Long Non-Coding RNAs at the Chromosomal Risk Loci Identified by Prostate and Breast Cancer GWAS
Abstract
:1. Introduction
2. Prostate Cancer Risk-Associated SNPs Modulating lncRNAs
3. Breast Cancer Risk-Associated SNPs Modulating lncRNAs
lncRNA | SNP | Function of lncRNA | References | |
---|---|---|---|---|
Prostate cancer | PCAT1 | rs7463708 | Promote prostate cancer growth by interacting with AR and LSD1 upon prolonged androgen treatment, Promote prostate cancer cell proliferation through c-Myc upregulation | [30,50,51] |
rs10086908 | ||||
rs1902432 | ||||
PRNCR1/PCAT8 | rs16901946 | Enhance ligand-dependent and -independent AR-mediated transcriptional activity | [53,54,55] | |
rs13252298 | ||||
rs1016343 | ||||
rs1456315 | ||||
CDKN2B-AS1/ANRIL | rs4977574 | Increase prostate cancer cell proliferation and migration by modulating the let-7a/TGFB1/Smad signaling pathway | [60,61,62] | |
rs1333048 | ||||
rs10757278 | ||||
PCAT19 | rs11672691 | PCAT19-long isoform promotes prostate cancer progression by upregulating a subset of cell-cycle genes via interaction with HNRNPAB | [63,64,65] | |
rs887391 | ||||
PVT1 | rs378854 | PVT1 knockdown inhibits prostate cancer growth in vitro and in vivo and increased cell apoptosis | [66,68] | |
Breast cancer | RP11–218M22.1 | rs12422552 | Knockdown reduced breast cancer cell proliferation and colony formation | [73] |
RP11–467J12.4/ PR-lncRNA1 | rs3112612 | Knockdown reduced breast cancer cell proliferation and colony formation | [73] | |
CTD-3032H12.1 | rs28539243 | Knockdown reduced breast cancer cell proliferation and colony formation, predicted to interact with lncRNA RP11-20F24.2 and mRNA of ANKRD30A | [73,74] | |
GABPB1-AS1 | rs71124350 | Predicted association with two miRNA networks, which are differentially regulated in breast cancer | [6,78] | |
rs28489579 | ||||
HOTAIR | rs1899663 | Overexpression of HOTAIR correlates with metastasis of breast cancer, increase breast cancer cell invasiveness via reprogramming PRC2 binding | [81,82,83,84,85,86,87] | |
rs7958904 | ||||
rs4759314 | ||||
rs920778 | ||||
rs12826786 | ||||
H19 | rs3741219 | Overexpression of H19 promoted breast cancer cell proliferation and migration and knockdown reduced estrogen-induced breast cancer cell growth | [89,90,91] | |
rs217727 |
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Sung, H.; Ferlay, J.; Siegel, R.L.; Laversanne, M.; Soerjomataram, I.; Jemal, A.; Bray, F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 2021, 71, 209–249. [Google Scholar] [CrossRef]
- Kar, S.P.; Beesley, J.; Amin Al Olama, A.; Michailidou, K.; Tyrer, J.; Kote-Jarai, Z.; Lawrenson, K.; Lindstrom, S.; Ramus, S.J.; Thompson, D.J.; et al. Genome-wide meta-analyses of breast, ovarian, and prostate cancer association studies identify multiple new susceptibility loci shared by at least two cancer types. Cancer Discov. 2016, 6, 1052–1067. [Google Scholar] [CrossRef] [Green Version]
- Burgos-Aceves, M.A.; Smith, Y. microRNAs Downregulation in Cancer is Associated with Guanine Enrichment in the Terminal Loop Sequences of their Precursors. MicroRNA 2018, 7, 20–27. [Google Scholar] [CrossRef]
- Edwards, S.L.; Beesley, J.; French, J.D.; Dunning, A.M. Beyond GWASs: Illuminating the Dark Road from Association to Function. Am. J. Hum. Genet. 2013, 93, 779–797. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Srinivasan, S.; Clements, J.A.; Batra, J. Single nucleotide polymorphisms in clinics: Fantasy or reality for cancer? Crit. Rev. Clin. Lab. Sci. 2016, 53, 29–39. [Google Scholar] [CrossRef]
