CC-1065 (NSC-298223), A NEW ANTITUMOR ANTIBIOTIC
PRODUCTION, IN VITRO BIOLOGICAL ACTIVITY, MICROBIOLOGICAL ASSAYS AND TAXONOMY OF THE PRODUCING MICROORGANISM
1978 Volume 31 Issue 12 Pages 1211-1217
Details
1978 Volume 31 Issue 12 Pages 1211-1217
A new antitumor antibiotic is produced in fermentation liquors of Streptomyces zelensis sp.n. The antibiotic is biologically active at extremely low concentrations. At 40 pg/ml, it inhibited 90% of the growth of L1210 cells in culture in tube dilution assays. The minimal inhibitory concentrations against Gram-positive bacteria is between 1-10 ng/ml, while these values for Gram-negative bacteria and fungi are mostly under 1 μg/ml. A microbiological assay with Bacillus subtilis can detect concentrations of 1-2 ng/ml.
