Role of Prehypertension in the Development of Coronary Atherosclerosis in Japan

Masakazu Washio; Shoji Tokunaga; Kouichi Yoshimasu; Hiroko Kodama; Ying Liu; Shizuka Sasazuki; Keitaro Tanaka; Suminori Kono; Masahiro Mohri; Akira Takeshita; Kikuo Arakawa; Munehito Ideishi; Takanobu Nii; Kazuyuki Shirai; Hidekazu Arai; Yoshitaka Doi; Tomoki Kawano; Osamu Nakagaki; Kazuyuki Takada; Koji Hiyamuta; Samon Koyanagi

doi:10.2188/jea.14.57

Original Article

Role of Prehypertension in the Development of Coronary Atherosclerosis in Japan

Masakazu Washio, Shoji Tokunaga, Kouichi Yoshimasu, Hiroko Kodama, Ying Liu, Shizuka Sasazuki, Keitaro Tanaka, Suminori Kono, Masahiro Mohri, Akira Takeshita, Kikuo Arakawa, Munehito Ideishi, Takanobu Nii, Kazuyuki Shirai, Hidekazu Arai, Yoshitaka Doi, Tomoki Kawano, Osamu Nakagaki, Kazuyuki Takada, Koji Hiyamuta, Samon Koyanagi

Author information

Masakazu Washio
Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University
Shoji Tokunaga
Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University
Kouichi Yoshimasu
Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University
Hiroko Kodama
Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University
Ying Liu
Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University
Shizuka Sasazuki
Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University
Keitaro Tanaka
Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University
Suminori Kono
Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University
Masahiro Mohri
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University
Akira Takeshita
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University
Kikuo Arakawa
Second Department of Internal Medicine, School of Medicine, Fukuoka University
Munehito Ideishi
Second Department of Internal Medicine, School of Medicine, Fukuoka University
Takanobu Nii
Second Department of Internal Medicine, School of Medicine, Fukuoka University
Kazuyuki Shirai
Second Department of Internal Medicine, School of Medicine, Fukuoka University
Hidekazu Arai
Tokushukai Fukuoka Hospital
Yoshitaka Doi
Saiseikai Fukuoka General Hospital
Tomoki Kawano
Saiseikai Fukuoka General Hospital
Osamu Nakagaki
Saiseikai Fukuoka General Hospital
Kazuyuki Takada
Saiseikai Fukuoka General Hospital
Koji Hiyamuta
National Kyushu Medical Center Hospital
Samon Koyanagi
National Kyushu Medical Center Hospital

Keywords: hypertension, coronary arteriosclerosis, risk, Japan

JOURNAL FREE ACCESS

2004 Volume 14 Issue 2 Pages 57-62

DOI https://doi.org/10.2188/jea.14.57

Details

Abstract

BACKGROUND: Hypertension is an important risk factor of coronary heart disease. A new guidelines for hypertension prevention and management in The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure in the United States recommended lifestyle modification or medical treatment for subjects with prehypertension. However, whether prehypertension increases the risk of coronary atherosclerosis in the Japanese population is still unknown.
METHODS: A cross-sectional study in a clinical setting was conducted. The subjects were 705 patients (417 males and 288 females) aged 30 years and older who underwent a first-time coronary angiography for suspected or known coronary heart disease at 5 major cardiology departments in the Fukuoka metropolitan area between September 1996 and August 1997.
RESULTS: Compared to subjects with normal blood pressure, those with prehypertension had an increased risk of coronary atherosclerosis even after adjusting for other factors.
CONCLUSION: Prehypertension may be an important clinical entity which requires treatment in the Japanese population.

Corresponding author

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