Anti-hyperlipidemic Effect of Polyphenol Extract (Seapolynol™) and Dieckol Isolated from Ecklonia cava in in vivo and in vitro Models

A-Reum Yeo; Junglim Lee; In Hwan Tae; Seok-Rae Park; Bong Ho Lee; Hyeon Cheol Shin; Seong Ho Kim; Yung Choon Yoo

주제분류

...

저널정보

한국식품영양과학회
Preventive Nutrition and Food Science 학술저널
Preventive Nutrition and Food Science Vol.17 No.1
2012.3 1 - 7 (7page)

저자정보

A-Reum Yeo (건양대학교)
Junglim Lee (건양대학교)
In Hwan Tae (건양대학교)
Seok-Rae Park (건양대학교)
Bong Ho Lee (한밭대학교)

이용수
내서재: 0

내서재에 추가
되었습니다. 내서재에서
삭제되었습니다.

초록·키워드

오류제보하기

The inhibitory effect of polyphenol extracts (SeapolynolTM, SPN) of the marine brown algae Ecklonia cava and dieckol, a major component of SPN, on hyperlipidemia was investigated in ICR mice fed a high-fat diet (HFD) for five weeks. For analysis of the anti-hyperlipidemic effects of SPN and dieckol, these two agents were given orally on a daily basis to HFD-fed mice for four weeks, starting one week after the beginning of HFD feeding. Groups administered with SPN as well as dieckol showed lower body weight gains than the HFD only group. Administration of SPN and dieckol also resulted in a significant reduction of the level of total cholesterol (TCHO), triglyceride (TG), and low-density lipoprotein (LDL) cholesterol in the serum of HFD-fed mice. In Oil Red O staining using 3T3-L1 preadipocytes, it was shown that both SPN and dieckol markedly inhibited lipid accumulation of 3T3-L1 cells. Furthermore, SPN and dieckol (50 ㎍/mL) significantly inhibited 3-hydroxyl-methyl glutaryl coenzyme A (HMGCoA) reductase activity in vitro. Taken together, these results suggest that polyphenols of Ecklonia cava (SPN) and dieckol reduce body weight gain and fat accumulation in HFD-induced obese mice, and that their hypolipidemic effect is related to the inhibition of adipogenesis of adipocytes and HMGCoA reductase activity.

#hyperlipidemia #Ecklonia cava #Seapolynol™ #polyphenols #dieckol