Customized Human Milk Fortification Based on Measured Human Milk Composition to Improve the Quality of Growth in Very Preterm Infants: A Mixed-Cohort Study Protocol
Abstract
:1. Introduction
1.1. Biological Advantages of Human Milk
1.2. Methods for Fortification of Human Milk
1.3. Questions to Be Answered
1.4. A Contribution to Answer Some Unsolved Questions
1.5. Objective
1.6. Hypotheses
2. Methods
2.1. Study Design
2.2. Primary Outcome
2.3. Secondary Outcomes
2.4. Setting, Participants, Study Periods, and Variables
2.5. Nutrition Protocol
2.6. Collected Variables
2.6.1. Retrieved Data
2.6.2. Measurements
2.7. Statistical Analysis
2.8. Ethical Issues and Study Registry
3. Discussion
3.1. Strengths
3.2. Limitations
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
ESPGHAN | European Society for Paediatric Gastroenterology Hepatology and Nutrition |
FFM | fat-free mass |
FM | fat mass |
FM% | fat mass percentage |
FMI | fat mass index |
HM | human milk |
NICU | neonatal intensive care unit |
References
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Standard Fortification Arm | Target Fortification Arm |
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Cardoso, M.; Virella, D.; Macedo, I.; Silva, D.; Pereira-da-Silva, L. Customized Human Milk Fortification Based on Measured Human Milk Composition to Improve the Quality of Growth in Very Preterm Infants: A Mixed-Cohort Study Protocol. Int. J. Environ. Res. Public Health 2021, 18, 823. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18020823
Cardoso M, Virella D, Macedo I, Silva D, Pereira-da-Silva L. Customized Human Milk Fortification Based on Measured Human Milk Composition to Improve the Quality of Growth in Very Preterm Infants: A Mixed-Cohort Study Protocol. International Journal of Environmental Research and Public Health. 2021; 18(2):823. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18020823
Chicago/Turabian StyleCardoso, Manuela, Daniel Virella, Israel Macedo, Diana Silva, and Luís Pereira-da-Silva. 2021. "Customized Human Milk Fortification Based on Measured Human Milk Composition to Improve the Quality of Growth in Very Preterm Infants: A Mixed-Cohort Study Protocol" International Journal of Environmental Research and Public Health 18, no. 2: 823. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18020823