Evaluation of hypolipidemic, antidiabetic and anti-oxidant activity of Eulophia herbacea tubers

Authors

  • Anil U. Tatiya R. C. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur, Dist-Dhule, Maharashtra
  • Pallavi M. Puranik R. C. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur, Dist-Dhule, Maharashtra
  • Sanjay J. Surana R. C. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur, Dist-Dhule, Maharashtra
  • Yogesh S. Patil R. C. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur, Dist-Dhule, Maharashtra
  • Rakesh E. Mutha R. C. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur, Dist-Dhule, Maharashtra

DOI:

https://doi.org/10.3329/bjp.v8i3.14880

Keywords:

Eulophia herbacea, Orchidaceae, Triton WR-1339, Alloxan, Super oxide radical, histopathology,

Abstract

The tuber of Eulophia herbacea is widely used in the treatment of obesity in traditional medicine. Methanolic extract, aqueous extract and isolated glucomannan were tested for triton WR-1339 induced hyperlipidemia and alloxan-induced diabetes in rats. Blood samples were collected and analysed for lipid profile and blood glucose. Glucomannan was isolated and characterised. Anti-oxidant activity of test sample was determined by superoxide radical and lipid peroxidation assay and compared it with standards ascorbic acid. The findings showed that folk medicinal claim of E. herbacea tubers possess hypolipidemic, hypoglycemic and anti-oxidant effects.

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References

Adeneye AA, Adeyemi OO, Agjabe EO. Anti-obesity and antihyperlipidaemic effect of Hunteria umbellata seed extract in experimental hyperlipidaemia. J Ethnopharmacol. 2010; 130: 307-14.

Anonymous. The Wealth of India, Raw Materials. A dictionary of Indian raw materials and industrial products. Council of Scientific and Industrial Research, New Delhi, 3(D-E), 2003, pp 221-22.

Assmann G, Schriewer H, Schmitz G, Hagele EO. Quantification of high density lipoprotein cholesterol by precipitation with phosphortungstic acid/MgCl2. Clin Chem. 1983; 29: 2026-30.

Bafna AR, Mishra SH. In vitro antioxidant activity of methanol extract of rhizomes of Curculigo orchioides Gaertn. ARS Pharmaceutica, 2005; 46: 125-38.

Banerjee A, Vaghasiya R, Shrivastava N, Padh H, Nivsarkar M. Antihyperlipidaemic effect of Carica papaya L. in Sprague Dawley rats. Nigerian J Nat Prod Med. 2006; 10: 69-72.

Bhattacharjee SK. Handbook of medicinal plants. 3rd ed. Pointer publishers, Jaipur, 2001, pp 150-51.

Buchala AJ, Franz G, Meier H. A glucomannan from the tubers of Orchis morio. Phytochem. 1974; 13: 163-66.

Cao G, Sofic E, Prior RL. Antioxidant and prooxidant behaviour of flavonoids: structure-activity relationships. Free Radical Biol Med. 1997; 22: 749-56.

Demacker PN, Hijmans AG, Vos-Jansses HE, Van't Laar A, Jansen AP. A study of the use of polyethylene glycol in estimating cholesterol in high density lipoproteins. Clin Chem. 1980; 26: 1775-79.

Dogan M, Kayacier A. Rheological properties of reconstituted hot salep beverage. Int J Food Prop. 2004; 7: 683-91.

Friedwald J, Levy YR, Friedrickson SD. Estimation of concentration of low density lipoprotein cholesterol in plasma without use of preparative ultracentrifuge. Clin Chem. 1972; 18: 499-502.

Foster JB, Dunn RT. Stable reagents for determination of serum triglyceride by colorimetric condensation method. Clin Chim Acta. 1973; 19: 338-40.

Grover JK, Yadav S, Vats V. Hypoglycemic and antihyperglycemic effect of Brassica juncea diet and their effect on hepatic glycogen content and the key enzymes of carbohydrate metabolism. Mol Cell Biochem. 2002; 241: 95-101.

