Next Article in Journal
Validation of the Disaster Preparedness Evaluation Tool for Nurses—The Korean Version
Previous Article in Journal
Training New Doctors in Mozambique. A Sustainable International Aid Health Program
 
 
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Comparison of the Qualitative and the Quantitative Risk Assessment of Hazardous Substances Requiring Management under the Occupational Safety and Health Act in South Korea

Department of Health and Safety Convergence Science, Graduate School, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Korea
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2021, 18(3), 1354; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18031354
Submission received: 7 January 2021 / Revised: 25 January 2021 / Accepted: 29 January 2021 / Published: 2 February 2021
(This article belongs to the Section Occupational Safety and Health)

Abstract

:
The risk assessment of hazardous substances has become increasingly important for the efficient prevention and management of various diseases or accidents caused by increased amounts of hazardous substances in the workplace. In this study, risk assessment was conducted for 36 kinds of hazardous substances requiring management by using qualitative and quantitative risk assessments. Qualitative risk assessment was performed by multiplying the exposure level class by the hazard class according to the Korea Occupational Safety and Health Agency’s (KOSHA) Chemical Hazard Risk Management (CHARM). The quantitative risk assessment was followed by a four-step risk assessment system presented in the Guidelines for Hazard Risk Assessment of Chemicals (KOSHA GUIDE W-6-2016). In the quantitative assessments, we presented a new method of classifying risk levels into four steps, much like qualitative assessments. In this study, the quantitative risk assessment was considered difficult to predict through qualitative risk assessment. Therefore, it is necessary to perform a quantitative risk assessment after a qualitative risk assessment for a higher level of risk assessment.

1. Introduction

Harmful chemicals used in industrial sites exist in various forms from raw materials to by-products that are produced in the process and the use of these chemicals has steadily increased since the Industrial Revolution [1]. Each year, about 400 new substances are introduced in domestic industrial sites, but most of the direct victims are the workers at these industrial sites who are exposed to these chemicals. Each year, 400 to 500 accidents such as suffocation and addiction from exposure to hazardous chemicals due to lack of awareness or careless handling of harmful chemicals occur in domestic workplaces [2]. In addition, the number of occupational diseases occurring from exposure to harmful substances in Korea has nearly doubled from 1959 in 2015 to 4035 in 2019, and various diseases that are difficult to find causes for in the workplace have become a social problem [3].
Korea’s Occupational Safety and Health Act was revised in January 2020 [4]. These revisions included risk assessment, through which the employer identifies harmful hazards caused by construction, machinery, equipment, raw materials, gas, steam, dust, workers’ work behaviors, or other tasks. The employer is then required to assess whether the magnitude of risk that could lead to injury or illness is within an acceptable range, and to take measures, as per legal requirements, to prevent risks or health problems to their workers [5]. This implies that the risk-generating employer should control to reduce the risk “So Far as Reasonably Practicable” (SFARP) and that all risks have been reduced SFARP [6].
The increasing importance of conducting a risk assessment of hazardous substances in the efficient prevention and management of occupational diseases is due to the scientific basis of setting standards [7]. Risk assessment can provide comprehensive and quantitative information on the effects of exposure to hazardous substances in the workplace on the human body, thereby contributing to the acquisition of trust between workers, employers, and governments, and providing reasonable regulatory standards to establish engineering and administrative management goals. Since risk assessment is essential in the management of hazardous substances, relevant academic organizations have worked hard to establish international regulations; developing technologies for risk assessment methods and international cooperation are also critical tasks [8]. Recently, the Occupational Safety and Health Research Institute has been pushing for a project involving the conduct of risk assessment by obtaining data on hazardous substances that are often used in industrial sites but do not have toxic test data to serve as a basis for chemical management at the national level [9]. By conducting this risk assessment of hazardous substances, we can identify the various hazards present in the workplace, analyze and assess the risks that may arise, and formulate appropriate management measures [10]. In Korea, a quantitative risk assessment method called the “Guidelines for Hazard Risk Assessment of Chemicals (KOSHA GUIDE W-6-2016)” was previously used as a method to assess the risk of chemicals. As a qualitative risk assessment measure, Korea Occupational Safety and Health Agency (KOSHA) developed a chemical qualitative risk assessment method (CHARM) based on the UK’s control banding [4,11,12].
The UK developed control banding for practical management recommendations to help small and medium-sized enterprises (SMEs) with their risk assessment of substances and risk management decisions [13]. The qualitative risk assessment method (CHARM) is easier to perform than the existing quantitative risk assessment method, so it is not only easy for an enterprise to follow, but can also be evaluated without direct measurements. It would be more efficient to use qualitative risk assessment methods if the results of this qualitative risk assessment are comparable to those of quantitative risk assessment methods and if similar results are obtained. Therefore, we tried to compare the results obtained after employing qualitative and quantitative risk assessment methods to 36 kinds of hazardous substances requiring management.

