Association between Dietary Acid Load and Insulin Resistance : Tehran Lipid and Glucose Study :Tehran Lipid and Glucose Study

Sajjad Khalili Moghadam; Zahra Bahadoran; Parvin Mirmiran; Maryam Tohidi; Fereidoun Azizi

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Tehran Lipid and Glucose Study

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한국식품영양과학회
Preventive Nutrition and Food Science 학술저널
Preventive Nutrition and Food Science Vol.21 No.2
2016.6 104 - 109 (6page)

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Sajjad Khalili Moghadam (Shahid Beheshti University of Medical Sciences)
Zahra Bahadoran (Shahid Beheshti University of Medical Sciences)
Parvin Mirmiran (Shahid Beheshti University of Medical Sciences)
Maryam Tohidi (Shahid Beheshti University of Medical Sciences)
Fereidoun Azizi (Shahid Beheshti University of Medical Sciences)

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In the current study, we investigated the longitudinal association between dietary acid load and the risk of insulin resistance (IR) in the Tehranian adult population. This longitudinal study was conducted on 925 participants, aged 22∼80 years old, in the framework of the third (2006∼2008) and fourth (2009∼2011) phases of the Tehran Lipid and Glucose Study. At baseline, the dietary intake of subjects was assessed using a validated semi-quantitative food frequency questionnaire, and the potential renal acid load (PRAL) and net endogenous acid production (NEAP) scores were calculated at baseline. Fasting serum insulin and glucose were measured at baseline and again after a 3-year of follow-up; IR was defined according to optimal cut-off values. Multiple logistic regression models were used to estimate the risk of IR according to the PRAL and NEAP quartile categories. Mean age and body mass index of the participants were 40.3 years old of 26.4 ㎏/㎡, respectively. Mean PRAL and NEAP scores were −11.2 and 35.6 mEq/d, respectively. After adjustment for potential confounders, compared to the lowest quartile of PRAL and NEAP, the highest quartile was accompanied with increased risk of IR [odds ratio (OR)=2.81, 95% confidence interval (CI)=1.32∼5.97 and OR=2.18, 95% CI=1.03∼4.61, respectively]. Our findings suggest that higher acidic dietary acid-base load, defined by higher PRAL and NEAP scores, may be a risk factor for the development of IR and related metabolic disorders.

#dietary acid-base load #potential renal acid load #insulin resistance