European Oral Research

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Research Article


DOI :10.26650/eor.2018.525   IUP :10.26650/eor.2018.525    Full Text (PDF)

Clinical evaluation of dental enamel defects and oral findings in coeliac children

Damla Akşit Bıçak, Nafiye Urgancı, Serap Akyüz, Merve Usta, Nuray Uslu kızılkan, Burçin Alev Tüzüner, Ayşen Yarat

Purpose
To examine dental hard and soft tissue changes of coeliac children in order to increase the awareness of the pediatric dentists in prediagnosis of especially undiagnosed coeliac disease.

Materials and methods
Sixty children, 28 (46.7%) boys and 32 (53.3%) girls whose ages were between 6 to 16 years were included in the present study. Thirty children who had undergone endoscopy and diagnosed with the coeliac disease in the Şişli Hamidiye Etfal Hospital, İstanbul, Turkey, formed the study group. Also, thirty children clinically suspected of having the coeliac disease with the same gastrointestinal complaints had undergone endoscopy and proven not coeliac were chosen as the control group. Oral examination involved assessment of dentition and specific and unspecific dental enamel defects. Also, soft tissue lesions, clinical delay of the dental eruption, salivary flow rate, pH, and buffering capacity were examined.

Results
Twenty coeliac patients had enamel defects, however none in the control subjects. In the coeliac group, all enamel defects were diagnosed in permanent teeth and as specific in all children. Grade I dental enamel defects found mainly in the incisors. The clinical delayed eruption was observed in 10 (33.3%) of 30 coeliac children and none of the children in the control group. While the level of DMFT/S numbers and stimulated salivary flow rate were found significantly lower in the coeliac group, pH was found significantly higher.

Conclusion
Oral cavity may be involved in coeliac disease and pediatric dentists can play an important role in the early diagnosis of the coeliac disease.

Keywords: Caries, coeliac disease, dental enamel defects, dental eruption, recurrent aphthous stomatitis

