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2017, vol. 6, br. 1, str. 58-71
Antimikrobni sulfonamidni lekovi
Univerzitet u Nišu, Tehnološki fakultet, Leskovac, Srbija

e-adresaana.tacic@gmail.com
Sažetak
Sulfonamidi su prvi uspešno sintetisani antimikrobni lekovi. Mehanizam antimikrobnog delovanja sulfonamida uključuje kompetetivnu inhibiciju sinteze folne kiseline, čime se sprečava rast i razmnožavanje mikroorganizama. Usled ovakvog mehanizma delovanja, sulfonamidi pripadaju grupi bakteriostatika. Iako se primenjuju već više od 70 godina, i dalje postoje stanja i bolesti za čiju terapiju su sulfonamidi lekovi prvog izbora. Šira primena sulfonamida ograničena je bakterijskom rezistencijom i neželjenim efektima sulfonamida. Sulfonamidi i njihovi metaboliti se svrstavaju u grupu perzistentnih organskih zagađivača. Degradacija i uklanjanje sulfonamida iz životne sredine se može postići primenom različitih tehnika, kao što su oksidacione tehnike, u koje spadaju hlorovanje i napredni oksidacioni procesi, zatim adsorpcioni i membranski procesi, kao i kombinovani procesi. PR Projekat Ministarstva nauke Republike Srbije, br. TR 34012.
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O članku

jezik rada: engleski
vrsta rada: pregledni članak
DOI: 10.5937/savteh1701058T
objavljen u SCIndeksu: 29.06.2017.

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