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Synthesis and spectroscopic characterization of mononuclear/binuclear organotin(IV) complexes with 1H-1,2,4-triazole-3-thiol: Comparative studies of their antibacterial/antifungal potencies

Parveen Bushra (GC University, Department of Chemistry, Faisalabad, Pakistan)
Bukhari Iftikhar Hussain (GC University, Department of Chemistry, Faisalabad, Pakistan)
Shahzadi Saira (Quaid-i-Azam University, Department of Chemistry, Islamabad, Pakistan)
Ali Saqib (Quaid-i-Azam University, Department of Chemistry, Islamabad, Pakistan)
Hussain Shabbir (GC University, Department of Chemistry, Faisalabad, Pakistan)
Ali Kulsoom Ghulam (GC University, Department of Chemistry, Faisalabad, Pakistan)
Shahid Muhammad (University of Agriculture, Department of Chemistry and Biochemistry, Faisalabad, Pakistan)

A series of di and triorganotin(IV) complexes of the general formula, R2(Cl)SnL (R= Me: 1; Bu: 2) and R3SnL (R = Bu: 3; Ph: 4) have been synthesized by refluxing equivalent molar ratios of orgnotin(IV) chlorides (R2SnCl2/R3SnCl) with the 1H-1,2,4-Triazole-3-thiol (LH) in dry methanol. The synthesized complexes (1-4) were further treated with CS2 and R2SnCl2/R3SnCl in 1:1:1 molar ratio to yield the homobimetallic complexes of the types R2(Cl)SnLCS2Sn(Cl)R2 (R = Me: 5; Bu: 6) and R3SnLCS2SnR3 (R = Bu: 7; Ph: 8). The ligand and the complexes have been characterized by elemental microanalysis (CHNS), FT-IR and multinuclear NMR (1H&13C), and electron ionization mass spectrometry. IR data demonstrates that the dithiocarbamate donor site of the ligand acts in a bidentate manner and there isa trigonal bipyramidal geometry around Sn(IV) in solid state. 1H and 13C NMR data supports the tetrahedralgeometry with thiol donor sites of the ligand while tetra and penta coordinated environments around dithiocarboxylate bound tin(IV) in solution state. Mass spectrometric data supported well the structures of the synthesized complexes. The homobimetallic derivatives were found more active than mononuclear organotin(IV) compounds and free ligand against various strains of bacteria and fungus.

Keywords: homobimetallic complex, organotin chloride, NMR, IR, mass spectra, antimicrobial study, 1H-1, 2, 4-triazole-3-thiol, dithiocarboxylate