Journal of the Serbian Chemical Society 2012 Volume 77, Issue 1, Pages: 53-66
https://doi.org/10.2298/JSC110328160S
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Spectroscopic properties and antimicrobial activity of dioxomolybdenum(VI) complexes with heterocyclic S,S’-ligands
Sovilj Sofija P. (Faculty of Chemistry, Belgrade)
Mitić Dragana (Faculty of Chemistry, Belgrade)
Drakulić Branko J. (IChTM, Department of Chemistry, Belgrade)
Milenković Marina (Department of Microbiology and Immunology, Faculty of Pharmacy, Belgrade)
Five new dioxomolybdenum(VI) complexes of the general formula[MoO2(Rdtc)2],
1-5, where Rdtc-refer to piperidine- (Pipdtc), 4-morpholine-(Morphdtc),
4-thiomorpholine-(Timdtc), piperazine- (Pzdtc) or Nmethylpiperazine-
(N-Mepzdtc) dithiocarbamates, respectively, have been prepared. Elemental
analysis, conductometric measurements, electronic, IR and NMR spectroscopy
have been employed to characterize them. Complexes 1-5 contain a cis-MoO2
group and are of an octahedral geometry. Two dithiocarbamato ions join as
bidentates with both the sulphur atoms to the molybdenum atom. The presence
of different heteroatom in the piperidinо moiety influences the v(C----N) and
v(C----S) vibrations, which decrease in the order of the complexes with:
Pipdtc > N-Mepipdtc > Morphdtc > Pzdtc > Timdtc ligands. On the basis of
spectral data, molecular structures of complexes 1-5 were optimized on
semiempirical molecular-orbital level, and the geometries, as obtained from
calculations, described. Antimicrobial activity was tested against nine
different laboratory control strains of bacteria and two strains of yeast
Candida albicans. All tested strains were sensitive. Complexes bearing
heteroatom in position 4 of piperidine moiety are significantly more potent
against bacteria tested comparing to corresponding ligands.
Keywords: dithiocarbamates, molybdenum(VI) complexes, MoO22+ group, geometry optimization