Open Access, Peer-reviewed
pISSN 1015-4817
eISSN 2289-0963
    J Korean Neuropsychiatr Assoc. 2012 Sep;51(5):285-290. Korean.
    Published online Sep 30, 2012.
    https://doi.org/10.4306/jknpa.2012.51.5.285
    Copyright © 2012 Korean Neuropsychiatric Association
    Original Article

    Neurocognitive Function Impairment in Alcohol Dependent Patients with Diabetes Mellitus

    Hye-Rim Hwang, MD,1 Jung-Ah Min, MD,1 Min Kwon, MS,2 Young-Hoon Cheon, MD,3 Jae-Woo Park, MA,4 Sook-Hee Chai, PhD,5 and Dai-Jin Kim, MD, PhD1,2
      • 1Department of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Korea.
      • 2Addiction Clinic, Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
      • 3Department of Psychiatry, Incheon Chamsarang Hospital, Incheon, Korea.
      • 4Department of Psychology, The Catholic University of Korea College of Social Science, Bucheon, Korea.
      • 5Department of Addiction Rehabilitation with Social Welfare, Eulji University of Korea, Seongnam, Korea.
    • Address for correspondence: Dai-Jin Kim, MD, PhD. Department of Psychiatry, The Catholic University of Korea College of Medicine, 222 Banpo-daero, Seocho-gu, Seoul 137-701, Korea. Tel +82-2-2258-6086, Fax +82-2-594-3870, Email: kdj922@catholic.ac.kr
    Received June 18, 2012; Revised July 02, 2012; Accepted July 18, 2012.

    Abstract

    Objectives

    Diabetes and alcohol dependence are considered as independent risk factors for cognitive impairment. This research was to investigate whether cognitive functions in diabetic alcohol dependent patients were more impaired than non-diabetic alcohol dependent patients.

    Methods

    A cross-sectional study was conducted in alcohol dependence patients (n=138). Patients with alcohol dependence diagnosed by Diagnostic and Statistical Manual of Mental Disorder, 4th edition, Text Revision underwent a 75 g oral glucose tolerance test, to classify to diabetics group and non-diabetics group. In addition to demographic and clinical characteristics, cognitive functions assessed using the Korean-Mini Mental Status Examination (K-MMSE), word list memory test, and word fluency test, word list recall test from Korean version of the consortium to establish a registry for Alzheimer's disease, and block design test, digit span test, and digit symbol test from Korean-Wechsler Adult Intellogence Scale were compared between the two groups.

    Results

    There was no significant difference in demographic and other clinical characteristics between the non-diabetic and diabetic alcoholic patients. Compared to non-diabetic alcoholic patients, diabetic alcoholic patients were more impaired on language of K-MMSE (p=0.028) and digit symbol test (p=0.044).

    Conclusion

    These findings suggest the more severe impairment of selective cognitive functions in diabetic alcoholic patients than non-diabetic alcoholic patients. Future replication of these findings in a large population is necessary.

    Keywords
    Alcohol dependence; Diabetes; Comorbidity; Cognition

    Tables

    Table 1
    Demographic and clinical characteristics of nondiabetic- and diabetic-alcoholic patients

    Table 2
    Comparison of neuropsychological test results between diabetic alcohol dependent patients and non-diabetic alcohol dependent patients

    Notes

    The authors have no financial conflicts of interest.

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    MeSH Terms
    Adult
    Alcoholics
    Alcoholism
    Alzheimer Disease
    Cognition
    Comorbidity
    Cross-Sectional Studies
    Diabetes Mellitus
    Glucose Tolerance Test
    Humans
    Memory
    Mental Disorders
    Risk Factors
    Metrics
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