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Volume 71
Issue 2
10.3797/scipharm.aut-03-08
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Article

Synthesis and in vitro Anti-HIV Screening of Certain 2-(Benzoxazol-2-ylamino)-3H-4-oxopyrimidines

by
Sherif A. F. Rostom
1,*,
Hesharn T. Y. Fahmy
2 and
Manal N. Ssaudi
3
1
Division of Medicinal Chemistry, Faculty of Medicine and Allied Sciences, King Abdul-Aziz University, P.O. Box 80205, Jeddah 2 1589, Kingdom Saudi Arabia
2
School of Pharmacy, University of Mississippi, Mississippi 38677, USA
3
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, 2 12 15 Alexandria, A. R. Egypt
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2003, 71(2), 57-74; https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.aut-03-08
Submission received: 8 January 2003 / Revised: 14 March 2003 / Accepted: 14 March 2003 / Published: 14 April 2003
Versions Notes

Abstract

Intensive efforts are underway worldwide to develop chemotherapeutic agents effective against HIV, the etiological agent of AIDS. In this view, it was designed to synthesize and investigate the anti-HIV activity of some new 2-(benzoxazol-2-ylamino)-3H-4-oxopyrimidines following the lead benzoxazole (L 697, 661), which was reported to inhibit the spread of the HIV infection by 95 % in MT4 cell culture. Only the 2-(benzoxazol-2-ylarnino)-6-hydroxy-3H-4-oxopyrdine 8 (NSC 722448) was confirmed to exhibit moderate in vitro anti-HIV activity (percentage of protection 76.83 %).
Keywords: HIV; AIDS; Benzoxazoles; Pyrimidines; Anti-HIV screening HIV; AIDS; Benzoxazoles; Pyrimidines; Anti-HIV screening

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MDPI and ACS Style

Rostom, S.A.F.; Fahmy, H.T.Y.; Ssaudi, M.N. Synthesis and in vitro Anti-HIV Screening of Certain 2-(Benzoxazol-2-ylamino)-3H-4-oxopyrimidines. Sci. Pharm. 2003, 71, 57-74. https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.aut-03-08

AMA Style

Rostom SAF, Fahmy HTY, Ssaudi MN. Synthesis and in vitro Anti-HIV Screening of Certain 2-(Benzoxazol-2-ylamino)-3H-4-oxopyrimidines. Scientia Pharmaceutica. 2003; 71(2):57-74. https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.aut-03-08

Chicago/Turabian Style

Rostom, Sherif A. F., Hesharn T. Y. Fahmy, and Manal N. Ssaudi. 2003. "Synthesis and in vitro Anti-HIV Screening of Certain 2-(Benzoxazol-2-ylamino)-3H-4-oxopyrimidines" Scientia Pharmaceutica 71, no. 2: 57-74. https://0-doi-org.brum.beds.ac.uk/10.3797/scipharm.aut-03-08

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