Abstract
Chitosan is a linear amino-polysaccharide and a natural polymer with a structure based on repetitive deacetylated and acetylated units randomly distributed. It is produced from chitin, one of the most common naturally occurring polysaccharides. Its numerous biomedical applications have been extensively described in the literature. It becomes more and more popular as a therapeutic agent and its use is constantly extended. Given its commonness, regenerative properties, easy chemical treatment, and biocompatibility, it might be used in the treatment of damaged oral cavity tissues. Due to its antimicrobial and regenerative-inducting properties as well as high biocompetency, chitosan is more and more frequently used in medicine and dentistry. It can be applied in all fields of dentistry including preventive dentistry, conservative dentistry, endodontics, surgery, periodontology, prosthodontics and orthodontics. Several data discussing the effectiveness of chitosan use on new bone formation are still inconclusive. The aim of the paper was to evaluate the applicability and biochemical impact of chitosan on oral health maintenance. Even though chitosan might find its adhibition in all dental specialities, it should still be considered as a potential allergen and thus further studies on this topic should be carried out.
Keywords: Biocompatibility, chitosan, dentistry, oral health, polysaccharide, treatment.
Mini-Reviews in Medicinal Chemistry
Title:Clinical Application of Chitosan in Dental Specialities
Volume: 17 Issue: 5
Author(s): Mieszko Wieckiewicz, Klaus W. Boening, Natalia Grychowska and Anna Paradowska-Stolarz
Affiliation:
Keywords: Biocompatibility, chitosan, dentistry, oral health, polysaccharide, treatment.
Abstract: Chitosan is a linear amino-polysaccharide and a natural polymer with a structure based on repetitive deacetylated and acetylated units randomly distributed. It is produced from chitin, one of the most common naturally occurring polysaccharides. Its numerous biomedical applications have been extensively described in the literature. It becomes more and more popular as a therapeutic agent and its use is constantly extended. Given its commonness, regenerative properties, easy chemical treatment, and biocompatibility, it might be used in the treatment of damaged oral cavity tissues. Due to its antimicrobial and regenerative-inducting properties as well as high biocompetency, chitosan is more and more frequently used in medicine and dentistry. It can be applied in all fields of dentistry including preventive dentistry, conservative dentistry, endodontics, surgery, periodontology, prosthodontics and orthodontics. Several data discussing the effectiveness of chitosan use on new bone formation are still inconclusive. The aim of the paper was to evaluate the applicability and biochemical impact of chitosan on oral health maintenance. Even though chitosan might find its adhibition in all dental specialities, it should still be considered as a potential allergen and thus further studies on this topic should be carried out.
Export Options
About this article
Cite this article as:
Wieckiewicz Mieszko, Boening W. Klaus, Grychowska Natalia and Paradowska-Stolarz Anna, Clinical Application of Chitosan in Dental Specialities, Mini-Reviews in Medicinal Chemistry 2017; 17 (5) . https://dx.doi.org/10.2174/1389557516666160418123054
DOI https://dx.doi.org/10.2174/1389557516666160418123054 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
Natural Products in Drug Discovery
Natural products have always been one of the important ways of drug discovery due to their novel skeleton and diverse functional group characteristics. According to statistics, between 1981 and 2019, the FDA approved a total of 1,394 small molecule drugs for marketing, of which 930 marketed drugs originated from the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Cervical Cancer and Human Papillomaviruses: Inactivation of Retinoblastoma and Other Tumor Suppressor Pathways
Current Molecular Medicine Control of Protein Synthesis in Malignant Transformation - the Role of eIF4E and the eIF4E Binding Proteins in the Regulation of Apoptosis
Current Cancer Therapy Reviews New Cathepsin D Inhibitor Library Utilizing Hydroxyethyl Isosteres with Cyclic Tertiary Amines
Medicinal Chemistry Impact of Curcumin on Microsomal Enzyme Activities: Drug Interaction and Chemopreventive Studies
Current Medicinal Chemistry Toward The Rational Design of Cell Fate Modifiers Notch Signaling as a Target for Novel Biopharmaceuticals
Current Pharmaceutical Biotechnology Performance Analysis of Brain Tumor Detection based on Fuzzy Logic and Neural Network Classifier
Current Medical Imaging Patent Selections
Recent Patents on Anti-Cancer Drug Discovery Silymarin Extends Lifespan and Reduces Proteotoxicity in C. elegans Alzheimer’s Model
CNS & Neurological Disorders - Drug Targets Progress in the Discovery of Polo-like Kinase Inhibitors
Current Topics in Medicinal Chemistry Pyrrolo[1,2-a]azepines Coupled with Benzothiazole and Fluorinated Aryl Thiourea Scaffolds as Promising Antioxidant and Anticancer Agents
Anti-Cancer Agents in Medicinal Chemistry The Anticancer Properties of Dietary Polyphenols and its Relation with Apoptosis
Current Pharmaceutical Design Folic Acid Conjugated Chitosan Nanoparticles for Tumor Targeting of Therapeutic and Imaging Agents
Pharmaceutical Nanotechnology A Systematic in-silico Analysis of Helicobacter pylori Pathogenic Islands for Identification of Novel Drug Target Candidates
Current Genomics Reversal of Bone Cancer Pain by HSV-1-Mediated Silencing of CNTF in an Afferent Area of the Spinal Cord Associated with AKT-ERK Signal Inhibition
Current Gene Therapy A Comparative Study of Glucose and Fructose in the Development of Sarcoma 180 in Mice
Letters in Organic Chemistry DNA Repair Proteins as Molecular Targets for Cancer Therapeutics
Anti-Cancer Agents in Medicinal Chemistry Advancement of Targeted Ultrasound Contrast Agents and their Applications in Molecular Imaging and Targeted Therapy
Current Pharmaceutical Design Opportunities and Challenges for Host-Directed Therapies in Tuberculosis
Current Pharmaceutical Design Oral Inflammation and Bacteremia: Implications for Chronic and Acute Systemic Diseases Involving Major Organs
Cardiovascular & Hematological Disorders-Drug Targets Tracking Cell Signaling Protein Expression and Phosphorylation by Innovative Proteomic Solutions
Current Pharmaceutical Biotechnology