2. Materials and Methods

2.1. Targets of Evaluation

The targets for this study were 36 kinds of hazardous substances requiring management that could help obtain measurement results of the working environment from the KOSHA, as of 2011; information on the 20 substances to be presented as examples is shown in Table 1. Korea is required to measure the working environment approximately twice a year and report the results to the KOSHA. In this study, data on the work environment measurement results for some of the management target substances were used.
It is suggested that the classification labeling of CMR substances is classified according to the standards for classification and labeling of chemical substances and the safety data sheet based on the rules for European Regulation on the Classification, Labeling, and Packaging of substances and mixtures (EU CLP). Accordingly, they are classified into 1A (known to have CMR potential for human is largely based on human evidence), 1B (presumed to have CMR potential for human is largely based on animal evidence), and 2 (suspected human CMR) [4].

2.2. Qualitative Risk Assessment

Qualitative risk assessment followed the CHARM procedure developed by the KOSHA, and its contents are as follows.
If there is a measurement of the working environment for the target substance, the risk is calculated according to the workplace environment result or exposure standards like so:
Risk = Exposure level (Probability) × Hazard level (Severity)
The method of determining the level of exposure in CHARM involves (1) determining whether people had occupational diseases (D1) due to the chemical; when there is an occurrence of occupational diseases, the highest level of exposure level is applied. If there is no occurrence of occupational disease; (2) the work environment measurement results are checked or (3) the handling amount/volatility is checked, and the exposure is classified into one of four levels.
The method for determining the hazard level (severity) involves the following: (1) for CMR substances, the hazard is classified as Grade 4; (2) classifying the severity according to the occupational exposure limit (OEL) based on the Ministry of Employment and Labor in Korea, and (3) classifying the four levels according to the R phrase or H phrase of the Material Safety Data Sheet (MSDS) if a substance does not have OEL. At this time, the probability and the severity are applied in the order of priority Method (1) > Method (2) > Method (3). Risk determination is calculated in 16 grades of risk, as shown in Table 2, according to the exposure and hazard levels, and the level of risk is divided into four levels [14].

2.3. Quantitative Risk Assessment

Quantitative risk assessment involved a four-step risk assessment system for hazard identification, dose-response assessment, exposure assessment, and risk characterization provided by the KOSHA GUIDE W-6-2016. In the dose-response assessment step, appropriate dose-response relationship data based on epidemiological studies and experimental animal data collected in the hazard identification step were used. In the exposure assessment step, the exposure data for each target substance from the 2011 Work Environment Measurement Result, provided by the KOSHA, were used. The central tendency estimate (CTE) and reasonable maximum estimate (RME) for the average daily dose (ADD) and lifetime average daily dose (LADD) for each target substance were calculated using the Monte Carlo Simulation (Crystal ball 11.1, USA). Unit risk (UR) was calculated for 17 carcinogenic substances for which no threshold exist [7,15].
For non-carcinogenic substances, if a threshold exists, the reference dose (RfD) or reference concentration (RfC) was calculated using the no observed adverse effect level (NOAEL) or the lowest observed adverse effect level (LOAEL) as in Equation (2). Based on these values, the workplace reference concentration (RfCwork) was calculated. The hazard quotient (HQ) was calculated by comparing the workplace exposure level values [8].
Human   dose   ( RfC   or   RfD )   =   Experimental   dose   ( NOAEL   or   LOAEL ) UF   ×   MF
where UF is the uncertainty factor, and MF is the modifying factor.

