Molecular hydrogen in the treatment of acute and chronic neurological conditions: mechanisms of protection and routes of administration

Kenji Dohi; Kazue Satoh; Kazuyuki Miyamoto; Shusuke Momma; Kenichiro Fukuda; Ryo Higuchi; Hirokazu Ohtaki; Williams A Banks

doi:10.3164/jcbn.16-87

Review

Molecular hydrogen in the treatment of acute and chronic neurological conditions: mechanisms of protection and routes of administration

Kenji Dohi, Kazue Satoh, Kazuyuki Miyamoto, Shusuke Momma, Kenichiro Fukuda, Ryo Higuchi, Hirokazu Ohtaki, Williams A Banks

Author information

Kenji Dohi
Department of Emergency, Disaster and Critical Care Medicine, School of Medicine, Showa University
Department of Emergency Medicine, The Jikei University School of Medicine
Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington
Kazue Satoh
Department of Anatomy, School of Medicine, Showa University
Kazuyuki Miyamoto
Department of Emergency, Disaster and Critical Care Medicine, School of Medicine, Showa University
Shusuke Momma
Department of Emergency, Disaster and Critical Care Medicine, School of Medicine, Showa University
Kenichiro Fukuda
Department of Emergency, Disaster and Critical Care Medicine, School of Medicine, Showa University
Ryo Higuchi
Department of Emergency, Disaster and Critical Care Medicine, School of Medicine, Showa University
Hirokazu Ohtaki
Department of Anatomy, School of Medicine, Showa University
Williams A Banks
Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington

Keywords: hydrogen, central nervous system, neurodegenerative disease, oxidative stress, neuroinflammation

JOURNAL OPEN ACCESS

2017 Volume 61 Issue 1 Pages 1-5

DOI https://doi.org/10.3164/jcbn.16-87

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Abstract

Oxidative stress caused by reactive oxygen species is considered a major mediator of tissue and cell injuries in various neuronal conditions, including neurological emergencies and neurodegenerative diseases. Molecular hydrogen is well characterized as a scavenger of hydroxyl radicals and peroxynitrite. Recently, the neuroprotective effects of treatment with molecular hydrogen have been reported in both basic and clinical settings. Here, we review the effects of hydrogen therapy in acute neuronal conditions and neurodegenerative diseases. Hydrogen therapy administered in drinking water may be useful for the prevention of neurodegenerative diseases and for reducing the symptoms of acute neuronal conditions.

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