- Suvanto, M.; Beesley, J.; Blomqvist, C.; Chenevix-Trench, G.; Khan, S.; Nevanlinna, H. SNPs in lncRNA Regions and Breast Cancer Risk. Front. Genet. 2020, 11, 550. [Google Scholar] [CrossRef] [PubMed]
- Milne, R.L.; Kuchenbaecker, K.B.; Michailidou, K.; Beesley, J.; Kar, S.; Lindström, S.; Hui, S.; Lemaçon, A.; Soucy, P.; Lemaçon, A.; et al. Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Nat. Genet. 2017, 49, 1767–1778. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- The FANTOM Consortium; Carninci, P.; Kasukawa, T.; Katayama, S.; Gough, J.; Frith, M.C.; Maeda, N.; Oyama, R.; Ravasi, T.; Lenhard, B.; et al. The Transcriptional Landscape of the Mammalian Genome. Science 2005, 309, 1559–1563. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Alexander, R.P.; Fang, G.; Rozowsky, J.; Snyder, M.; Gerstein, M.B. Annotating non-coding regions of the genome. Nat. Rev. Genet. 2010, 11, 559–571. [Google Scholar] [CrossRef]
- Li, J.; Xuan, Z.; Liu, C. Long Non-Coding RNAs and Complex Human Diseases. Int. J. Mol. Sci. 2013, 14, 18790–18808. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Sparber, P.; Filatova, A.; Khantemirova, M.; Skoblov, M. The role of long non-coding RNAs in the pathogenesis of hereditary diseases. BMC Med. Genom. 2019, 12, 63–78. [Google Scholar] [CrossRef] [Green Version]
- DiStefano, J.K. The Emerging Role of Long Noncoding RNAs in Human Disease. Methods Mol. Biol. 2018, 1706, 91–110. [Google Scholar] [CrossRef] [PubMed]
- Esteller, M. Non-coding RNAs in human disease. Nat. Rev. Genet. 2011, 12, 861–874. [Google Scholar] [CrossRef] [PubMed]
- Singh, D.; Khan, M.A.; Siddique, H.R. Emerging role of long non-coding RNAs in cancer chemoresistance: Unravelling the multifaceted role and prospective therapeutic targeting. Mol. Biol. Rep. 2020, 47, 5569–5585. [Google Scholar] [CrossRef]
- Arun, G.; Diermeier, S.D.; Spector, D.L. Therapeutic Targeting of Long Non-Coding RNAs in Cancer. Trends Mol. Med. 2018, 24, 257–277. [Google Scholar] [CrossRef]
- Cao, J. The functional role of long non-coding RNAs and epigenetics. Biol. Proced. Online 2014, 16, 11. [Google Scholar] [CrossRef] [Green Version]
- Cohen, A.; Burgos-Aceves, M.A.; Smith, Y. Estrogen repression of microRNA as a potential cause of cancer. Biomed. Pharmacother. 2016, 78, 234–238. [Google Scholar] [CrossRef] [PubMed]
- Clark, M.B.; Mattick, J.S. Long noncoding RNAs in cell biology. Semin. Cell Dev. Biol. 2011, 22, 366–376. [Google Scholar] [CrossRef]
- Zhang, Y.; Pitchiaya, S.; Cieślik, M.; Niknafs, Y.S.; Tien, J.C.-Y.; Hosono, Y.; Iyer, M.K.; Yazdani, S.; Subramaniam, S.; Shukla, S.; et al. Analysis of the androgen receptor–regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression. Nat. Genet. 2018, 50, 814–824. [Google Scholar] [CrossRef]
- Chen, L.-L. Linking Long Noncoding RNA Localization and Function. Trends Biochem. Sci. 2016, 41, 761–772. [Google Scholar] [CrossRef]
- Rinn, J.L.; Chang, H.Y. Genome Regulation by Long Noncoding RNAs. Annu. Rev. Biochem. 2012, 81, 145–166. [Google Scholar] [CrossRef] [Green Version]
- Nie, L.; Wu, H.-J.; Hsu, J.-M.; Chang, S.-S.; Labaff, A.M.; Li, C.-W.; Wang, Y.; Hsu, J.L.; Hung, M.-C. Long non-coding RNAs: Versatile master regulators of gene expression and crucial players in cancer. Am. J. Transl. Res. 2012, 4, 127–150. [Google Scholar] [PubMed]
