Decreased miR-7 Expression in the Skin and Sera of Patients with Dermatomyositis

Authors

  • Yuka Oshikawa
  • Masatoshi Jinnin
  • Takamitsu Makino
  • Ikko Kajihara
  • Katsunari Makino
  • Noritoshi Honda
  • Wakana Nakayama
  • Kuniko Inoue
  • Satoshi Fukushima
  • Hironobu Ihn

DOI:

https://doi.org/10.2340/00015555-1459

Keywords:

autoimmune diseases, polymerase chain reaction, polymyositis.

Abstract

Expression of microRNA (miRNA) in the skin in dermatomyositis has not previously been studied in detail. In this study, we performed miRNA array analysis using miRNAs purified from dermatomyositis-involved skin and normal skin, and found that several miRNAs were up- or down-regulated in dermatomyositis skin. Among them, we focused on miR-7, one of the most down-regulated miRNAs in dermatomyositis skin. Total miRNAs were purified from serum, and hsa-miR-7 levels were measured with quantitative real-time PCR using the specific primer. Serum levels of miR-7 were significantly decreased in patients with dermatomyositis compared with normal subjects or patients with other autoimmune diseases. Thus, serum miR-7 levels might be a possible diagnostic marker for dermatomyositis. Clarifying the up- or down-stream events of down-regulated miR-7 in patients with dermatomyositis may lead to further understanding of the disease and a new therapeutic approach.

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Published

2012-09-19

How to Cite

Oshikawa, Y., Jinnin, M., Makino, T., Kajihara, I., Makino, K., Honda, N., Nakayama, W., Inoue, K., Fukushima, S., & Ihn, H. (2012). Decreased miR-7 Expression in the Skin and Sera of Patients with Dermatomyositis. Acta Dermato-Venereologica, 93(3), 273–276. https://doi.org/10.2340/00015555-1459

Issue

Vol. 93 No. 3 (2013)

Section

Articles

License

Copyright (c) 2012 Yuka Oshikawa, Masatoshi Jinnin, Takamitsu Makino, Ikko Kajihara, Katsunari Makino, Noritoshi Honda, Wakana Nakayama, Kuniko Inoue, Satoshi Fukushima, Hironobu Ihn

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.

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