importance for the homeostasis of the musculoskeletal system. A series of musculoskeletal diseases (for example, sarcopenia, osteoporosis) are resulted from the dysregulated metabolism of the musculoskeletal system. Furthermore, metabolic diseases (such ...read more
Protein Folding, Aggregation and Liquid-Liquid Phase Separation
Protein folding, misfolding and aggregation remain one of the main problems of interdisciplinary science not only because many questions are still open, but also because they are important from the point of view of practical application. Protein aggregation and formation of fibrillar structures, for example, is a hallmark of a ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Advanced PLS Techniques in Chemoinformatics Studies
Current Computer-Aided Drug Design Tubercidin and Related Analogues: An Inspiration for 50 years in Drug Discovery
Current Organic Chemistry Meet Our Editorial Board Member
Reviews on Recent Clinical Trials The Role of Bacteria and Viruses in Chronic Obstructive Pulmonary Disease
Current Respiratory Medicine Reviews Synthesis and Preliminary Screening of Novel Tryptamines as 5-HT4 Receptor Ligands
Current Medicinal Chemistry A Comparative Analysis of Protein Interfaces
Protein & Peptide Letters Discovery of Small Molecules that Target Autophagy for Cancer Treatment
Current Medicinal Chemistry New Insights into the Regulation of Liver Inflammation and Oxidative Stress
Mini-Reviews in Medicinal Chemistry Cyclopentane Sesquiterpenes from Fungi: Ocurrence-Bioactivity, Biosynthesis and Chemical Synthesis
Current Organic Chemistry Bioactive Coumarins from Marine Sources: Origin, Structural Features and Pharmacological Properties
Current Topics in Medicinal Chemistry α-Glucosidase Inhibition and Docking Studies of 5-Deoxyflavonols and Dihydroflavonols Isolated from Abutilon pakistanicum
Current Organic Chemistry Irreversible Protein Kinase Inhibitors
Current Medicinal Chemistry Macrocyclic Hepatitis C Virus NS3/4A Protease Inhibitors: An Overview of Medicinal Chemistry
Current Medicinal Chemistry The Echinocandins: Total and Semi-Synthetic Approaches in Antifungal Drug Discovery
Anti-Infective Agents in Medicinal Chemistry Recent Developments in Patents Targeting Toll-Like Receptor Genes
Recent Patents on DNA & Gene Sequences Modular Nanotransporters for Targeted Intracellular Delivery of Drugs: Folate Receptors as Potential Targets
Current Pharmaceutical Design Cellular Changes, Molecular Pathways and the Immune System Following Photodynamic Treatment
Current Medicinal Chemistry 3,4-DHQLO and Triazole and Its Related Analogues with Anticonvulsant Effects
Mini-Reviews in Medicinal Chemistry Anti-Tumor Effects of Osthole on Different Malignant Tissues: A Review of Molecular Mechanisms
Anti-Cancer Agents in Medicinal Chemistry Recent Advances in the Synthesis of Biologically Active Cinnoline, Phthalazine and Quinoxaline Derivatives
Current Organic Chemistry