- Nelson, B.R.; Makarewich, C.A.; Anderson, D.M.; Winders, B.R.; Troupes, C.D.; Wu, F.; Reese, A.L.; McAnally, J.R.; Chen, X.; Kavalali, E.T.; et al. A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle. Science 2016, 351, 271–275. [Google Scholar] [CrossRef] [Green Version]
- Matsumoto, A.; Pasut, A.; Matsumoto, M.; Yamashita, R.; Fung, J.; Monteleone, E.; Saghatelian, A.; Nakayama, K.I.; Clohessy, J.G.; Pandolfi, P.P. mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide. Nature 2017, 541, 228–232. [Google Scholar] [CrossRef]
- Andrews, S.J.; Rothnagel, J.A. Emerging evidence for functional peptides encoded by short open reading frames. Nat. Rev. Genet. 2014, 15, 193–204. [Google Scholar] [CrossRef] [PubMed]
- Mitobe, Y.; Takayama, K.-I.; Horie-Inoue, K.; Inoue, S. Prostate cancer-associated lncRNAs. Cancer Lett. 2018, 418, 159–166. [Google Scholar] [CrossRef] [PubMed]
- Zhang, T.; Hu, H.; Yan, G.; Wu, T.; Liu, S.; Chen, W.; Ning, Y.; Lu, Z. Long Non-Coding RNA and Breast Cancer. Technol. Cancer Res. Treat. 2019, 18, 1–10. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Lee, B.; Mazar, J.; Aftab, M.N.; Qi, F.; Shelley, J.; Li, J.-L.; Govindarajan, S.; Valerio, F.; Rivera, I.; Thurn, T.; et al. Long Noncoding RNAs as Putative Biomarkers for Prostate Cancer Detection. J. Mol. Diagn. 2014, 16, 615–626. [Google Scholar] [CrossRef] [Green Version]
- Minotti, L.; Agnoletto, C.; Baldassari, F.; Corrà, F.; Volinia, S. SNPs and Somatic Mutation on Long Non-Coding RNA: New Frontier in the Cancer Studies? High-Throughput 2018, 7, 34. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Guo, H.; Ahmed, M.; Zhang, F.; Yao, C.Q.; Li, S.; Liang, Y.; Hua, J.; Soares, F.; Sun, Y.; Langstein, J.; et al. Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer. Nat. Genet. 2016, 48, 1142–1150. [Google Scholar] [CrossRef] [PubMed]
- Adjakly, M.; Ngollo, M.; Dagdemir, A.; Judes, G.; Pajon, A.; Karsli-Ceppioglu, S.; Penault-Llorca, F.; Boiteux, J.-P.; Bignon, Y.-J.; Guy, L.; et al. Prostate cancer: The main risk and protective factors—Epigenetic modifications. Annales d’Endocrinologie 2015, 76, 25–41. [Google Scholar] [CrossRef]
- Brawley, O.W. Prostate cancer epidemiology in the United States. World J. Urol. 2012, 30, 195–200. [Google Scholar] [CrossRef]
- Crawford, E.D. Epidemiology of prostate cancer. Urology 2003, 62, 3–12. [Google Scholar] [CrossRef]
- Mucci, L.A.; Hjelmborg, J.B.; Harris, J.R.; Czene, K.; Havelick, D.J.; Scheike, T.; Graff, R.E.; Holst, K.; Möller, S.; Unger, R.H.; et al. Familial Risk and Heritability of Cancer Among Twins in Nordic Countries. JAMA 2016, 315, 68–76. [Google Scholar] [CrossRef] [Green Version]
- Farashi, S.; Kryza, T.; Clements, J.; Batra, J. Post-GWAS in prostate cancer: From genetic association to biological contribution. Nat. Rev. Cancer 2019, 19, 46–59. [Google Scholar] [CrossRef] [PubMed]
- Conti, D.V.; Darst, B.F.; Moss, L.C.; Saunders, E.J.; Sheng, X.; Chou, A.; Schumacher, F.R.; Al Olama, A.A.; Benlloch, S.; Dadaev, T.; et al. Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. Nat. Genet. 2021, 53, 65–75. [Google Scholar] [CrossRef]