2.4. Comparison of Qualitative and Quantitative Assessment

According to the 2019 Guidelines for Risk Assessment developed by the Ministry of Employment and Labor and the Korea Safety and Health Agency, the level of risk can be subdivided into four levels—very high, high, moderate, and low—through a qualitative risk assessment. According to the KOSHA GUIDE W-6-2016, the risk of carcinogenic or non-carcinogenic substances is determined based on 10−4 and 1, respectively, through quantitative risk assessment [14,15].
In the case of quantitative risk assessments, it is necessary to classify the risk level by subdividing, in a manner like that used in qualitative risk assessment, from a management perspective.
In this study, to compare the results of the qualitative and quantitative assessments, the results of the quantitative evaluation were subdivided into four levels of risk, as in the qualitative assessments, where the grades of risk are shown in Table 2 as well as the classification of the substances included in each stage.
The risk level was classified by the risk value in the qualitative risk assessment, but the quantitative risk value has not yet been classified by level. However, in this study, the level of quantitative risk assessment was classified to compare it with the qualitative risk assessment value.
Potential health effects from exposure to chemicals are usually expressed as HQ or HI. HQ is defined as the ratio of the exposure level of the chemical to the reference concentration as follows:
Hazard   Quotient ,   HQ   =   E RfC
where E is the chemical exposure level (mg/m3) and RfC is the reference concentration (mg/m3).
In the case of the HQ, 1 is the management standard; thus, >1 is classified as very high, 0.5 to 1 as high, 0.1 to 0.5 as moderate, and <0.1 as low. In the case of the Excess Cancer Risk (ECR), the MOEL used 10−4 as the management criterion; thus, the value was divided by 10−4 and evaluated as per the HQ standard.
Table 3 shows that according to the risk assessment guidelines, the risk can be estimated and classified into four levels: low, moderate, high, and very high [12].

3. Results

3.1. Qualitative Risk Assessment

The 2011 results of the work environment measurement for the target substances are shown in Table 4. When the RME was divided by the OELs, most of them were found to be less than 10%, except for vanadium pentoxide. Since most substances are CMR substances, they are sometimes used to minimize exposure as much as possible at the workplace site, and many of the results of work environment measurements have been measured at less than 10%. If the measurement results are less than 10% of the OEL, exposure assessment by CHARM is low at Class 1.
In Table 5, the hazardous substances requiring management are categorized according to the qualitative risk assessment. In the case of the hazard class, 36 substances were CMR materials, thus, they were classified as Class 4. In the case of the exposure class, most of the results of the work environment measurements were less than 10%, thus, they were classified as Class 1. Vanadium pentoxide, having 12.5%, was classified as Class 2. Therefore, the results of the calculation of the risk considering the hazard and exposure level showed that the qualitative risk assessment value was Grade 4 for 35 substances, except for vanadium pentoxide, which was classified as Grade 8.

3.2. Quantitative Risk Assessment

Table 6 shows the results of the quantitative risk assessment of chemical substances requiring management for CTE and RME. As shown in Table 5, there were 17~18 at the low level, eight at the moderate level, four at the high level, and 6~7 at the very high level. The quantitative risk assessment showed that there were seven substances exceeding the HQ values of 1 at the RME level: 1,2,3-Trichloropurophane, ethylene dichloride, 2-methoxyethylacetate, perchloroethylene, nitromethane, pyridine, and vanadium pentoxide. At the CTE level, it was found that six substances, except pyridine, were included. This means that the magnitude of the risk is very high. At the RME level, four substances—acrylonitrile, 1,2-epoxypropane, dichloromethane, cobalt, and their inorganic compounds—had HQ values of 0.5 to 1.0. At the CTE level, four substances were found: acrylonitrile, dichloromethane, pyridine, cobalt, and their inorganic compounds. This can be indicated by the magnitude of the risk being less than 1, but still high. At the RME and CTE levels, the HQ values of 0.1 to 0.5 were shown as diethanolamine, 1,4-dioxane, ethyl acrylate, chlorobenzene, 1,2,2-tetrachloroethane, tetrahydrofuran, 1,1,2-trichloroethylobutone, and eight methyl ketones. These levels were classified as having medium levels of hazard. The HQ values of less than 0.1 were acrylamide, hydrazine, n-hexane, dimethyl aniline, methylene bisphenyl isocyanate, 2-butoxyethanol, methyl bromide, vinyl acetate, cyclohexanone, acetaldehyde, toluene-2,4-diisocyanate, toluene-2,6-diisocyanate, methyl n-butylketone, aniline and homologues, hydrogen peroxide, mercury and its compounds, and titanium dioxide at the RME level. At the CTE level, it was found to be 18 including 1,4-dioxane. It can be said that this level of risk was as low as 10% of the HQ standard 1.

