Vitis vinifera L. Grape Skin Extract Prevents Development of Hypertension and Altered Lipid Profile in Spontaneously Hypertensive Rats: Role of Oxidative Stress.

Giselle França da Costa; Dayane Teixeira Ognibene; Cristiane Aguiar da Costa; Michelle Teixeira Teixeira; Viviane da Silva Cristino Cordeiro; Graziele Freitas de Bem; Aníbal Sanchez Moura; Angela de Castro Resende; Roberto Soares de Moura

doi:10.3746/pnf.2020.25.1.25

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한국식품영양과학회
Preventive Nutrition and Food Science 학술저널
Preventive Nutrition and Food Science Vol.25 No.1
2020.3 25 - 31 (7page)
DOI : 10.3746/pnf.2020.25.1.25

저자정보

Giselle França da Costa (Rio de Janeiro State University)
Dayane Teixeira Ognibene (Rio de Janeiro State University)
Cristiane Aguiar da Costa (Rio de Janeiro State University)
Michelle Teixeira Teixeira (Federal University of the State of Rio de Janeiro)
Viviane da Silva Cristino Cordeiro (Rio de Janeiro State University)

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This study investigated the protective effect of a Vitis vinifera L. grape skin extract (ACH09) on blood pressure, lipid profile, and oxidative status in spontaneously hypertensive rats (SHR). Systolic blood pressure (SBP), total cholesterol, triglyceride, and glucose levels, as well as oxidative damage and antioxidant activity in the plasma and kidney, were evaluated in four experimental groups: control Wistar rats (W-C) and SHR-C that received water, and Wistar rats and SHR treated with ACH09 (200 mg/kg/d) in drinking water for 12 weeks (W-ACH09 and SHR-ACH09, respectively). SBP increased in the SHR group compared with the W groups and the treatment with ACH09 prevented the development of hypertension. Plasma triglyceride and total cholesterol levels increased in SHR compared with W-C rats; these changes prevented by treatment with ACH09. Glucose levels did not differ between the groups. The SHR group had increased oxidative damage in plasma, as expressed by 2-thiobarbituric acid reactive substances (TBARS) levels, and this prevented by ACH09. Levels of TBARS in the kidneys were lower in the SHR-ACH09 group than in the SHR-C group. Further, ACH09 increased the superoxide dismutase activity in both the plasma and kidneys of both SHR and Wistar rats. These results suggest that ACH09 is protective against disruption of blood pressures, oxidant status, and lipid profile in SHR, and provide important evidence on the benefits of ACH09 on hypertension and associated cardiovascular complications.

#grape skin extract #hypertension #oxidative stress #spontaneously hypertensive rats