Proposed Guidelines for Hypertriglyceridemia in Japan with Non-HDL Cholesterol as the Second Target

Hitoshi Shimano; Hidenori Arai; Mariko Harada-Shiba; Hirotsugu Ueshima; Takao Ohta; Shizuya Yamashita; Takanari Gotoda; Yutaka Kiyohara; Toshio Hayashi; Junji Kobayashi; Kazuaki Shimamoto; Hideaki Bujo; Shun Ishibashi; Koji Shirai; Shinichi Oikawa; Yasushi Saito; Nobuhiro Yamada

doi:10.5551/jat.E560

Opinion

Proposed Guidelines for Hypertriglyceridemia in Japan with Non-HDL Cholesterol as the Second Target

Hitoshi Shimano, Hidenori Arai, Mariko Harada-Shiba, Hirotsugu Ueshima, Takao Ohta, Shizuya Yamashita, Takanari Gotoda, Yutaka Kiyohara, Toshio Hayashi, Junji Kobayashi, Kazuaki Shimamoto, Hideaki Bujo, Shun Ishibashi, Koji Shirai, Shinichi Oikawa, Yasushi Saito, Nobuhiro Yamada

Author information

Hitoshi Shimano
The Research Committee for Primary Hyperlipidemia, Research on Measures for Intractable Diseases by the Ministry for Health, Labor, and Welfare in Japan.
Hidenori Arai
The Research Committee for Primary Hyperlipidemia, Research on Measures for Intractable Diseases by the Ministry for Health, Labor, and Welfare in Japan.
Mariko Harada-Shiba
The Research Committee for Primary Hyperlipidemia, Research on Measures for Intractable Diseases by the Ministry for Health, Labor, and Welfare in Japan.
Hirotsugu Ueshima
The Research Committee for Primary Hyperlipidemia, Research on Measures for Intractable Diseases by the Ministry for Health, Labor, and Welfare in Japan.
Takao Ohta
The Research Committee for Primary Hyperlipidemia, Research on Measures for Intractable Diseases by the Ministry for Health, Labor, and Welfare in Japan.
Shizuya Yamashita
The Research Committee for Primary Hyperlipidemia, Research on Measures for Intractable Diseases by the Ministry for Health, Labor, and Welfare in Japan.
Takanari Gotoda
The Research Committee for Primary Hyperlipidemia, Research on Measures for Intractable Diseases by the Ministry for Health, Labor, and Welfare in Japan.
Yutaka Kiyohara
The Research Committee for Primary Hyperlipidemia, Research on Measures for Intractable Diseases by the Ministry for Health, Labor, and Welfare in Japan.
Toshio Hayashi
The Research Committee for Primary Hyperlipidemia, Research on Measures for Intractable Diseases by the Ministry for Health, Labor, and Welfare in Japan.
Junji Kobayashi
The Research Committee for Primary Hyperlipidemia, Research on Measures for Intractable Diseases by the Ministry for Health, Labor, and Welfare in Japan.
Kazuaki Shimamoto
The Research Committee for Primary Hyperlipidemia, Research on Measures for Intractable Diseases by the Ministry for Health, Labor, and Welfare in Japan.
Hideaki Bujo
The Research Committee for Primary Hyperlipidemia, Research on Measures for Intractable Diseases by the Ministry for Health, Labor, and Welfare in Japan.
Shun Ishibashi
The Research Committee for Primary Hyperlipidemia, Research on Measures for Intractable Diseases by the Ministry for Health, Labor, and Welfare in Japan.
Koji Shirai
The Research Committee for Primary Hyperlipidemia, Research on Measures for Intractable Diseases by the Ministry for Health, Labor, and Welfare in Japan.
Shinichi Oikawa
The Research Committee for Primary Hyperlipidemia, Research on Measures for Intractable Diseases by the Ministry for Health, Labor, and Welfare in Japan.
Yasushi Saito
The Research Committee for Primary Hyperlipidemia, Research on Measures for Intractable Diseases by the Ministry for Health, Labor, and Welfare in Japan.
Nobuhiro Yamada
The Research Committee for Primary Hyperlipidemia, Research on Measures for Intractable Diseases by the Ministry for Health, Labor, and Welfare in Japan.

Keywords: Hyperlipidemia, Dyslipidemia, Triglyceridesl, HDL cholesterol, LDL cholesterol

JOURNAL OPEN ACCESS

2008 Volume 15 Issue 3 Pages 116-121

DOI https://doi.org/10.5551/jat.E560

Details

Abstract

The Japan Atherosclerosis Society (JAS) guidelines for the prevention of atherosclerotic diseases, proposing management for LDL cholesterol as the primary target, have successfully contributed to the prevention of cardiovascular events; however, recently, the impact of hypertriglyceridemia as an additional cardiovascular risk has become understood, especially in light of the rise in obesity, metabolic syndrome, and diabetes in the Japanese population. Rather than waiting to obtain conclusive domestic data confirming that hypertriglyceridemia is a cardiovascular risk factor and that its management is efficacious, we propose guidelines for hypertriglyceridemia using non-HDL cholesterol as a second target.

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