3.3. Comparison of Qualitative and Quantitative Assessments

As shown in Figure 1, according to the results of the qualitative risk assessment, there were 35 substances with moderate risk and one substance with high risk. The results of the quantitative risk assessment revealed that there were eight substances with moderate risk and four substances with high risk. In addition, there were 17 substances with low risk and seven substances with very high risk. As shown in Figure 1, the qualitative risk assessment was found to be relatively evenly distributed compared to the qualitative risk assessment, which showed that most of the work environment measurement results were less than 10%, indicating that it was the first grade. However, because all the substances subject to management were CMR, the hazard level was high, at Grade 5. Eventually, most of the substances were rated as Class 4 for hazard and Class 1 for the possibility of exposure, resulting in a Grade 4 risk. Eventually, it was revealed to be much lower than the highest Grade 16.
On the other hand, the quantitative risk assessment was obtained by dividing the exposure level as per the result of the work environment measurement by the RfD (reference dose) value. Although most work environment measurement results have low values, if the RfD value has a relatively lower value, the HQ value may exceed 1. Therefore, even if the work environment measurement result has a value less than 10% of the OEL, the HQ value may exceed 1 when the RfD value is very low.

4. Discussion

The qualitative risk assessment was based on the Control of Substances Hazardous to Health (COSHH) essentials control banding strategy for Health and Safety Executive (HSE) in the UK. The HSE has developed these programs to help SMEs conduct risk assessment for chemical exposure [16]. In Korea, CHARM was developed based on the British COSHH essential control banding [15]. Control banding, developed in the UK, offers a simple method to manage workers’ exposure to chemicals even without workshop exposure data. Control banding for chemical management provides a user-friendly method for workplace management without reliable toxicological and quantitative exposure information [17]. Paik et al. applied the control banding method to assess and manage the risk level of exposure to nanoparticles [18]. Qualitative risk assessment was performed based on the hazards and handling amounts of chemicals. Yang et al. developed an initial risk assessment database from the GHS database based on the type, degree, and handling amounts of chemical hazards, weighted it, and proposed 12 kinds of priority candidates that required hazard and risk assessment [9].
Since all the substances in this study were CMR, there were no low-risk substances because they were all considered Grade 4 in the qualitative risk assessment. In addition, none of the substances had a very high level of risk because there were no substances with a 50% or higher ratio of work environment measurements to OEL. Vanadium pentoxide, with an exposure level of Class 2 in 12.4%, was calculated as Grade 8, indicating that it was high. Excluding vanadium pentoxide, 35 types of target substances were medium risk of Grade 4, as they were ranked Class 1 in the exposure class. In the case of quantitative risk assessment, the RME of the HQ for seven kinds of substances—1,2,3-trichloropurophane, ethylene dichloride, 2-methoxyethylacetate, perchloroethylene, nitromethane, pyridine, and vanadium pentoxide—exceeded 1, which is likely to have harmful effects on the handling worker. Of the 36 target substances, four were at high risk, eight were at moderate risk, and 17 were at low risk. According to the KOSHA’s CHARM, if the risk level is high or moderate, work should continue, but risk reduction activities should be carried out when there is no current risk. While the qualitative assessments indicated that all 36 types of target substances were high or medium, the quantitative assessment results identified only about 12 substances in these categories (33%). Therefore, we conclude that the quantitative risk level range setting presented in this study lacks feasibility and is less relevant to qualitative and quantitative risk assessments. It will be difficult to predict quantitative risk assessment results through qualitative risk assessments or vice versa.
In addition, since all of the substances included in this study were CMR substances, risk was calculated as Grade 4 in the qualitative evaluation. Therefore, further investigation on non-CMR substances, which are likely to have relatively few hazards, is warranted.
The limitation of this study is that the 36 kinds of target substances were CMR because of the limited range of workplace environment measurement data obtained from KOSHA. Among the chemical substances requiring management, many non-CMR substances exist. Therefore, there is a need to expand and evaluate materials other than CMR. It was found that CHARM, a qualitative risk assessment method, differed from quantitative risk assessment. There is a need for research to narrow this gap and improve the method so that the results are similar to the quantitative risk assessment results.