- Jin, G.; Sun, J.; Isaacs, S.D.; Wiley, K.E.; Kim, S.-T.; Chu, L.W.; Zhang, Z.; Zhao, H.; Zheng, S.L.; Isaacs, W.B.; et al. Human polymorphisms at long non-coding RNAs (lncRNAs) and association with prostate cancer risk. Carcinogenesis 2011, 32, 1655–1659. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Hsieh, C.-L.; Oakley-Girvan, I.; Balise, R.R.; Halpern, J.; Gallagher, R.P.; Wu, A.H.; Kolonel, L.N.; O’Brien, L.E.; Lin, I.G.; Berg, D.J.V.D.; et al. A Genome Screen of Families with Multiple Cases of Prostate Cancer: Evidence of Genetic Heterogeneity. Am. J. Hum. Genet. 2001, 69, 148–158. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Cao, D.-L.; Gu, C.-Y.; Zhu, Y.-P.; Dai, B.; Zhang, H.-L.; Shi, G.-H.; Shen, Y.-J.; Ma, C.-G.; Xiao, W.-J.; Qin, X.-J.; et al. Polymorphisms at long non-coding RNAs and prostate cancer risk in an eastern Chinese population. Prostate Cancer Prostatic Dis. 2014, 17, 315–319. [Google Scholar] [CrossRef]
- Chen, Q.-H.; Li, B.; Liu, D.-G.; Zhang, B.; Yang, X.; Tu, Y.-L. LncRNA KCNQ1OT1 sponges miR-15a to promote immune evasion and malignant progression of prostate cancer via up-regulating PD-L1. Cancer Cell Int. 2020, 20, 394. [Google Scholar] [CrossRef]
- Hao, H.; Chen, H.; Xie, L.; Liu, H.; Wang, D. LncRNA KCNQ1OT1 Promotes Proliferation, Invasion and Metastasis of Prostate Cancer by Regulating miR-211-5p/CHI3L1 Pathway. OncoTargets Ther. 2021, 14, 1659–1671. [Google Scholar] [CrossRef]
- Huang, M.-C.; Chou, Y.-H.; Shen, H.-P.; Ng, S.-C.; Lee, Y.; Sun, Y.-H.; Hsu, C.-F.; Yang, S.-F.; Wang, P.-H. The clinicopathological characteristic associations of long non-coding RNA gene H19 polymorphisms with uterine cervical cancer. J. Cancer 2019, 10, 6191–6198. [Google Scholar] [CrossRef] [PubMed]
- Wu, E.-R.; Chou, Y.-E.; Liu, Y.-F.; Hsueh, K.-C.; Lee, H.-L.; Yang, S.-F.; Su, S.-C. Association of lncRNA H19 Gene Polymorphisms with the Occurrence of Hepatocellular Carcinoma. Genes 2019, 10, 506. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Yang, P.-J.; Hsieh, M.-J.; Hung, T.-W.; Wang, S.-S.; Chen, S.-C.; Lee, M.-C.; Yang, S.-F.; Chou, Y.-E. Effects of Long Noncoding RNA H19 Polymorphisms on Urothelial Cell Carcinoma Development. Int. J. Environ. Res. Public Health 2019, 16, 1322. [Google Scholar] [CrossRef] [Green Version]
- Hu, J.-C.; Lin, C.-Y.; Wang, S.-S.; Chiu, K.-Y.; Li, J.-R.; Chen, C.-S.; Hung, S.-C.; Yang, C.-K.; Ou, Y.-C.; Cheng, C.-L.; et al. Impact of H19 Polymorphisms on Prostate Cancer Clinicopathologic Characteristics. Diagnostics 2020, 10, 656. [Google Scholar] [CrossRef]
- Sun, S.-C.; Zhao, H.; Liu, R.; Wang, B.-L.; Liu, Y.-Q.; Zhao, Y.; Shi, Z.-D. Expression of long non-coding RNA H19 in prostate cancer and its effect on the proliferation and glycometabolism of human prostate cancer cells. Zhonghua Nan Ke Xue 2017, 23, 120–124. [Google Scholar] [PubMed]
- Zhu, M.; Chen, Q.; Liu, X.; Sun, Q.; Zhao, X.; Deng, R.; Wang, Y.; Huang, J.; Xu, M.; Yan, J.; et al. Lncrna h19/mir-675 axis represses prostate cancer metastasis by targeting tgfbi. FEBS J. 2014, 281, 3766–3775. [Google Scholar] [CrossRef] [PubMed]
- Roy, H.B.-L.; Vennin, C.; Brocqueville, G.; Spruyt, N.; Adriaenssens, E.; Bourette, R.P. Enrichment of Human Stem-Like Prostate Cells with s-SHIP Promoter Activity Uncovers a Role in Stemness for the Long Noncoding RNA H19. Stem Cells Dev. 2015, 24, 1252–1262. [Google Scholar] [CrossRef] [Green Version]
