Abstract
MicroRNAs (miRNAs) are attractive, short, non-coding RNAs widely studied for their fundamental roles in tissue homeostasis, cell proliferation, and dysregulation in cancer. A vast majority of investigations and technical improvements have focused on miRNAs' tumor-specific expression patterns, which provide novel molecular biomarkers for cancer detection and targeted therapies. In this review, we focus on recent achievements in biomarker validation and potential for cancer treatment, with special trend in non-invasive strategies to evaluate miRNAs, especially for diagnostic and prognostic applications. We further include a large compilation of PubMed data regarding microRNAs reported as diagnostic or prognostic cancer biomarkers in at least three studies.
Keywords: Biomarker, cancer, cell-free miRNA, diagnosis, microRNA, prognosis.
MicroRNA
Title:MicroRNAs as Cancer Biomarkers
Volume: 2 Issue: 2
Author(s): Nazila Nouraee and George A. Calin
Affiliation:
Keywords: Biomarker, cancer, cell-free miRNA, diagnosis, microRNA, prognosis.
Abstract: MicroRNAs (miRNAs) are attractive, short, non-coding RNAs widely studied for their fundamental roles in tissue homeostasis, cell proliferation, and dysregulation in cancer. A vast majority of investigations and technical improvements have focused on miRNAs' tumor-specific expression patterns, which provide novel molecular biomarkers for cancer detection and targeted therapies. In this review, we focus on recent achievements in biomarker validation and potential for cancer treatment, with special trend in non-invasive strategies to evaluate miRNAs, especially for diagnostic and prognostic applications. We further include a large compilation of PubMed data regarding microRNAs reported as diagnostic or prognostic cancer biomarkers in at least three studies.
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Cite this article as:
Nouraee Nazila and Calin A. George, MicroRNAs as Cancer Biomarkers, MicroRNA 2013; 2 (2) . https://dx.doi.org/10.2174/22115366113029990015
DOI https://dx.doi.org/10.2174/22115366113029990015 |
Print ISSN 2211-5366 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-5374 |
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