5. Conclusions

Risk assessment of hazardous substances is increasingly important to efficiently prevent and manage various diseases or accidents caused by increased amounts of hazardous substances in the workplace. In this study, we conducted a risk assessment of 36 kinds of hazardous substances requiring management using both qualitative and quantitative assessment methods. The qualitative risk assessment was performed by multiplying the exposure level class and the hazard class according to the CHARM of the KOSHA. The quantitative risk assessment involved a 4-step risk assessment system presented in the KOSHA GUIDE W-6-2016. In quantitative assessments, we presented a new method of classifying risk levels into four steps, much like qualitative assessments.
Vanadium pentoxide was ranked as Class 2 in the exposure class with a Grade 8 risk, indicating that it was high. Excluding vanadium pentoxide, 35 types of target substances had a moderate risk of Grade 4 as they were ranked as Class 1 in the exposure class. In the case of quantitative risk assessment, seven kinds of substances showed very high-risk levels, four kinds showed high levels, eight kinds showed moderate levels, and 17 kinds showed low risk levels in the workplace exposure level of RME. According to the CHARM, it is stipulated that if the risk level is high or moderate, work should continue, but risk reduction activities should be carried out when there is no current risk. As a result of the qualitative evaluation, all 36 kinds of target substances showed high or moderate risk, but among the quantitative evaluation results, the risk of 12 substances, which was about 33% of the target substances, fell into these categories.
Therefore, the results of this study show that the relationship between the results of the qualitative and quantitative risk assessment of chemical substances requiring management is not high. It is still difficult to predict the result of quantitative risk assessment through qualitative risk assessment or vice versa. After a qualitative risk assessment, a quantitative risk assessment is necessary for a high tier assessment. In addition, there is need for research on how the relationship between assessments in two ways can be enhanced.

Author Contributions

Conceptualization, H.-I.M. and S.-H.B.; Methodology, S.-H.B.; Investigation, S.S.; Data curation, S.-W.H.; Writing—original draft preparation, H.-I.M.; Writing—review and editing, S.-W.H.; Supervision, S.-H.B. All authors have read and agreed to the published version of the manuscript.

Funding

This research was funded by Korea university grant (K1808601).