- Bacci, L.; Aiello, A.; Ripoli, C.; Loria, R.; Pugliese, D.; Pierconti, F.; Rotili, D.; Strigari, L.; Pinto, F.; Bassi, P.F.; et al. H19-dependent transcriptional regulation of beta3 and beta4 integrins upon estrogen and hypoxia favors metastatic potential in prostate cancer. Int. J. Mol. Sci. 2019, 20, 4012. [Google Scholar] [CrossRef] [Green Version]
- Prensner, J.; Iyer, M.K.; Balbin, O.A.; Dhanasekaran, S.M.; Cao, Q.; Brenner, J.C.; Laxman, B.; Asangani, I.; Grasso, C.S.; Kominsky, H.D.; et al. Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression. Nat. Biotechnol. 2011, 29, 742–749. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Prensner, J.; Chen, W.; Han, S.; Iyer, M.K.; Cao, Q.; Kothari, V.; Evans, J.R.; Knudsen, K.; Paulsen, M.T.; Ljungman, M.; et al. The Long Non-Coding RNA PCAT-1 Promotes Prostate Cancer Cell Proliferation through cMyc. Neoplasia 2014, 16, 900–908. [Google Scholar] [CrossRef] [Green Version]
- Yuan, Q.; Chu, H.; Ge, Y.; Ma, G.; Du, M.; Wang, M.; Zhang, Z.; Zhang, W. LncRNA PCAT1 and its genetic variant rs1902432 are associated with prostate cancer risk. J. Cancer 2018, 9, 1414–1420. [Google Scholar] [CrossRef] [Green Version]
- Huang, X.; Zhang, W.; Shao, Z. Association between long non-coding RNA polymorphisms and cancer risk: A meta-analysis. Biosci. Rep. 2018, 38, 38. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Sattarifard, H.; Hashemi, M.; Hassanzarei, S.; Narouie, B.; Bahari, G. Association between genetic polymorphisms of long non-coding RNA PRNCR1 and prostate cancer risk in a sample of the Iranian population. Mol. Clin. Oncol. 2017, 7, 1152–1158. [Google Scholar] [CrossRef] [Green Version]
- Yang, L.; Lin, C.; Jin, C.; Yang, J.C.; Tanasa, B.; Li, W.; Merkurjev, D.; Ohgi, K.A.; Meng, D.; Zhang, J.; et al. Lncrna-dependent mechanisms of androgen-receptor-regulated gene activation programs. Nature 2013, 500, 598–602. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Parolia, A.; Crea, F.; Xue, H.; Wang, Y.; Mo, F.; Ramnarine, V.R.; Liu, H.H.; Lin, D.; Saidy, N.R.N.; Clermont, P.-L.; et al. The long non-coding RNA PCGEM1 is regulated by androgen receptor activity in vivo. Mol. Cancer 2015, 14, 46. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Li, L.; Jia, F.; Bai, P.; Liang, Y.; Sun, R.; Yuan, F.; Zhang, L.; Gao, L. Association between polymorphisms in long non-coding RNA PRNCR1 in 8q24 and risk of gastric cancer. Tumour Biol. 2016, 37, 299–303. [Google Scholar] [CrossRef]
- Li, L.; Sun, R.; Liang, Y.; Pan, X.; Li, Z.; Bai, P.; Zeng, X.; Zhang, D.; Zhang, L.; Gao, L. Association between polymorphisms in long non-coding RNA PRNCR1 in 8q24 and risk of colorectal cancer. J. Exp. Clin. Cancer Res. 2013, 32, 104. [Google Scholar] [CrossRef] [Green Version]
- Li, N.; Cui, Z.; Gao, M.; Li, S.; Song, M.; Wang, Y.; Tong, L.; Bi, Y.; Zhang, Z.; Wang, S.; et al. Genetic Polymorphisms of PRNCR1 and Lung Cancer Risk in Chinese Northeast Population: A Case—Control Study and Meta-Analysis. DNA Cell Biol. 2021, 40, 132–144. [Google Scholar] [CrossRef] [PubMed]
- Al Olama, A.A.; Kote-Jarai, Z.; Berndt, S.I.; Conti, D.V.; Schumacher, F.; Han, Y.; Benlloch, S.; Hazelett, D.; Wang, Z.; Saunders, E.; et al. A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer. Nat. Genet. 2014, 46, 1103–1109. [Google Scholar] [CrossRef] [Green Version]
