Abstract: In PRRSV-infected farms occurs increase of female culling rate, mainly due to reproductive problems and culling of young females. This has significant economic importance as the low female culling rate is an important management factor. In the present study in a farrow-to-finish farm with 1,100 sows, all gilts and sows were vaccinated with a PRRS-inactivated vaccine PROGRESSIS^®/Merial SAS, France) for a period of 18 months. For each gilt and sow, reproductive data were collected starting from 1 year prior until 18 months after the start of vaccination. Culling rate and the causes of culling (reproductive failure, death, old age, locomotor problems and other) were recorded. Blood samples from non-vaccinated animals were collected prior and after the start of vaccination. The purpose of this field study was to evaluate the sow longevity in a PRRSV-infected farm after their long-term vaccination with an inactivated PRRSV vaccine. The results indicated that the vaccination lead to a significant reduction (p<0.001) of culling rate due to reproductive failure 1.5 years after the start of vaccination and an increase of old age (sows with completion of 8 reproductive cycles) (p<0.001) totally 1.5 years after the start of vaccination. Eventually, culling rates due to deaths (p = 0.066), locomotor problems (p = 0.264) and other causes (p = 0.894) did not significant differ per semester and totally prior and after the start of vaccination. In conclusion, the long-term vaccination of breeding stock with an inactivated PRRSV vaccine can lead to decrease of culling rate due to reproductive failure and improvement of the sow longevity.