Formulation and Evaluation of Novel Solid Lipid Microparticles for the Sustained Release of Ofloxacin

Title:Formulation and Evaluation of Novel Solid Lipid Microparticles for the Sustained Release of Ofloxacin

Volume: 5 Issue: 4

Author(s): Aashima Hooda*, M. Sradhanjali and Popsy

Affiliation:

• PDM College of Pharmacy, Sector-3A Bahadurgarh, Haryana,India

Keywords: High shear homogenization technique, ofloxacin, solid lipid microparticles, stearic acid, Tween-80.

Abstract: Objective: The aim of this study was to prepare solid lipid microparticles (SLM) with incorporated ofloxacin, suitable for oral delivery.

Methods: Ofloxacin-loaded SLM were prepared using stearic acid and chloroform as lipid matrix and Tween-80 as surfactant, by high shear homogenization technique and followed by lyophilization. The physiochemical characterization of SLMs were investigated by scanning electron microscopy, transmission electron microscopy, zeta potential, zone of inhibition, in-vitro study, ex-vivo study and stability study.

Results: The result demonstrated that the entrapment efficiency, particle size and zeta potential of microparticles were 86.02%, 203.7nm and -32.68mv, respectively. The in-vitro and ex-vivo studies showed sustained release of drug from formulation.

Conclusion: These results indicate that SLM might be a promising delivery system to enhance the pharmacological activity of ofloxacin.

Cite this article as:

Hooda Aashima*, Sradhanjali M. and Popsy , Formulation and Evaluation of Novel Solid Lipid Microparticles for the Sustained Release of Ofloxacin, Pharmaceutical Nanotechnology 2017; 5 (4) . https://dx.doi.org/10.2174/2211738506666171226121720