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References

  • 1. Küçükazman M, Ata N, Dal K, Nazlıgül Y. Çölyak hastalığı. Dirim Tıp Derg 2008; 83: 55-92. google scholar
  • 2. Husby S, Koletzko S, Korponay-Szabó IR, Mearin ML, Phillips A, Shamir R, Troncone R, Giersiepen K, Branski D, Catassi C, Lelgeman M, Mäki M, Ribes-Koninckx C, Ventura A, Zimmer KP; ESPGHAN Working Group on Coeliac Disease Diagnosis; ESPGHAN Gastroenterology Committee; European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr 2012; 54: 136-60. google scholar
  • 3. Cataldo F, Montalto G. Celiac disease in the developing countries. A new and challenging public health problem. World J Gastroenterol 2007; 13: 2153-9. google scholar
  • 4. Pastore L, Carroccio A, Compilato D, Panzarella V, Serpico R, Lo Muzio L. Oral manifestations of coeliac disease. J Clin Gastroenterol 2008; 42: 224-32. google scholar
  • 5. Campisi G, Di Liberto C, Iacono G, Compilato D, Di Prima L, Calvino F, Di Marco V, Lo Muzio L, Sferrazza C, Scalici C, Craxì A, Carroccio A. Oral pathology in untreated coeliac disease. Aliment Pharmacol Ther 2007; 26: 1529-36. google scholar
  • 6. Procaccini M, Campisi G, Bufo P, Compilato D, Massaccesi C, Catassi C, Lo Muzio L. Lack of association between celiac disease and dental enamel hypoplasia in a case-control study from İtalian central region. Head Face Med 2007; 3: 25. google scholar
  • 7. Aine L, Maki M, Keyriläinen O, and Collin P. Dental enamel defects in Celiac disease. J Oral Path Med 1990; 19: 241-5. google scholar
  • 8. Maki M, Aine L, Lipsanen V, Koskimies S. Dental enamel defects in first-degree relatives of coeliac disease patients. Lancet 199; 337: 763-4. google scholar
  • 9. Maki M, Sulkanen S, Collin P. Antibodies in relation to gluten intake. Digest Dis 1998; 16: 330-2. google scholar
  • 10. Seow W.K. Enamel hypoplasia in the primary dentition: a review. ASDC J Dent Child 1991; 58: 441-52. google scholar
  • 11. Abenavoli L, Proietti I, Leggio L, Ferrulli A, Vonghia L, Capizzi R, Rotoli M, Amerio PL, Gasbarrini G, Addolorato G. Cutaneous manifestations in Celiac disease. World J Gastroenterol 2006; 12: 843-52. google scholar
  • 12. Wierink CD, Van Dierman DE, Aartman IH, Heymans HS. Dental enamel defects in children with coeliac disease. Int J Paediatr Dent 2007; 17: 163-8. google scholar
  • 13. Lähteenoja H, Toivanen A, Viander M, Mäki M, Irjala K, Räihä I, Syrjänen S. Oral mucosal changes in coeliac patients on a gluten-free diet. Eur J Oral Sci 1998; 106: 899-906. google scholar
  • 14. Bramanti E, Cicciu M, Matacena G, Costa S, Magazzu G. Clinical Evaluation of specific oral manifestations in pediatric patients with ascertained versus potential coeliac disease: A cross-sectional study. Gastroenterol Res Pract 2014; 2014: doi: 10.1155/2014/934159. google scholar
  • 15. Revised criteria for diagnosis of coeliac disease. Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition. Arch Dis Child 1990; 65: 909-11. google scholar
  • 16. Costacurta M, Maturo P, Bartolino M, Docimo R. Oral manifestations of coeliac disease. A clinical-statistic srudy. Oral Implantol (Rome) 2010; 1: 12-9. google scholar
  • 17. Avşar A, Kalaycı AG. The presence and distribution of dental enamel defects and caries in children with celiac disease. Turk J Pediatr 2008; 50: 45-50. google scholar
  • 18. Rashid M, Zarkadas M, Anca A, Limeback H. Oral manifestations of celiac disease: A clinical guide for dentists. J Can Assoc 2011; 77: 39-44. google scholar
  • 19. Ortega Páez E, Junco Lafuente P, Baca García P, Maldonado Lozano J, Llodra Calvo JC. Prevalence of dental enamel defects in celiac patients with deciduous dentition: a pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; 106: 74-8. google scholar
  • 20. Aine L. Dental enamel defects and dental maturity in children and adolescents with coeliac disease. Proc Finn Dent Soc 1986; 82: 1-7. google scholar
  • 21. World Health Organization. Oral health surveys: basic methods 4th edn. Geneva: WHO; 1997. google scholar
  • 22. Erriu M, Canargiu F, Orru G, Garau V, Montaldo C. Idiopathic atrophic glossitis as the only clinical sign for celiac disease diagnosis: a case report. J Med Case Rep 2012; 6: 185. google scholar
  • 23. Cigic L, Galic T, Kero D, Simunic M, Mikic IM, Govorko DK, Lukenda DB. The prevalence of celiac disease in patients with geographic tongue. J Oral Pathol Med 2016; 45: 791-6. google scholar
