Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005, 149(2):461-463 | DOI: 10.5507/bp.2005.080

ANTIPROLIFERATIVE ACTIVITY OF BERBERINE IN VITRO AND IN VIVO

Silvia Letašiová^a, Soňa Jantová^a, Marta Múčková^b, Marica Theiszová^a

^a Department of Biochemistry and Microbiology, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, SK-81237 Bratislava, Slovak Republic

^b Drug Research Institute, Horná 36, SK-90001 Modra, Slovak Republic

Berberine, an isoquinoline plant alkaloid acted cytotoxically in vitro on tumour cell lines B16. Its anticancer activity in vivo was studied with the transplanted B16 line in the range of doses from 1 mg/kg to 10 mg/kg. The significant reduction of tumor volume was observed on day 16 at doses of 5 and 10 mg/kg. The dose of 1 mg/kg stimulated the tumor mass, but other tested concentration, 5 and 10 mg/kg, reduced the tumor weight.

Keywords: Berberine, B16 cells, C57BL, 6 mice, Antiproliferative activity

Received: June 10, 2005; Accepted: September 25, 2005; Published: December 1, 2005  Show citation