Triamcinolone acetonide vs procaine hydrochloride injection in the management of carpal tunnel syndrome: Randomized placebo-controlled study

Abstract

Objective: The aim of this trial was to compare the efficacy of triamcinolone acetonide and procaine HCl with that of placebo in the treatment of carpal tunnel syndrome. Design: This prospective, randomized placebo-controlled trial included 57 patients (90 median nerves). Ninety median nerves were randomly assigned to 1 of 3 groups: group 1 was injected with 1 ml 0. 09% saline, group 2 was injected with 40 mg triamcinolone acetonide, and group 3 was injected with 4 ml 1% procaine HCl. Clinical and electrophysiological evaluations were performed at study onset, and at 2 and 6 months post-treatment. Results: At study onset no significant differences were observed between groups with respect to clinical and electrophysiological parameters. Clinical and electrophysiological evaluations was improved significantly in groups 2 and 3 at post-treatment (p < 0. 05). No significant changes were observed in group 1 (p > 0. 05). Moreover, groups 2 and 3 had better scores than group 1 at 2 and 6 months post-treatment(p < 0. 05). There was no difference between groups 2 and 3 in terms of change scores of any terms at post-treatment (p > 0. 05). Conclusion: Triamcinolone acetonide and procaine HCl injections are effective regarding short- and long-term outcomes compared with placebo injections, and procaine HCl injection was as effective as steroid injection.