posted on 2022-03-04, 12:50authored byXiaozhen HuangXiaozhen Huang, Nan Xiao, Yue Xie, Lingli Tang, Yueqin Zhang, Yuan Yu, Yiting Li, Cao Xu
Our study reveals a novel genetic canalization mechanism
enabled by heterotypic transcriptional condensates formed by paralogous protein
interactions and phase separation, uncovering the molecular link between gene
duplication caused IDR variation and robust transcriptional control of stem
cell fate transition.