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

Not applicable.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Kim, S.W.; Choi, C.J.; Phee, Y.G.; Kim, K.B. The Adoption of Risk Assessment Methodology in Exposure Assessment. J. Korean Soc. Occup. Environ. Hyg. 2015, 25, 482–492. [Google Scholar] [CrossRef] [Green Version]
  2. MOEL. 2019 Employment and Labor White Paper; Ministry of Employment and Labor: Sejong-si, Korea, 2019. [Google Scholar]
  3. MOEL. Status of Industrial Accidents; Ministry of Employment and Labor: Sejong-si, Korea, 2015. [Google Scholar]
  4. MOEL. Guidelines for Workplace Risk Assessment; MOEL Notice No. 2020-53; Ministry of Employment and Labor: Sejong-si, Korea, 2020. [Google Scholar]
  5. MOEL. Occupational Safety and Health Act, Related Laws, Enforcement Ordinance, Enforcement Regulations; Ministry of Employment and Labor: Sejong-si, Korea, 2020. [Google Scholar]
  6. Russ, K. Risk Assessment in the UK Health and Safety System: Theory and Practice. Saf. Health Work 2010, 1, 11–18. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  7. Moon, H.I.; Choi, H.I.; Sin, S.M.; Byeon, S.H. Human health risk assessment of n-butyl glycidyl ether from occupational workplaces. J. Korean Soc. Occup. Environ. Hyg. 2013, 23, 20–26. [Google Scholar]
  8. Lim, C.H.; Yang, J.S.; Park, S.Y. A Harmonized Method for Dose-response Risk Assessment Based on the Hazard & Risk Evaluation of Chemicals (HREC) According to the Industrial Safety and Health Act (ISHA). J. Korean Soc. Occup. Environ. Hyg. 2012, 22, 175–183. [Google Scholar]
  9. Yang, J.S.; Lim, C.H.; Park, S.Y. A Study on the Priority for the Hazard and Risk Evaluation of Chemicals (HREC) According to the Industrial Safety and Health Act (ISHA). J. Korean Soc. Occup. Environ. Hyg. 2012, 22, 73–81. [Google Scholar]
  10. Jung, W.J.; Kim, C.N.; Won, J.U.; Kim, K.Y.; Roh, J.H. Health risk assessment for workers exposed to diazinon insecticide. J. Korean Soc. Occup. Environ. Hyg. 2012, 22, 100–106. [Google Scholar]
  11. KOSHA. Guidelines for Evaluating the Hazards and Risks of Chemical Substances; KOSHA GUIDE W-6-2016; Korea Occupational Safety and Health Agency: Ulsan, Korea, 2016. [Google Scholar]
  12. MOEL. Guideline for Risk Assessment; Ministry of Employment and Labor: Sejong-si, Korea, 2019. [Google Scholar]
  13. Brooke, I.M. A UK Scheme to Help Small Firms Control Health Risks from Chemicals: Toxicological Considerations. Ann. Occup. Hyg. 1998, 42, 377–390. [Google Scholar] [CrossRef]
  14. KOSHA. Chemical Hazard Assessment Manual; Korea Occupational Safety and Health Agency: Ulsan-si, Korea, 2012. [Google Scholar]
  15. Asante-Duah, K. Public Health Risk Assessment for Human Exposure to Chemicals; Kluwer Academic Publishers: Dordrecht, The Netherlands, 2002; pp. 43–70. [Google Scholar]
  16. Zalk, D.M.; Kamerzell, R.; Paik, S.; Kapp, J.; Harrington, D.; Swuste, P. Risk Level Based Management System: A Control Banding Model for Occupational Health and Safety Risk Management in a Highly Regulated Environment. Ind. Health 2010, 48, 18–28. [Google Scholar] [CrossRef] [PubMed]
  17. Zalk, D.M.; Heussen, G.H. Banding the World Together; The Global Growth of Control Banding and Qualitative Occupational Risk Management. Saf. Health Work 2011, 2, 375–379. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  18. Paik, S.Y.; Zalk, D.M.; Swuste, P. Application of a Pilot Control Banding Tool for Risk Level Assessment and Control of Nanoparticle Exposures. Ann. Occup. Hyg. 2008, 52, 419–428. [Google Scholar] [PubMed] [Green Version]
Figure 1. Comparison of the results of the qualitative and quantitative risk assessment of the managed substances.
Figure 1. Comparison of the results of the qualitative and quantitative risk assessment of the managed substances.
Ijerph 18 01354 g001
Table 1. Hazards of chemical substances requiring management in a workplace environment.
Table 1. Hazards of chemical substances requiring management in a workplace environment.
No.Substance NameCAS No.CMR * InformationSkin Effect
CarcinogenicityMutagenicityReproductive Toxicity
1Acrylamide79-06-11B1B2Skin
21,2,3-Trichloropropane96-18-41B 1BSkin
3Ethylene dichloride107-06-21B
4Acrylonitrile107-13-11B Skin
52-Methoxyethyl acetate110-49-6 1BSkin
61,2-Epoxypropane75-56-91B1B
7Perchloroethylene127-18-41B
