Investigation on the Effects of Antimicrobial imidazo[2,1-b]thiazole Derivatives on the Genitourinary Microflora

Title:Investigation on the Effects of Antimicrobial imidazo[2,1-b]thiazole Derivatives on the Genitourinary Microflora

Volume: 14 Issue: 3

Author(s): Rita Morigi, Beatrice Vitali, Cecilia Prata, Rogers A.N. Palomino, Alessandra Graziadio, Alessandra Locatelli, Mirella Rambaldi and Alberto Leoni*

Affiliation:

• Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126 Bologna,Italy

Keywords: Ampicillin, imidazo[2, 1-b]thiazole, urogenital pathogens, bifidobacteria, lactobacilli, antiproliferative effects.

Abstract: Background: Fused five-membered heterocyclic rings containing bridgehead nitrogen atom are particularly versatile in the field of medicinal chemistry because of their different biological activities. Among them, the imidazo[2,1-b]thiazole is an attractive fused heterocyclic core that has been extensively studied.

Objective: The aim of the current study was to study the therapeutic applications of imidazo[2,1- b]thiazole derivatives as antimicrobial agents for the treatment of genitourinary infections.

Method: A traditional synthetic methodology was involved to obtain a small series of imidazothiazole derivatives.

Results: Herein, we report the antimicrobial activity of the imidazo[2,1-b]thiazole or imidazo[2,1- b]thiazolidine derivatives against selected fungi, Gram-positive and Gram-negative bacteria. Moreover, experiments were carried out to investigate the interference towards the endogenous microbiota.

Conclusion: The most interesting of the series are the thiocyano derivatives (19, 23) showing a good profile for the treatment of genitourinary infections: a spectrum of activity covering both bacteria and fungi together with a reduced impact versus critical lines of Lactobacillus exerting defense against pathogens.

Cite this article as:

Morigi Rita , Vitali Beatrice , Prata Cecilia , Palomino A.N. Rogers , Graziadio Alessandra , Locatelli Alessandra, Rambaldi Mirella and Leoni Alberto*, Investigation on the Effects of Antimicrobial imidazo[2,1-b]thiazole Derivatives on the Genitourinary Microflora, Medicinal Chemistry 2018; 14 (3) . https://dx.doi.org/10.2174/1573406413666171010110819