Abstract
Although some functional activities of interleukin (IL)-15 on NK and T cells overlap with those of IL-2, recent findings obtained from gene-targeted mice deficient in components of IL-2 / IL-15 system demonstrate distinct roles of IL-15 for the activation of innate immune system. IL-15 is a pivotal cytokine for the development and survival of NK cells, NKT cells, TCRγδ+ intestinal intraepithelial lymphocytes (iIEL), and for the functional maturation of dendritic cells and macrophages. IL-15 is also important for memory T cell maintenance in vivo. In this review, I summarize recent progress of studies in the IL-15 / IL-15R system.
Keywords: il-15, il-2, innate immunity, iel, il-15/il-15r
Current Molecular Medicine
Title: Critical Role for IL-15 in Innate Immunity
Volume: 2 Issue: 4
Author(s): Toshiaki Ohteki
Affiliation:
Keywords: il-15, il-2, innate immunity, iel, il-15/il-15r
Abstract: Although some functional activities of interleukin (IL)-15 on NK and T cells overlap with those of IL-2, recent findings obtained from gene-targeted mice deficient in components of IL-2 / IL-15 system demonstrate distinct roles of IL-15 for the activation of innate immune system. IL-15 is a pivotal cytokine for the development and survival of NK cells, NKT cells, TCRγδ+ intestinal intraepithelial lymphocytes (iIEL), and for the functional maturation of dendritic cells and macrophages. IL-15 is also important for memory T cell maintenance in vivo. In this review, I summarize recent progress of studies in the IL-15 / IL-15R system.
Export Options
About this article
Cite this article as:
Ohteki Toshiaki, Critical Role for IL-15 in Innate Immunity, Current Molecular Medicine 2002; 2 (4) . https://dx.doi.org/10.2174/1566524023362519
DOI https://dx.doi.org/10.2174/1566524023362519 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Proteomic Approach in the Development of Prognostic Biomarkers in Atherothrombosis
Recent Patents on Cardiovascular Drug Discovery B-Cells and the Use of Non-Human Primates for Evaluation of HIV Vaccine Candidates
Current HIV Research Augmentation Therapy with Alpha1-antitrypsin: Novel Perspectives
Cardiovascular & Hematological Disorders-Drug Targets Explore on the Mechanism of miRNA-146a/TAB1 in the Regulation of Cellular Apoptosis and Inflammation in Ulcerative Colitis Based on NF-κB Pathway
Current Molecular Medicine Healthy Diet, Grape Phytochemicals, and Vitamin D: Preventing Chronic Inflammation and Keeping Good Microbiota
Endocrine, Metabolic & Immune Disorders - Drug Targets Anti-Inflammatory Drugs and Prediction of New Structures by Comparative Analysis
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Separating Fact from Fiction: Assessing the Potential of Modified Adenovirus Vectors for Use in Human Gene Therapy
Current Gene Therapy Symptoms, Diagnosis, and Treatment of Cow's Milk Allergy
Current Pediatric Reviews Evaluation of B Lymphocyte Deficiencies
Cardiovascular & Hematological Disorders-Drug Targets The Immunopathy of Alzheimer’s Disease: Innate or Adaptive?
Current Alzheimer Research Editorial [Hot Topic: Targeting Mast Cells and Basophils in Allergy and Beyond: Emerging Concepts (Executive Guest Editor: Petr Heneberg)]
Current Pharmaceutical Design Neurovascular Changes in Acute, sub-Acute and Chronic Mouse Models of Parkinson’s Disease
Current Neurovascular Research Three Dimensional Molecular Field Analysis of Thiomorpholine Analogs of TACE Inhibitors Using Receptor Based Alignment
Letters in Drug Design & Discovery Antiviral Activity Of Ribosome Inactivating Proteins In Medicine
Mini-Reviews in Medicinal Chemistry The Role of Epidermal Growth Factor Receptor in the Management of Gastrointestinal Carcinomas: Present Status and Future Perspectives
Current Pharmaceutical Design Putative Mechanisms of Action and Clinical Use of Lithium in Children and Adolescents: A Critical Review
Current Neuropharmacology Legume Proteins as a Promising Source of Anti-Inflammatory Peptides
Current Protein & Peptide Science Advances in Immunological Treatment of Allergy
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Exploring the Potential of NO-Independent Stimulators and Activators of Soluble Guanylate Cyclase for the Medical Treatment of Erectile Dysfunction
Current Pharmaceutical Design Mammalian Target of Rapamycin as a Therapeutic Target in Leukemia
Current Molecular Medicine