8Hydrazine302-01-21B Skin
9n-Hexane110-54-3 2
10Nitromethane75-52-52
11Dimethylaniline(N,N-Dimethylaniline)121-69-72 Skin
12Diethanolamine111-42-22
131,4-Dioxane123-91-12 Skin
14Dichloromethane75-09-22
15Methylene bisphenyl isocyanate101-68-82
162-Butoxyethanol111-76-22 Skin
17Methyl bromide74-83-9 2 Skin
18Vinyl acetate108-05-42
19Vanadium pentoxide1314-62-1222
20Acetaldehyde75-07-02
* CMR: Carcinogenicity, Mutagenicity, Reproductive toxicity.
Table 2. Classification of risk assessment level.
Table 2. Classification of risk assessment level.
Grades of RiskHazard QuotientPermissible Status
12 to 16Very high>1 Unacceptable
5 to 11High0.5 to 1
3 to 4Moderate0.1 to 0.5Acceptable or Unacceptable (CMR) *
1 to 2Low<0.1Acceptable
* CMR: Carcinogenicity, Mutagenicity, Reproductive toxicity.
Table 3. Estimation of the risk level of chemical substances.
Table 3. Estimation of the risk level of chemical substances.
Hazard LevelVery HighHighModerateLow
Exposure Level Level4321
Very high4161284
High312963
Moderate28642
Low14321
Table 4. Workplace environment measurement results of the target substances.
Table 4. Workplace environment measurement results of the target substances.
No.Substance NameMeasured NumbersExposure Values
(mg/m3)
RME/OEL (%)
CTE *RME **
1Acrylamide4521.56 × 10−41.95 × 10−40.7
21,2,3-Trichloropropane557.41 × 10−18.64 × 10−18.6
3Ethylene dichloride3653.82 × 10−14.55 × 10−14.6
4Acrylonitrile9053.39 × 10−24.11 × 10−22.1
52-Methoxyethyl acetate8719.10 × 10−29.97 × 10−22.0
61,2-Epoxypropane455.17 × 10−26.62 × 10−23.3
7Perchloroethylene23175.59 × 10−17.01 × 10−12.8
8Hydrazine2332.25 × 10−42.77 × 10−40.6
9n-Hexane167547.66 × 10−18.35 × 10−11.7
10Nitromethane169.93 × 10−11.28 × 1006.4
11Dimethylaniline(N,N-Dimethylaniline)682.27 × 10−43.36 × 10−40.0
12Diethanolamine8938.60 × 10−39.65 × 10−32.1
131,4-Dioxane7652.36 × 10−12.96 × 10−11.5
14Dichloromethane76293.01 × 1003.61 × 1000.7
15Methylene bisphenyl isocyanate23951.03 × 10−41.86 × 10−43.7
162-Butoxyethanol86732.59 × 10−13.13 × 10−11.6
17Methyl bromide591.63 × 10−52.34 × 10−50.0
18Vinyl acetate21173.14 × 10−13.63 × 10−13.6
19Vanadium pentoxide386.17 × 10−36.86 × 10−313.7
20Acetaldehyde432.58 × 10−23.28 × 10−21.0
* CTE: central tendency estimates, ** RME: reasonable maximum estimates.
Table 5. Qualitative risk assessment results for hazardous substances requiring management.
Table 5. Qualitative risk assessment results for hazardous substances requiring management.
Grades of RiskQualitative AssessmentPermissible Status
Substances (No.)
12 to 16Very high0Unacceptable
5 to 11High1
3 to 4Medium35Acceptable or Unacceptable (CMR) *
1 to 2Low0Acceptable
* CMR: Carcinogenicity, Mutagenicity, Reproductive toxicity.
Table 6. Results of the quantitative risk assessment of hazardous substances requiring management.
Table 6. Results of the quantitative risk assessment of hazardous substances requiring management.
Grades of RiskSubstances (No.)HQ
CTE *RME **
12~1667>1 × 100
5~11440.5~1
3~4880.1~0.5
1~21817<0.1
* CTE: central tendency estimates, ** RME: reasonable maximum estimates.
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Share and Cite

MDPI and ACS Style

Moon, H.-I.; Han, S.-W.; Shin, S.; Byeon, S.-H. Comparison of the Qualitative and the Quantitative Risk Assessment of Hazardous Substances Requiring Management under the Occupational Safety and Health Act in South Korea. Int. J. Environ. Res. Public Health 2021, 18, 1354. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18031354

AMA Style

Moon H-I, Han S-W, Shin S, Byeon S-H. Comparison of the Qualitative and the Quantitative Risk Assessment of Hazardous Substances Requiring Management under the Occupational Safety and Health Act in South Korea. International Journal of Environmental Research and Public Health. 2021; 18(3):1354. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18031354

Chicago/Turabian Style

Moon, Hyung-Il, Sang-Woo Han, Saemi Shin, and Sang-Hoon Byeon. 2021. "Comparison of the Qualitative and the Quantitative Risk Assessment of Hazardous Substances Requiring Management under the Occupational Safety and Health Act in South Korea" International Journal of Environmental Research and Public Health 18, no. 3: 1354. https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18031354

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop