J Appl Biomed 5:125-130, 2007 | DOI: 10.32725/jab.2007.017

Phenylhydrazine haematotoxicity

Josef Berger*
Faculty of Health and Social Studies, University of South Bohemia, Èeské Budìjovice, Czech Republic

Phenylhydrazine (PHZ) and its derivatives were first given a medical application at the end of the 19th century but with very little benefit. However, this compound seems to be very useful in models studying mechanisms of haemolytic anaemia. Phenylhydrazine induces a reactive oxygen species formation, peroxidation of lipids and oxidative degradation of spectrin in the membrane skeleton. PHZ-induced haemolytic injury seems to be derived from oxidative alternations to red blood cell proteins. This compound can modulate immune reactions.

Keywords: reactive oxygen species; membrane proteins; spectrin; haemolytic anaemia; mutagenity

Received: May 16, 2007; Revised: June 29, 2007; Published: July 31, 2007  Show citation

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Berger J. Phenylhydrazine haematotoxicity. J Appl Biomed. 2007;5(3):125-130. doi: 10.32725/jab.2007.017.
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