Oxidized dextran/amino gelatin/hyaluronic Acid Semi-Interpenetrating Network Hydrogels for Tissue Engineering Application

Xiao Hua Geng; Liu Yuan; Xiu Mei Mo

doi:10.4028/www.scientific.net/AMR.627.745

Paper Titles

Initiator Concentration Effect on Rheological Properties of a pH-Sensitive Semi-IPN Hydrogel Based on Konjac Glucomannan and Methacrylic Acid
p.730

Mechanical Properties of Fir Sawdust Composite Modified by Basalt Glass Powder
p.734

Optimization Process and Characteristic Evaluations of Pro-Environmental Recycled PET Composite Geotextiles
p.737

Osteoblasts Express More Collagen I and Osteocalcin on Extracellular Matrix Patterns
p.741

Oxidized dextran/amino gelatin/hyaluronic Acid Semi-Interpenetrating Network Hydrogels for Tissue Engineering Application
p.745

Polylactic Acid Bone Scaffolds Made by Heat Treatment
p.751

Preparation and Anti-Scratch Property of Supersonic-Particles-Deposited Coating on Magnesium Alloy
p.756

Preparation and Characterization of MWCNT/Ultrahigh-Molecular-Weight Polyethylene Composite Fiber
p.761

Preparation and Release Behavior of Polyelectrolyte Microcapsules
p.765

HomeAdvanced Materials ResearchAdvanced Materials Research Vol. 627Oxidized dextran/amino gelatin/hyaluronic Acid...

Oxidized dextran/amino gelatin/hyaluronic Acid Semi-Interpenetrating Network Hydrogels for Tissue Engineering Application

Abstract:

In our previous study, oxidized dextran/amino gelatin (ODex/MGel) self-crosslinking hydrogels have been successfully prepared. Though their potential applications as in situ forming scaffolds for tissue engineering have been verified, the subcellular porosities of hydrogel networks which were induced by the intensity chemical crosslinking still pose a barrier for cells migration and proliferation within the hydrogels. The objective of this study was to develop an approach to accelerate cellular remodeling by preparing semi-interpenetrating networks (semi-IPNs) composed of ODex, MGel, and sodium hyaluronic (HA). Results showed that the addition of HA at the concentrations of 0.09% and 0.18% can greatly promote pre-osteoblast (MC3T3-E1) cells spreading throughout the ODex/MGel hydrogel networks. Therefore, these semi-IPNs hydrogels could be useful matrixes for cell transplantation in a variety of tissue engineering applications.

You might also be interested in these eBooks

Advances in Textile Engineering and Materials

View Preview

Info:

Periodical:

Advanced Materials Research (Volume 627)

Pages:

745-750

DOI:

https://doi.org/10.4028/www.scientific.net/AMR.627.745

Citation:

Cite this paper

Online since:

December 2012

Authors:

Xiao Hua Geng, Liu Yuan, Xiu Mei Mo

Keywords:

Dextran, Gelatin, Hyaluronic, Hydrogel, Semi-Interpenetrating

Export:

RIS, BibTeX

Price:

Permissions:

Request Permissions

References

[1] M.P. Lutolf and J.A. Hubbell: Nat Biotech Vol. 23 (2005), p.47

Google Scholar

[2] M.L. Mather and P.E. Tomlins: Regenerative Medicine Vol. 5 (2010), p.809

Google Scholar

[3] M.W. Tibbitt and K.S. Anseth: Biotechnology and Bioengineering Vol. 103 (2009), p.655

Google Scholar

[4] N. Bhattarai, J. Gunn and M. Zhang: Advanced Drug Delivery Reviews Vol. 62 (2010), p.83

Google Scholar

[5] E.A. Phelps, N.O. Enemchukwu, V.F. Fiore, J.C. Sy, N. Murthy, T.A. Sulchek, T.H. Barker and A.J. García: Advanced Materials Vol. 24 (2012), p.2

Google Scholar

[6] H. Park, J.S. Temenoff, Y. Tabata, A.I. Caplan, R.M. Raphael, J.A. Jansen and A.G. Mikos: Journal of Biomedical Materials Research Part A Vol. 88A (2009), p.889

DOI: 10.1002/jbm.a.31948

Google Scholar

[7] G.M. Cruise, D.S. Scharp and J.A. Hubbell: Biomaterials Vol. 19 (1998), p.1287

Google Scholar

[8] J.K. Kutty, E. Cho, J. Soo Lee, N.R. Vyavahare and K. Webb: Biomaterials Vol. 28 (2007), p.4928

Google Scholar

[9] X. Mo, H. Iwata, S. Matsuda and Y. Ikada: Journal of Biomaterials Science, Polymer Edition Vol. 11 (2000), p.341

Google Scholar

[10] J. Maia, L. Ferreira, R. Carvalho, M.A. Ramos and M.H. Gil: Polymer Vol. 46 (2005), p.9604

Google Scholar

[11] J.A. Benton, B.D. Fairbanks and K.S. Anseth: Biomaterials Vol. 30 (2009), p.6593

Google Scholar

[12] S.R. Peyton, C.B. Raub, V.P. Keschrumrus and A.J. Putnam: Biomaterials Vol. 27 (2006), p.4881

Google Scholar