Cocaine Administration and Its Abstinence Conditions Modulate Neuroglia
Abstract
:1. Introduction
2. Results
2.1. Influence of Cocaine on Transcript Levels
2.2. Alterations in mRNA Expression Induced by Cocaine Self-Administration and Abstinence Conditions
2.3. Alterations in MYRF and PLEK Protein Levels Induced by Cocaine Self-Administration and Abstinence Conditions
3. Discussion
4. Materials and Methods
4.1. Animals
4.2. Cocaine Self-Administration and Extinction Training
4.3. Brain Isolation and RNA Extraction
4.4. Microarray Analyses
4.5. Quantitative Real-Time PCR
4.6. Determination of MYRF and PLEK Protein Concentration
4.7. Statistical Analyses
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
CD86 | cluster of differentiation 86 |
CNP | cyclic nucleotide phosphodiesterase |
CUD | cocaine use disorder |
MAL | myelin and lymphocyte protein |
MYRF | myelin regulatory factor |
PLEK | pleckstrin |
P2RY13 | P2Y purinoceptor 13 |
SUD | substance use disorder |
RGS1 | regulator of G protein signaling 1 |
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Gawlińska, K.; Frankowska, M.; Gawliński, D.; Piechota, M.; Korostyński, M.; Filip, M. Cocaine Administration and Its Abstinence Conditions Modulate Neuroglia. Int. J. Mol. Sci. 2020, 21, 7970. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21217970
Gawlińska K, Frankowska M, Gawliński D, Piechota M, Korostyński M, Filip M. Cocaine Administration and Its Abstinence Conditions Modulate Neuroglia. International Journal of Molecular Sciences. 2020; 21(21):7970. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21217970
Chicago/Turabian StyleGawlińska, Kinga, Małgorzata Frankowska, Dawid Gawliński, Marcin Piechota, Michał Korostyński, and Małgorzata Filip. 2020. "Cocaine Administration and Its Abstinence Conditions Modulate Neuroglia" International Journal of Molecular Sciences 21, no. 21: 7970. https://0-doi-org.brum.beds.ac.uk/10.3390/ijms21217970