- Taheri, M.; Pouresmaeili, F.; Omrani, M.D.; Habibi, M.; Sarrafzadeh, S.; Noroozi, R.; Rakhshan, A.; Sayad, A.; Ghafouri-Fard, S. Association of ANRIL gene polymorphisms with prostate cancer and benign prostatic hyperplasia in an Iranian population. Biomark. Med. 2017, 11, 413–422. [Google Scholar] [CrossRef]
- Zhao, B.; Lu, Y.L.; Yang, Y.; Hu, L.B.; Bai, Y.; Li, R.Q.; Zhang, G.Y.; Li, J.; Bi, C.W.; Yang, L.B.; et al. Overexpression of lncrna anril promoted the proliferation and migration of prostate cancer cells via regulating let-7a/tgf-beta1/smad signaling pathway. Cancer Biomark. 2018, 21, 613–620. [Google Scholar] [CrossRef] [Green Version]
- Hua, J.T.; Ahmed, M.; Guo, H.; Zhang, Y.; Chen, S.; Soares, F.; Lu, J.; Zhou, S.; Wang, M.; Li, H.; et al. Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19. Cell 2018, 174, 564–575.e18. [Google Scholar] [CrossRef] [Green Version]
- Al Olama, A.A.; Kote-Jarai, Z.; Schumacher, F.; Wiklund, F.; Berndt, S.I.; Benlloch, S.; Giles, G.; Severi, G.; Neal, D.; Hamdy, F.C.; et al. A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease. Hum. Mol. Genet. 2013, 22, 408–415. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Shui, I.M.; Lindström, S.; Kibel, A.S.; Berndt, S.I.; Campa, D.; Gerke, T.; Penney, K.L.; Albanes, D.; Berg, C.; Bueno-De-Mesquita, H.B.; et al. Prostate Cancer (PCa) Risk Variants and Risk of Fatal PCa in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium. Eur. Urol. 2014, 65, 1069–1075. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Meyer, K.B.; Maia, A.-T.; O’Reilly, M.; Ghoussaini, M.; Prathalingam, R.; Porter-Gill, P.; Ambs, S.; Prokunina-Olsson, L.; Carroll, J.; Ponder, B.A.J. A Functional Variant at a Prostate Cancer Predisposition Locus at 8q24 Is Associated with PVT1 Expression. PLoS Genet. 2011, 7, e1002165. [Google Scholar] [CrossRef] [Green Version]
- Ilboudo, A.; Chouhan, J.; McNeil, B.K.; Osborne, J.R.; Ogunwobi, O.O. PVT1 Exon 9: A Potential Biomarker of Aggressive Prostate Cancer? Int. J. Environ. Res. Public Health 2015, 13, 12. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Yang, J.; Li, C.; Mudd, A.; Gu, X. LncRNA PVT1 predicts prognosis and regulates tumor growth in prostate cancer. Biosci. Biotechnol. Biochem. 2017, 81, 2301–2306. [Google Scholar] [CrossRef] [Green Version]
- Al-Thoubaity, F.K. Molecular classification of breast cancer: A retrospective cohort study. Ann. Med. Surg. 2020, 49, 44–48. [Google Scholar] [CrossRef] [PubMed]
- Harbeck, N.; Penault-Llorca, F.; Cortes, J.; Gnant, M.; Houssami, N.; Poortmans, P.; Ruddy, K.; Tsang, J.; Cardoso, F. Breast cancer. Nat. Rev. Dis. Prim. 2019, 5, 66. [Google Scholar] [CrossRef]
- Michailidou, K.; Collaborators, N.; Lindström, S.; Dennis, J.; Beesley, J.; Hui, S.; Kar, S.; Lemaçon, A.; Soucy, P.; Glubb, D.; et al. Association analysis identifies 65 new breast cancer risk loci. Nature 2017, 551, 92–94. [Google Scholar] [CrossRef] [Green Version]
- Zhang, H.; Ahearn, T.U.; Lecarpentier, J.; Barnes, D.; Beesley, J.; Qi, G.; Jiang, X.; O’Mara, T.A.; Zhao, N.; Bolla, M.K.; et al. Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses. Nat. Genet. 2020, 52, 572–581. [Google Scholar] [CrossRef] [PubMed]
- Wu, L.; Shi, W.; Long, J.; Guo, X.; Michailidou, K.; Beesley, J.; Bolla, M.K.; Shu, X.-O.; Lu, Y.; Cai, Q.; et al. A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer. Nat. Genet. 2018, 50, 968–978. [Google Scholar] [CrossRef] [PubMed]
- Sánchez, Y.; Segura, V.; Marín-Béjar, O.; Athie, A.; Marchese, F.; González, J.; Bujanda, L.; Guo, S.; Matheu, A.; Huarte, M. Genome-wide analysis of the human p53 transcriptional network unveils a lncRNA tumour suppressor signature. Nat. Commun. 2014, 5, 5812. [Google Scholar] [CrossRef] [Green Version]
- Cava, C.; Bertoli, G.; Castiglioni, I. Portrait of Tissue-Specific Coexpression Networks of Noncoding RNAs (miRNA and lncRNA) and mRNAs in Normal Tissues. Comput. Math. Methods Med. 2019, 2019, 9029351. [Google Scholar] [CrossRef]
- Marjaneh, M.M.; Beesley, J.; O’Mara, T.A.; Mukhopadhyay, P.; Koufariotis, L.T.; Kazakoff, S.; Hussein, N.; Fachal, L.; Bartonicek, N.; Hillman, K.M.; et al. Non-coding RNAs underlie genetic predisposition to breast cancer. Genome Biol. 2020, 21, 7. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Betts, J.A.; Marjaneh, M.M.; Al-Ejeh, F.; Lim, Y.C.; Shi, W.; Sivakumaran, H.; Tropee, R.; Patch, A.-M.; Clark, M.; Bartonicek, N.; et al. Long Noncoding RNAs CUPID1 and CUPID2 Mediate Breast Cancer Risk at 11q13 by Modulating the Response to DNA Damage. Am. J. Hum. Genet. 2017, 101, 255–266. [Google Scholar] [CrossRef] [Green Version]
- Xiong, H.; Chen, Z.; Chen, W.; Li, Q.; Lin, B.; Jia, Y. Fkbp-related ncrnamrna axis in breast cancer. Genomics 2020, 112, 4595–4607. [Google Scholar] [CrossRef]
- Qi, W.; Li, Z.; Xia, L.; Dai, J.; Zhang, Q.; Wu, C.; Xu, S. LncRNA GABPB1-AS1 and GABPB1 regulate oxidative stress during erastin-induced ferroptosis in HepG2 hepatocellular carcinoma cells. Sci. Rep. 2019, 9, 16185. [Google Scholar] [CrossRef] [Green Version]
- Gao, S.; Zhang, F.; Sun, H.; Yang, X. Lncrna ga-binding protein transcription factor subunit β-1 antisense RNA 1 inhibits renal carcinoma growth through an mir-1246/phosphoenolpyruvate carboxykinase 1 pathway. OncoTargets Ther. 2020, 13, 6827–6836. [Google Scholar] [CrossRef] [PubMed]
- Lin, Y.; Guo, W.; Li, N.; Fu, F.; Lin, S.; Wang, C. Polymorphisms of long non-coding RNA HOTAIR with breast cancer susceptibility and clinical outcomes for a southeast Chinese Han population. Oncotarget 2017, 9, 3677–3689. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Yan, R.; Cao, J.; Song, C.; Chen, Y.; Wu, Z.; Wang, K.; Dai, L. Polymorphisms in lncRNA HOTAIR and susceptibility to breast cancer in a Chinese population. Cancer Epidemiol. 2015, 39, 978–985. [Google Scholar] [CrossRef] [PubMed]
- Hassanzarei, S.; Hashemi, M.; Sattarifard, H.; Hashemi, S.M.; Bahari, G.; Ghavami, S. Genetic polymorphisms of HOTAIR gene are associated with the risk of breast cancer in a sample of southeast Iranian population. Tumor Biol. 2017, 39, 1010428317727539. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Min, L.; Mu, X.; Tong, A.; Qian, Y.; Ling, C.; Yi, T.; Zhao, X. The association between HOTAIR polymorphisms and cancer susceptibility: An updated systemic review and meta-analysis. OncoTargets Ther. 2018, 11, 791–800. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Mozdarani, H.; Ezzatizadeh, V.; Parvaneh, R.R. The emerging role of the long non-coding RNA HOTAIR in breast cancer development and treatment. J. Transl. Med. 2020, 18, 152. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Cai, B.; Wu, Z.; Liao, K.; Zhang, S. Long noncoding RNA HOTAIR can serve as a common molecular marker for lymph node metastasis: A meta-analysis. Tumor Biol. 2014, 35, 8445–8450. [Google Scholar] [CrossRef]
