Expression of Cornified Envelope Proteins in Skin and Its Relationship with Atopic Dermatitis Phenotype

Authors

  • Magdalena Trzeciak
  • Monika Sakowicz-Burkiewicz
  • Martyna Wesserling
  • Daria Dobaczewska
  • Jolanta Glen
  • Roman Nowicki
  • Tadeusz Pawelczyk

DOI:

https://doi.org/10.2340/00015555-2482

Keywords:

atopic dermatitis, gene expression, cornified envelope proteins, SPRR3

Abstract

Changes in the expression of cornified envelope (CE) proteins are thought to affect the development and course of atopic dermatitis (AD). The aim of this study was to examine the expression level of CE proteins in order to identify new molecular markers of the AD phenotype. Expression levels of CE proteins were evaluated in the skin of patients with AD (38 biopsies) and healthy subjects (26 biopsies). Levels of FLG, FLG2 and SPRR3 mRNAs and proteins were reduced in AD skin. Levels of LELP-1 and SPRR1A transcripts and proteins were significantly increased in AD skin. SPRR3v2 mRNA level in non-lesional AD skin correlated with severity of AD, and SPRR3 protein level in non-lesional AD skin correlated inversely with pruritus. FLG protein level in AD skin correlated inversely with severity of AD. These results point to SPRR3 as an important factor in AD and itch

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Published

2016-07-04

How to Cite

Trzeciak, M., Sakowicz-Burkiewicz, M., Wesserling, M., Dobaczewska, D., Glen, J., Nowicki, R., & Pawelczyk, T. (2016). Expression of Cornified Envelope Proteins in Skin and Its Relationship with Atopic Dermatitis Phenotype. Acta Dermato-Venereologica, 97(1), 36–41. https://doi.org/10.2340/00015555-2482

Issue

Vol. 97 No. 1 (2017)

Section

Articles

License

Copyright (c) 2016 Magdalena Trzeciak, Monika Sakowicz-Burkiewicz, Martyna Wesserling, Daria Dobaczewska, Glen, Jolanta, Roman Nowicki, Tadeusz Pawelczyk

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

All digitalized ActaDV contents is available freely online. The Society for Publication of Acta Dermato-Venereologica owns the copyright for all material published until volume 88 (2008) and as from volume 89 (2009) the journal has been published fully Open Access, meaning the authors retain copyright to their work.

Unless otherwise specified, all Open Access articles are published under CC-BY-NC licences, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for non-commercial purposes, provided proper attribution to the original work.

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