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    Infect Chemother. 2010 Jun;42(3):156-161. Korean.
    Published online Jun 30, 2010.
    https://doi.org/10.3947/ic.2010.42.3.156
    Copyright © 2010 by The Korean Society of Infectious Diseases and The Korean Society for Chemotherapy
    Original Article

    Clinical Features of Invasive Pneumococcal Disease in Korea

    Won Suk Choi, Ji Yun Noh, Joong Yeon Huh, Young Kyoung Youn, Mi Jeong Kim, Yu Mi Jo, Jeong Yeon Kim, Joon Young Song, Dae Won Park, Woo Joo Kim, Min Ja Kim and Hee Jin Cheong
      • Division of Infectious Disease, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
    • Corresponding author: Hee Jin Cheong, M.D. Division of Infectious Disease, Department of Internal Medicine, Korea University College of Medicine, Korea University Guro Hospital, 97, Gurodong-gil, Guro-gu, Seoul 152-703, Korea. Tel: +82-2-2626-3050, Fax: +82-2-2626-1105, Email: heejinmd@korea.ac.kr
    Received September 03, 2009; Revised March 16, 2010; Accepted March 22, 2010.

    This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Abstract

    Background

    Streptococcus pneumoniae is one of the most important causes of pneumonia, meningitis, bacteremia, and other invasive diseases in children and adults. The 23-valent polysaccharide pneumococcal vaccine (PPV) has been recommended to adults with high risk conditions by the Korea Society of Infectious Diseases in 2007, but there is no data on the epidemiology of invasive pneumococcal disease in Korean adults to support this recommendation. Therefore, we performed a study to investigate the epidemiology of invasive pneumococcal disease in Korean population.

    Materials and Methods

    We collected clinical and microbiologic data of patients diagnosed with invasive pneumococcal disease (IPD) in 3 university-hospitals located in Seoul and Gyeonggi-do from January 2002 to December 2007.

    Results

    A total of 168 patients were diagnosed with IPD in the selected hospitals during the study period. Invasive pneumonia and meningitis were the most common forms of IPDs. The mean length of hospitalization of patients with IPD was 18.5±26.7 days and mortality rate of IPD was 18.6%. Among the isolates from patients with IPD, 59.7% was susceptible to penicillin and 38.3% was susceptible to erythromycin. Mortality rate of IPD increased with age and in patients with Eastern Cooperative Oncology Group performance status 4.

    Conclusions

    Epidemiology of IPD in Korean population was described. Further studies should be performed to secure the risk factors of invasive pneumococcal diseases and to confirm the appropriateness of recommendation for vaccination with the 23-valent PPV.

    Keywords
    Streptococcus pneumoniae; Pneumococcal infections; epidemiology

    Figures

    Figure 1
    Age distribution of cases with invasive pneumococcal disease (IPD) in 3 university hospitals in Korea from January 2002 to December 2007.

    Figure 2
    Distribution of clinical diagnoses of invasive pneumococcal disease (IPD) in 3 university hospitals in Korea from January 2002 to December 2007.

    Figure 3
    Antibiotic susceptibility of pneumococci isolated from patients with invasive pneumococcal disease in 3 university hospitals in Korea from January 2002 to December 2007. Some isolates did not have the result of susceptibility test to specific antibiotics in medical records. Among a total of 168 isolates, 164 (97.6%) had the result of susceptibility test to penicillin, 154 (91.7%) had the result of susceptibility test to erythromycin, 120 (71.4%) had the result of susceptibility test to cefotaxime, and 153 (91.1%) had the result of susceptibility test to levofloxacin.

    Tables

    Table 1
    Distribution of Invasive Pneumococcal Disease according to Age Group

    Table 2
    Underlying Medical Conditions of Patients with Invasive Pneumococcal Disease according to Age Group

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    MeSH Terms
    Adult
    Bacteremia
    Child
    Communicable Diseases
    Erythromycin
    Hospitalization
    Humans
    Korea
    Meningitis
    Penicillins
    Pneumococcal Infections
    Pneumonia
    Risk Factors
    Streptococcus pneumoniae
    Vaccination
    Metrics
    Share
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