Biocompatible Microcapsule of Carboxymethyl Cellulose/Chitosan as Drug Carrier

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Abstract:

The biocompatible microcapsule of carboxymethyl cellulose/chitosan is obtained through two steps: firstly, carboxymethyl cellulose (CMC) and chitosan (CS) layer-by-layer self-assemble onto melamine formaldehyde (MF) microspheres; secondly, MF template is removed. The electrostatic interaction between CMC and CS, solution ionic strength and growth of LbL membrane are investigated by IR spectra and UV-vis spectra. The morphology and size of hollow microcapsules is observed by SEM and TEM. The results show that the hollow microcapsules are spherical shape with a little distortion and the shell average thickness of one bilayer of CMC/chitosan polyelectrolyte complex was 25 nm. The result for drug delivery and release experiments, tetracycline is as the drug model, shows that tetracycline is encapsulated with a high drug loading efficiency and could be sustained release.

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227-236

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July 2015

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[1] Shan W.Q., Bacchin P., Aimar P., Bruening M.L., Tarabara V.V., Polyelectrolyte multilayer films as backflushable nanofiltration membranes with tunable hydrophilicity and surface charge, Journal of Membrane Science, 349(2010) 268-278.

DOI: 10.1016/j.memsci.2009.11.059

Google Scholar

[2] Yang J. H, Yang B., Based on the self-assembly colloidal crystal constructing orderly microstructures, Science in China, 54 (2009) 717-728.

Google Scholar

[3] Anton M. P., Gleb B. S., David J. G., Lessons in microcapsule assembly from Imaging delivery of a bioluminescent enzyme, Biomacromolecules, 14(2013)608−612.

DOI: 10.1021/bm3019054

Google Scholar

[4] Cheng P., Guan J., Zhang H., Preparation and application of fluoroquinolones-loaded sustained-release chitosan microspheres, Journal of Clinical Rehabilitative Tissue Engineering Research, 13(2009) 3193-3196.

Google Scholar

[5] Rokhade A.P., Agnihotri S. A, Patil S.A., Mallikarjuna N.N., Kulkarni P.V., Aminabhavi T.M., Semi-interpenetrating polymer network microspheres of gelatin and sodium carboxymethyl cellulose for controlled release of ketorolac tromethamine, Carbohydrate Polymers, 65(2006).

DOI: 10.1016/j.carbpol.2006.01.013

Google Scholar

[6] Geest B.D., Willart M. A., Hammad H., Lambrecht B.N., Pollard C., Bogaert P., Filette M.D., Saelens X., Vervaet C., Remon J.P., Grooten J., Koker S.D., Polymeric multilayer capsule-mediated vaccination induces protective immunity against cancer and viral infection, ACS Nano, 6(2012).

DOI: 10.1021/nn205099c

Google Scholar

[7] Deng R.H., Liang F.X., Li W.K., Yang Z.Z., Zhu J.T., Reversible transformation of nanostructured polymer particles, Macromolecules, 46 (2013) 7012–7017.

DOI: 10.1021/ma401398h

Google Scholar

[8] Xu W.N., Choi I., Plamper F. A., Synatschke C.V., Müller A.H.E., Tsukruk V.V., Nondestructive Light-Initiated Tuning of Layer-by-Layer Microcapsule Permeability, ACS Nano, 7(20131) 598–613.

DOI: 10.1021/nn304748c

Google Scholar

[9] Xiong M.J., Li X.F., Huang S.H., Xu X.L., Xie Y., Hong X.W., Biocompatibility of sustained-releasing microspheres loading chitosan scaffolds, Journal of Clinical Rehabilitative Tissue Engineering Research, 51(2010)9577-9581.

Google Scholar

[10] Ni S. B, Li Y.B., Wang X.M., Preparation, application and functionalization of hydroxyapatite microspheres, Progress in Chemistry, 23(2010) 231-245.

Google Scholar

[11] Ge Y.F., Li M.C., Xin M.H., Chitosan beads bearing β-cyclodextrin, the preparation and adsorption study for dinitrophenol, Chemical Industy and Engineering Progress, 29(2010) 233-237.

Google Scholar

[12] LuoY. L, Yao X. J, Yuan J. F, Ding T., Gao Q.Y., Preparation and drug controlled-release of polyion complex micelles as drug delivery systems, Colloids and Surfaces B: Biointerfaces, 68(2009)218-224.

DOI: 10.1016/j.colsurfb.2008.10.014

Google Scholar

[13] Yang W.J., Wang T., He N.Y., Preparation and property of chitosan/sodium tripolyphosphate microcapsules as drug carrier, Chemical Journal of Chinese Universities, 3(2009) 625-628.

Google Scholar

[14] Buseher K, Graf K, Ahrens H., Influence of adsorption conditions on the structure polyelectrolyte multilayers, Langmuir, 18(2002)3585-3591.

DOI: 10.1021/la011682m

Google Scholar