Home Neoplasma 2018 Neoplasma Vol.65, No.3, p.317-325, 2018

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Founded: 1954
ISSN 0028-2685
ISSN 1338-4317 (online)

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Neoplasma Vol.65, No.3, p.317-325, 2018

Title: Neovascularization in Ewing’s sarcoma
Author: A. F. MAVROGENIS, C. T. VOTTIS, P. D. MEGALOIKONOMOS, G. D. AGROGIANNIS, S. THEOCHARIS

Abstract: Ewing’s sarcoma is the second most common bone malignancy in adolescents and young adults after osteosarcoma. Similar to other solid tumors, Ewing’s sarcomas require an adequate vascular supply to grow and survive. The development and maintenance of vascular supply is accomplished via three main mechanisms; angiogenesis, vasculogenesis, and tumor cell vasculogenic mimicry. In addition, growth factors, parallel biochemical pathways and the tumor microenvironment are implicated in the initiation and maintenance of neovascularization. This article summarizes the different mechanisms and factors that contribute to neovascularization in Ewing’s sarcoma, and discusses the significance of this phenomenon for current treatment options.

Keywords: sarcoma, Ewing, angiogenesis, vasculogenesis
Published online: 16-May-2018
Year: 2018, Volume: 65, Issue: 3 Page From: 317, Page To: 325
doi:10.4149/neo_2018_170410N264


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