Study of Alkylglycerol Containing Shark Liver Oil: A Physico Chemical Support for Biological Effect

Authors

  • Jean-Claude Debouzy Unité BCM Centre de Recherches du Service Santé des Armées, 24, avenue des maquis du Grésivaudan, BP 87-38 702 La Tronche Cedex, France.
  • David Crouzier Unité BCM Centre de Recherches du Service Santé des Armées, 24, avenue des maquis du Grésivaudan, BP 87-38 702 La Tronche Cedex, France.
  • Bertrand Lefebvre Unité de Biospectrométrie Centre de Recherches du Service Santé des Armées, 24, avenue des maquis du Grésivaudan, BP 87-38 702 La Tronche Cedex, France.
  • Vincent Dabouis Unité BCM Centre de Recherches du Service Santé des Armées, 24, avenue des maquis du Grésivaudan, BP 87-38 702 La Tronche Cedex, France.

DOI:

https://doi.org/10.33393/dti.2008.1323

Keywords:

alkylglycerol, membrane fluidity, ESR, NMR, anti oxidant properties

Abstract

Shark liver oil (SLO), is used in natural medicine as immunity stimulant, cardiovascular protector and anti ageingreagent. These properties were related with the high amounts of alkylglycerols (22%) obtained from Greenland shark liver. After a control of the mean SLO composition by NMR and MS, surface and membrane interactions and antioxidant properties were investigated using NMR, ESR and ST measurements and the in vitro consequences on erythrocytes and cells were studied. An estimation of the composition of this extract was performed. Moreover, SLO was found not haemolytic (A concentration inducing 50% haemolysis, HC50 could not be reached) and superficial tension measurements revealed slight tension active properties. The 31P and 2H-NMR and ESR studies of phospholipid dispersions (dimyristoyl phosphatidyl cholin, DMPC) in the presence of SLO showed a significant increase in membrane fluidity at low temperature (below phase transition temperature) predominantly observed at the surface level. The anti oxidant activity was also confirmed, similar as that observed for vitamin E.

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Published

2008-05-28

How to Cite

Debouzy, J.-C., Crouzier, D., Lefebvre, B., & Dabouis, V. (2008). Study of Alkylglycerol Containing Shark Liver Oil: A Physico Chemical Support for Biological Effect. Drug Target Insights, 3(1). https://doi.org/10.33393/dti.2008.1323

Issue

Vol. 3 No. 1 (2008): January-December 2008

Section

Original Research Article

License

Authors contributing to Drug Target Insights agree to publish their articles under the Creative Common Attribution Non Commercial 4.0 (CC-BY-NC 4.0) license, which allows third parties to re-use the work without permission as long as the work is properly referenced and the use is non-commercial.

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