ABSTRACT

Cancer is regarded as one of the most dangerous diseases despite the advances in technology and therapeutic strategies against it. The current treatment strategies are ineffective as well as present with various disadvantages, such as drug resistances, ineffective uptake of the therapeutic agents at the tumor site, incompatible delivery of drugs, and immune-rejection, among others. Extracellular vesicles, especially exosome mimetic nanovesicles, have become one of the latest focuses of research in anticancer therapies. The invention of these nano-sized vesicles, which function in cell-to-cell communication, have promoted the development of innovative drug delivery systems due to their cargo-carrying abilities and targeted deliveries. Exosome mimetic nanovesicles have similar surface protein structures to exosomes and offer various important advantages over the exosomes, such as the production yield and isolation protocol. This review aims to summarize the current research studies on exosome mimetic nanovesicles together with their potential in combating cancer in the future.

Keywords: Cancer, cancer therapy, exosomes, nanovesicles