  • 24. Ertekin V, Sümbüllü MA, Tosun MS, Selimoğlu MA, Kara M, Kılıç N. Oral findings in children with celiac disease. Turk J Med Sci 2012; 42: 613-7. google scholar
  • 25. Mina S, Azcurra AI, Riga C, Cornejo LS, Brunotto M. Evaluation of clinical dental variables to build classifiers to predict celiac disease. Med Oral Patol Oral Cir Bucal 2008; 13: 398-402. google scholar
  • 26. Campisi G, Di Liberto C, Carroccio A, Compilato D, Iacono G, Procaccini M, Di Fede G, Lo Muzio L, Craxi A, Catassi C, Scully C. Coeliac disease: Oral ulcer prevalence, assessment of risk and association with gluten-free diet in children. Dig Liver Dis 2008; 40: 104-7. google scholar
  • 27. Koç Öztürk L, A Yarat, Akyuz S, Furuncuoglu H, Ulucan K. Investigation of the N-terminal coding region of MUC7 alterations in dentistry students with and without caries. Balkan J Med Genet 2016; 19: 71-6. google scholar
  • 28. Da Silva PC, de Almeida P del V, Machado MA, de Lima AA, Grégio AM, Trevilatto PC, Azevedo-Alanis LR. Oral manifestations of celiac disease. A case report and review of the literature. Med Oral Patol Oral Cir Bucal 2008; 13: 559-62. google scholar
  • 29. Holmes GKT, Prior P, Lane MR, Pope D, Allan RN. Malignancy in coeliac disease: effect of a gluten free diet. Gut 1989; 30: 333-8. google scholar
  • 30. Aquirre JM, Rotriguez R, Oribe D, Vitoria JC. Dental enamel defects in celiac patients. Oral Surg Oral Med Oral Path Oral Radiol Endod 1997; 84: 646-50. google scholar
  • 31. Acar S, Aykut Yetkiner A, Ersin N, Oncag O, Aydogdu S, Arıkan C. Oral findings and salivary parameters in children with celiac disease: A preliminary study. Med Princ Pract 2012; 21: 129-33. google scholar
  • 32. Farmakis E, Puntis JW, Toumba KJ. Enamel defects in children with coeliac disease. Eur J Paediatr Dent 2005; 6: 129-32. google scholar
  • 33. Priovolou CH, Vanderas AP, Papagiannoulis L. A comperative study on the prevalence of enamel defects and dental caries in children and adolescents with and without coeliac disease. Eur J Paediatr Dent 2004; 5: 102-6. google scholar
  • 34. Cantekin K, Arslan D, Delikan E. Presence and distribution of dental enamel defects, recurrent aphtous lesions and dental caries in children with celiac disease. Pak J Med Sci 2015; 31: 606-9. google scholar
  • 35. Ouda S, Saadah O, El Meligy O, Alaki S. Genetic and dental study of patients with celiac disease. J Clin Pediatric Dent 2010; 35: 217-24. google scholar
  • 36. Shteyer E, Berson T, Lachmanovitz O, Hidas A, Wilschanski M, Menachem M, Shachar E, Shapira J, Steinberg D, Moskovitz M. Oral health status and salivary properties in relation to gluten-free diet in children with celiac disease. J Pediatr Gastroenterol Nutr 2013; 57: 49-52. google scholar
  • 37. Rasmusson CG, Eriksson MA. Celiac diasese and mineralisation disturbances of permanent teeth. Int J Paediatr Dent 2001; 11: 179-83. google scholar
  • 38. Cheng J, Malahias T, Brar P, Minaya MT, Green PH. The association between celiac disease, dental enamel defects, and aphthous ulcers in a United States Cohort. J Clin Gastroenterol 2010; 44: 191-4. google scholar
  • 39. Aine L. Coeliac-type permanent-tooth enamel defects. Ann Med 1996; 28: 9-12. google scholar
  • 40. Sedghizadeh P, Schuler CF, Allen CM, Beck FM, Kalmar JR. Celiac disease and recurrent aphtous stomatitis: A report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002; 94: 474-8. google scholar
  • 41. Yaşar Ş, Yaşar B, Abut E, Aşıran Serdar Z. Clinical importance of celiac disease in patients with recurrent aphthous stomatitis. Turk J Gastroenterol 2012; 23: 14-8. google scholar
  • 42. Collin P, Reunala T, Pukkala E, Laippala P, Keyriläinen O, Pasternack A. Coeliac disease--associated disorders and survival. Gut 1994; 35: 1215-8. google scholar
  • 43. Lenander-Lumikari, Ihalin R, Lähteenoja H. Changes in whole saliva in patients with coeliac disease. Arch Oral Biol 2000; 45: 347-54. google scholar
  • 44. Fasano A, Catassi C. Current approaches to diagnosis and treatment of celiac disease: an evolving spectrum. Gastroenterology 2001; 120: 636-51. google scholar
  • 45. Mariani P, Mazzilli MC, Margutti G, Lionetti P, Triglione P, Petronzelli F, Ferrante E, Bonamico M. Coeliac disease, enamel defects and HLA typing. Acta Paediatr 1994; 83: 1272-5. google scholar

