Association between change in physical activity and short-term disability progression in multiple sclerosis.

Abstract

OBJECTIVE: This study examined change in physical activity as a behavioral correlate of short-term disability progression in persons with multiple sclerosis over a 6-month period. DESIGN: Panel design. SUBJECTS: The sample included 292 persons with multiple sclerosis. METHODS: Participants wore an accelerometer for 7 days as a measure of physical activity and then provided demographics and clinical information and completed the Patient Determined Disease Steps scale as a measure of disability. After a 6-month period, participants provided information about the occurrence of a relapse in the previous 6 months and again wore an accelerometer for 7 days and completed the Patient Determined Disease Steps scale. RESULTS: Panel analysis indicated associations between baseline physical activity and disability (path coefficient= -0.41, p<0.001) and 6-month change in physical activity and disability progression (path coefficient= -0.09, p=0.025). CONCLUSION: Such findings provide preliminary support for a reduction in physical activity as a behavioral correlate, but not necessarily cause, of short-term disability progression in persons with multiple sclerosis.