- Gupta, R.A.; Shah, N.; Wang, K.C.; Kim, J.; Horlings, H.M.; Wong, D.J.; Tsai, M.-C.; Hung, T.; Argani, P.; Rinn, J.L.; et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 2010, 464, 1071–1076. [Google Scholar] [CrossRef] [PubMed]
- Li, M.; Li, X.; Zhuang, Y.; Flemington, E.K.; Lin, Z.; Shan, B. Induction of a novel isoform of the lncrna hotair in claudin-low breast cancer cells attached to extracellular matrix. Mol. Oncol. 2017, 11, 1698–1710. [Google Scholar] [CrossRef]
- Xia, Z.; Yan, R.; Duan, F.; Song, C.; Wang, P.; Wang, K. Genetic Polymorphisms in Long Noncoding RNA H19 Are Associated with Susceptibility to Breast Cancer in Chinese Population. Medicine 2016, 95, e2771. [Google Scholar] [CrossRef] [PubMed]
- Shima, H.; Kida, K.; Adachi, S.; Yamada, A.; Sugae, S.; Narui, K.; Miyagi, Y.; Nishi, M.; Ryo, A.; Murata, S.; et al. Lnc RNA H19 is associated with poor prognosis in breast cancer patients and promotes cancer stemness. Breast Cancer Res. Treat. 2018, 170, 507–516. [Google Scholar] [CrossRef]
- Vennin, C.; Spruyt, N.; Dahmani, F.; Julien, S.; Bertucci, F.; Finetti, P.; Chassat, T.; Bourette, R.; Le Bourhis, X.; Adriaenssens, E. H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b. Oncotarget 2015, 6, 29209–29223. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Sun, H.; Wang, G.; Peng, Y.; Zeng, Y.; Zhu, Q.N.; Li, T.L.; Cai, J.Q.; Zhou, H.H.; Zhu, Y.S. H19 lncrna mediates 17beta-estradiol-induced cell proliferation in mcf-7 breast cancer cells. Oncol. Rep. 2015, 33, 3045–3052. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Mathias, C.; Garcia, L.E.; Teixeira, M.D.; Kohler, A.F.; Marchi, R.D.; Barazetti, J.F.; Gradia, D.F.; de Oliveira, J.C. Polymorphism of lncRNAs in breast cancer: Meta-analysis shows no association with susceptibility. J. Gene Med. 2020, 22, 3271. [Google Scholar] [CrossRef] [PubMed]
- Miao, Y.-R.; Liu, W.; Zhang, Q.; Guo, A.-Y. lncRNASNP2: An updated database of functional SNPs and mutations in human and mouse lncRNAs. Nucleic Acids Res. 2018, 46, D276–D280. [Google Scholar] [CrossRef] [PubMed]
- Gao, Y.; Li, X.; Shang, S.; Guo, S.; Wang, P.; Sun, D.; Gan, J.; Sun, J.; Zhang, Y.; Wang, J.; et al. LincSNP 3.0: An updated database for linking functional variants to human long non-coding RNAs, circular RNAs and their regulatory elements. Nucleic Acids Res. 2021, 49, D1244–D1250. [Google Scholar] [CrossRef]
- Sartori, D.A.; Chan, D.W. Biomarkers in prostate cancer: What’s new? Curr. Opin. Oncol. 2014, 26, 259–264. [Google Scholar] [CrossRef] [PubMed] [Green Version]
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. |
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Janaththani, P.; Srinivasan, S.L.; Batra, J. Long Non-Coding RNAs at the Chromosomal Risk Loci Identified by Prostate and Breast Cancer GWAS. Genes 2021, 12, 2028. https://0-doi-org.brum.beds.ac.uk/10.3390/genes12122028
Janaththani P, Srinivasan SL, Batra J. Long Non-Coding RNAs at the Chromosomal Risk Loci Identified by Prostate and Breast Cancer GWAS. Genes. 2021; 12(12):2028. https://0-doi-org.brum.beds.ac.uk/10.3390/genes12122028
Chicago/Turabian StyleJanaththani, Panchadsaram, Sri Lakshmi Srinivasan, and Jyotsna Batra. 2021. "Long Non-Coding RNAs at the Chromosomal Risk Loci Identified by Prostate and Breast Cancer GWAS" Genes 12, no. 12: 2028. https://0-doi-org.brum.beds.ac.uk/10.3390/genes12122028