Citations

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APA

Akşit Bıçak, D., Urgancı, N., Akyüz, S., Usta, M., Uslu kızılkan, N., Tüzüner, B.A., & Yarat, A. (2018). Clinical evaluation of dental enamel defects and oral findings in coeliac children. European Oral Research, 52(3), 150-156. https://doi.org/10.26650/eor.2018.525


AMA

Akşit Bıçak D, Urgancı N, Akyüz S, Usta M, Uslu kızılkan N, Tüzüner B A, Yarat A. Clinical evaluation of dental enamel defects and oral findings in coeliac children. European Oral Research. 2018;52(3):150-156. https://doi.org/10.26650/eor.2018.525


ABNT

Akşit Bıçak, D.; Urgancı, N.; Akyüz, S.; Usta, M.; Uslu kızılkan, N.; Tüzüner, B.A.; Yarat, A. Clinical evaluation of dental enamel defects and oral findings in coeliac children. European Oral Research, [Publisher Location], v. 52, n. 3, p. 150-156, 2018.


Chicago: Author-Date Style

Akşit Bıçak, Damla, and Nafiye Urgancı and Serap Akyüz and Merve Usta and Nuray Uslu kızılkan and Burçin Alev Tüzüner and Ayşen Yarat. 2018. “Clinical evaluation of dental enamel defects and oral findings in coeliac children.” European Oral Research 52, no. 3: 150-156. https://doi.org/10.26650/eor.2018.525


Chicago: Humanities Style

Akşit Bıçak, Damla, and Nafiye Urgancı and Serap Akyüz and Merve Usta and Nuray Uslu kızılkan and Burçin Alev Tüzüner and Ayşen Yarat. “Clinical evaluation of dental enamel defects and oral findings in coeliac children.” European Oral Research 52, no. 3 (May. 2024): 150-156. https://doi.org/10.26650/eor.2018.525


Harvard: Australian Style

Akşit Bıçak, D & Urgancı, N & Akyüz, S & Usta, M & Uslu kızılkan, N & Tüzüner, BA & Yarat, A 2018, 'Clinical evaluation of dental enamel defects and oral findings in coeliac children', European Oral Research, vol. 52, no. 3, pp. 150-156, viewed 16 May. 2024, https://doi.org/10.26650/eor.2018.525


Harvard: Author-Date Style

Akşit Bıçak, D. and Urgancı, N. and Akyüz, S. and Usta, M. and Uslu kızılkan, N. and Tüzüner, B.A. and Yarat, A. (2018) ‘Clinical evaluation of dental enamel defects and oral findings in coeliac children’, European Oral Research, 52(3), pp. 150-156. https://doi.org/10.26650/eor.2018.525 (16 May. 2024).


MLA

Akşit Bıçak, Damla, and Nafiye Urgancı and Serap Akyüz and Merve Usta and Nuray Uslu kızılkan and Burçin Alev Tüzüner and Ayşen Yarat. “Clinical evaluation of dental enamel defects and oral findings in coeliac children.” European Oral Research, vol. 52, no. 3, 2018, pp. 150-156. [Database Container], https://doi.org/10.26650/eor.2018.525


Vancouver

Akşit Bıçak D, Urgancı N, Akyüz S, Usta M, Uslu kızılkan N, Tüzüner BA, Yarat A. Clinical evaluation of dental enamel defects and oral findings in coeliac children. European Oral Research [Internet]. 16 May. 2024 [cited 16 May. 2024];52(3):150-156. Available from: https://doi.org/10.26650/eor.2018.525 doi: 10.26650/eor.2018.525


ISNAD

Akşit Bıçak, Damla - Urgancı, Nafiye - Akyüz, Serap - Usta, Merve - Uslu kızılkan, Nuray - Tüzüner, BurçinAlev - Yarat, Ayşen. “Clinical evaluation of dental enamel defects and oral findings in coeliac children”. European Oral Research 52/3 (May. 2024): 150-156. https://doi.org/10.26650/eor.2018.525



TIMELINE


Last Revision22.11.2017
Accepted11.01.2018
Published Online01.09.2018

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