Clinical features of hypersensitivity reactions to oxaliplatin among Chinese colorectal cancer patients
Yang Zhao , Xin An , Xiao-Juan Xiang, Fen Feng , Feng-Hua Wang , Zhi-Qiang Wang , Rui-Hua Xu, You-Jian He, Yu-Hong Li
State Key Laboratory of Oncology in South China, Guangzhou, 510060, Guangdong, P. R. China. liyuhong@mail.sysu.edu.cn
[Abstract] Background and Objective: Oxaliplatin is one of the effective drugs for the treatment of advanced colorectal cancer(CRC). Oxaliplatin-induced allergic reactions in European and American patients have been reported but in China there are only a few case reports. This study was to investigate the incidence rate and characteristics of oxaliplatin-induced allergic reactions in Chinese CRC patients. Methods: Clinical data of 109 advanced CRC patients receiving oxaliplatin plus capecitabine(XELOX regimen) as first-line therapy were collected and analyzed retrospectively. Results: Of 109 patients, 13 (11.9%) had hypersensitivity. Of 546 cycles, 23 (4.2%) had hypersensitivity. Grade-I, -II, and -III reactions were seen in 13, 8, and 2 cycles, respectively； no Grade-IV reaction was observed. Allergic reactions usually occurred in the median time of fifth cycle (range, 1-8 cycles) of oxaliplatin-containing therapy, and the cumulative dose of oxaliplatin was 1200 mg (range, 400-1600 mg). The symptoms associated with anaphylaxis appeared between 5 min and 360 min (median, 180 min) after oxaliplatin infusion, and were relieved after withdrawal of the oxaliplatin infusion and treatment with antiallergic drugs. Eight patients continued to receive oxaliplatin therapy after prophylactically treatment with the antiallergic drugs, such as steroids, and 4 patients among them didn’t suffer from allergic reactions any more. Oxaliplatin-induced allergic reactions were more commonly seen in female patients than in male patients (P<0.05). Age, body surface area, performance status, tumor location, and pathologic type showed no significant difference in the patients with different allergic reaction. Conclusions: Oxaliplatin-induced allergic reactions also occurred in Chinese colorectal cancer patients, and the incidence rate, occurrence time, degree of severity, and clinical outcome were coincident with abroad literatures.
Chinese Journal of Cancer 2010, Volume: 29, Issue 1, Page: 96-
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