doiSerbia

The chemical composition, antimicrobial and antioxidant activities of the essential oil of Salvia fruticosa growing wild in Libya

Giweli Abdulhamid A. (Faculty of Biology, Institute of Botany and Botanical Garden “Jevremovac”, Belgrade + Department of Botany, Faculty of Science, University of Al-Gabel Al-Garbe, Zintan, Libya)
Džamić Ana M. (Faculty of Biology, Institute of Botany and Botanical Garden “Jevremovac”, Belgrade)
Soković Marina (Institute for Biological Research “Siniša Stanković”, Belgrade)
Ristić M.S. (Institute for Medicinal Plant Research “Dr Josif Pančić”, Belgrade)
Janaćković P. (Faculty of Biology, Institute of Botany and Botanical Garden “Jevremovac”, Belgrade)
Marin P.D. (Faculty of Biology, Institute of Botany and Botanical Garden “Jevremovac”, Belgrade)

The composition of essential oil isolated from Salvia fruticosa, wild growing in Libya, was analyzed by GC and GC-MS. Forty-five compounds could be identified. The essential oil contained 1,8-cineole (49.34%), camphor (7.53%), β-pinene (7.38%), myrcene (7.38%), α-pinene (5.15%), β-caryophyllene (4.13%) and α-terpineol (3.25). Antioxidant activity was analyzed using the DPP H free radical scavenging method and low antioxidant activity was found (IC50 = 15.53 mg/ml). The oil was also screened for its antimicrobial activity against eight bacteria (four Gram-negative and four Gram-positive) and eight fungi. The essential oil of S. fruticosa showed minimal inhibitory activity (MIC) at 0.125-1.5 mg/ml and bactericidal (MBC) at 0.5-2.0 mg/ml. In addition, it exhibited fungistatic (MIC) at 0.125-1.0 mg/ml and fungicidal effect (MFC) at 0.125-1.5 mg/ml.

Keywords: Salvia fruticosa, essential oil, antimicrobial, antioxidant activity, 1,8-cineole

Projekat Ministarstva nauke Republike Srbije, br. 173029 and br. 173032