Abstract
The chemistry of 1,3,4-thiadiazoles is very well known. A universal and commonly used method of the synthesis of different 2,5-disubstituted 1,3,4-thiadiazoles includes the cyclization of appropriate linear organic derivatives. They are widely known as compounds with various kinds of biological activities showing anticancer properties against human cancers and acting as diuretic, antibacterial, antifungal, antitubercular and leishmanicidal agents. Many of them influence on OUN exhibiting anticonvulsant, anti-inflammatory, antidepressant, analgesic and anxiolytic effects. The molecular target of 1,3,4-thiadiazoles includes the following enzymes: carbonic anhydrase (CA), cyclooxygenase (CO), neutral endopeptidase (NEP), aminopeptidase N (APN), matrix metalloproteinases (MMPs), phosphodiesterases (PDEs) and c-Src/Abl tyrosine kinase. In this presentation, recent achievements in the medicinal chemistry of 1,3,4-thiadiazole based compounds are reviewed.
Keywords: Anticancer agents, anticonvulsant activity, carbonic anhydrase inhibitors, cyclooxygenase inhibitors, diuretics, leishmanicidal agents, metalloproteinases inhibitors, 1, 3, 4-thiadiazoles.
Mini-Reviews in Medicinal Chemistry
Title:Biological and Pharmacological Activities of 1,3,4-Thiadiazole Based Compounds
Volume: 15 Issue: 9
Author(s): Joanna Matysiak
Affiliation:
Keywords: Anticancer agents, anticonvulsant activity, carbonic anhydrase inhibitors, cyclooxygenase inhibitors, diuretics, leishmanicidal agents, metalloproteinases inhibitors, 1, 3, 4-thiadiazoles.
Abstract: The chemistry of 1,3,4-thiadiazoles is very well known. A universal and commonly used method of the synthesis of different 2,5-disubstituted 1,3,4-thiadiazoles includes the cyclization of appropriate linear organic derivatives. They are widely known as compounds with various kinds of biological activities showing anticancer properties against human cancers and acting as diuretic, antibacterial, antifungal, antitubercular and leishmanicidal agents. Many of them influence on OUN exhibiting anticonvulsant, anti-inflammatory, antidepressant, analgesic and anxiolytic effects. The molecular target of 1,3,4-thiadiazoles includes the following enzymes: carbonic anhydrase (CA), cyclooxygenase (CO), neutral endopeptidase (NEP), aminopeptidase N (APN), matrix metalloproteinases (MMPs), phosphodiesterases (PDEs) and c-Src/Abl tyrosine kinase. In this presentation, recent achievements in the medicinal chemistry of 1,3,4-thiadiazole based compounds are reviewed.
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Cite this article as:
Matysiak Joanna, Biological and Pharmacological Activities of 1,3,4-Thiadiazole Based Compounds, Mini-Reviews in Medicinal Chemistry 2015; 15 (9) . https://dx.doi.org/10.2174/1389557515666150519104057
DOI https://dx.doi.org/10.2174/1389557515666150519104057 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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