Jain P, Agrawal R. Antioxidant and free radical scavenging properties of developed mono- and polyherbal formulations. Asian J Exp Sci. 2008; 22: 213-20.

Jaya C, Anuradha VA. Cissus quadrangularis stem alleviates insulin resistance, oxidative injury and fatty liver disease in rats fed high fat plus fructose diet. Food Chem Toxicol. 2010; 48: 2021-29.

Kaur C, Kapoor HC. Antioxidant activity and total phenolic content of some asian vegetables. Int J Food Sci Tech. 2002; 37: 153-61

Khare CP. Indian Medicinal Plants: An Illustrated Dictionary. Spring Science Business Media, LLC, New Delhi, India, 2007, pp 248-49.

Liu C, Ching Y, Yih M, Chin Y. Ultrasound assisted extraction methodology as a tool to improve the antioxidant properties of herbal drug via O-chia-hu-tang. J Ethnopharmacol. 2005; 99: 293-300.

Lu H, Chen J, Li W, Ren B, Wu J, Kang H, Zhang H, Adams A, Kimpe N. Hypoglycemic and hypolipidemic effects of the total triterpene acid fraction from Folium eriobotryae. J Ethnopharmacol. 2009; 122: 486-91.

Maridass M, Raju G, Ghanthikumar S. Tissue-regenerative responses on Eulophia Epidendraea (Retz.) fischer in Wistar rats. Pharmacologyonline 2008; 3: 631-36.

Maruthappan V, Sakhti Shree K. Hypolipidemic activity of haritaki (Terminalia chebula) in atherogenic diet induced hyperlipidemic rats. J Adv Pharm Technol Res. 2010; 1: 229-35.

Melinda C, Baldwin TC, Hocking TJ. Traditional uses and potential health benefits of Amorphophallus konjac K. Koch ex N.E. Br J Ethnopharmacol. 2010; 128: 268-78.

Merina A, Sivanesan D, Begum V, Sulochana N. Antioxidant and hypolipidemic effect of Plumeria rubra l. in alloxan induced hyperglycemic rats. e-J Chem. 2010; 7: 1-5.

Minhajuddin M, Beg Z, Iqbal J. Hypolipidemic and antioxidant properties of tocotrienol rich fraction isolated from rice bran oil in experimentally induced hyperlipidemic rats. Food Chem Toxicol. 2005; 43: 747-53.

Mukherjee PK, Maiti K, Mukherjee K, Houghton PJ. Leads from Indian medicinal plants with hypoglycemic potentials. J Ethnopharmacol. 2006; 106: 128.

Nadkarni AK. Indian Materia Medica. Volume I. 3rd ed. Bombay Popular Prakashan, Bombay, 1991, pp 414-18.

Patil U, Saraf S, Dixit V. Hypolipidemic activity of seeds of Cassia tora Linn. J Ethnopharmacol. 2004; 90: 249-52.

Tamer C, Karaman B, Copur O. A traditional beverage: Salep. Food Rev Int. 2006; 22: 43-50.

Tekinsen K, Guner A. Chemical composition & physicochemical properties of tuber salep produced from some orchidaceae species. Food Chem. 2010; 121: 468-71.

Tripathi YB, Sing AV. Effect of Semencarpus anacardium nuts on lipid peroxidation. Indian J Exp Biol. 2001; 39: 798.

Umbare R, Mate G, Jawalkar D, Patil S, Dongare S. Quality evaluation of Phyllanthus amarus (Schumach) leaves extract for its hypolipidemic activity. Biol Med. 2009; 1: 28-33.

Additional Files

Published

2013-06-11

How to Cite

Tatiya, A. U., P. M. Puranik, S. J. Surana, Y. S. Patil, and R. E. Mutha. “Evaluation of Hypolipidemic, Antidiabetic and Anti-Oxidant Activity of Eulophia Herbacea Tubers”. Bangladesh Journal of Pharmacology, vol. 8, no. 3, June 2013, pp. 269-75, doi:10.3329/bjp.v8i3.14880.

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Research Articles