Caffeine Activates Brown Adipose Tissue Thermogenesis and Metabolic Rate in Mice

Keiji YOSHIOKA; Toshihide YOSHIDA; Kohkichi KAMANARU; Noriya HIRAOKA; Motoharu KONDO

doi:10.3177/jnsv.36.173

Keiji YOSHIOKA, Toshihide YOSHIDA, Kohkichi KAMANARU, Noriya HIRAOKA, Motoharu KONDO

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Keywords: caffeine, brown adipose tissue (BAT), GDP binding, oxygen consumption, resting metabolic rate (RMR), BAT temperature

JOURNAL FREE ACCESS

1990 Volume 36 Issue 2 Pages 173-178

DOI https://doi.org/10.3177/jnsv.36.173

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Abstract

To clarify the effect of caffeine on brown adipose tissue (BAT) thermogenesis, we measured guanosine-5'-diphosphate (GDP) binding, a thermogenic indicator of BAT, and oxygen consumption in BAT mitochondria as well as BAT temperature and resting metabolic rate (RMR) in mice. Intraperitoneal injection of caffeine (60mg/kg) sig-nificantly elevated BAT temperature with less effect on core temperature, and increased significantly GDP binding and oxygen consumption in BAT mitochondria, and RMR. These results suggest that caffeine activates BAT thermogenesis, which may contribute to the increase of RMR.

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