Effects of lifestyle advice provided by pharmacists on blood pressure: The COMmunity Pharmacists ASSist for Blood Pressure (COMPASS-BP) randomized trial

Hiroshi Okada; Mitsuko Onda; Masaki Shoji; Naoki Sakane; Yasushi Nakagawa; Takashi Sozu; Yui Kitajima; Ross T. Tsuyuki; Takeo Nakayama

doi:10.5582/bst.2017.01256

Original Articles

Effects of lifestyle advice provided by pharmacists on blood pressure: The COMmunity Pharmacists ASSist for Blood Pressure (COMPASS-BP) randomized trial

Hiroshi Okada, Mitsuko Onda, Masaki Shoji, Naoki Sakane, Yasushi Nakagawa, Takashi Sozu, Yui Kitajima, Ross T. Tsuyuki, Takeo Nakayama

Author information

Hiroshi Okada
Department of Health Informatics, Kyoto University School of Public Health
Division of Preventive Medicine, Clinical Research, National Hospital Organization, Kyoto Medical Center
EPICORE Centre, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta
Mitsuko Onda
Clinical Laboratory of Social and Administrative Pharmacy, Osaka University of Pharmaceutical Sciences
Masaki Shoji
Clinical Laboratory of Practical Pharmacy, Osaka University of Pharmaceutical Sciences, Osaka, Japan; 6 Polon Company
Naoki Sakane
Division of Preventive Medicine, Clinical Research, National Hospital Organization, Kyoto Medical Center
Yasushi Nakagawa
Polon Company
Takashi Sozu
Department of Information and Computer Technology, Faculty of Engineering, Tokyo University of Science
Yui Kitajima
Department of Management Science, Faculty of Engineering, Tokyo University of Science
Ross T. Tsuyuki
EPICORE Centre, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta
Takeo Nakayama
Department of Health Informatics, Kyoto University School of Public Health

Keywords: Community pharmacy, hypertension, home blood pressure measurement, patient education, mixed-effect model for repeated measures analysis

JOURNAL FREE ACCESS

2017 Volume 11 Issue 6 Pages 632-639

DOI https://doi.org/10.5582/bst.2017.01256

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Abstract

The COMmunity Pharamcists ASSist for Blood Pressure (COMPASS-BP) study aimed to assess the effectiveness of lifestyle support programs administered in community pharmacies on hypertension control. This open-label, two-armed parallel group, cluster-randomized controlled trial included 73 pharmacies (clusters) in Japan randomized to a control or intervention group. Eligible hypertensive patients (n = 125), aged 20-75 years, received the intervention (n = 64) or the control treatment (n = 61), as dictated by their pharmacy randomization. Patients in the intervention group received brochures and healthy lifestyle advice from pharmacists using motivational interviewing methods during pharmacy visits over a 12-week period, with their usual pharmacy care. Conversely, the control group just received usual care. The main outcome measure was a change in morning systolic blood pressure (SBP) from baseline to week 12. The intervention group exhibited a decrease in morning SBP that was 6.0 mmHg greater than that of the control group (95% confidence interval [CI]: −11.0 to −0.9, p = 0.021). In a mixed-effect model for repeated measures analysis, the intergroup difference in morning SBP decrease was −4.5 mmHg (95% CI: −8.5 to −0.6, p = 0.024). Our findings indicate that implementation of a lifestyle advice program in pharmacies is feasible and may lead to reduced blood pressure.

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