CC-1065 (NSC 298223), A POTENT NEW ANTITUMOR AGENT IMPROVED PRODUCTION AND ISOLATION, CHARACTERIZATIONAND ANTITUMOR ACTIVITY

DAVID G. MARTIN; CAROLYN BILES; SHIRLEY A. GERPHEIDE; LADISLAV J. HANKA; WILLIAM C. KRUEGER; J. PATRICK MCGOVREN; STEPHEN A. MIZSAK; GARY L. NEIL; JULIANNA C. STEWART; JERONIMO VISSER

doi:10.7164/antibiotics.34.1119

CC-1065 (NSC 298223), A POTENT NEW ANTITUMOR AGENT

IMPROVED PRODUCTION AND ISOLATION, CHARACTERIZATIONAND ANTITUMOR ACTIVITY

DAVID G. MARTIN, CAROLYN BILES, SHIRLEY A. GERPHEIDE, LADISLAV J. HANKA, WILLIAM C. KRUEGER, J. PATRICK MCGOVREN, STEPHEN A. MIZSAK, GARY L. NEIL, JULIANNA C. STEWART, JERONIMO VISSER

Author information

DAVID G. MARTIN
Person to whom correspondence should be sent .
CAROLYN BILES
Research Laboratories, The Upjohn Company
SHIRLEY A. GERPHEIDE
Research Laboratories, The Upjohn Company
LADISLAV J. HANKA
Research Laboratories, The Upjohn Company
WILLIAM C. KRUEGER
Research Laboratories, The Upjohn Company
J. PATRICK MCGOVREN
Research Laboratories, The Upjohn Company
STEPHEN A. MIZSAK
Research Laboratories, The Upjohn Company
GARY L. NEIL
Research Laboratories, The Upjohn Company
JULIANNA C. STEWART
Research Laboratories, The Upjohn Company
JERONIMO VISSER
Research Laboratories, The Upjohn Company

JOURNAL FREE ACCESS

1981 Volume 34 Issue 9 Pages 1119-1125

DOI https://doi.org/10.7164/antibiotics.34.1119

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Abstract

( Received for publication June 15, 1981)CC-1065 (NSC 298223) is a potent new antitumor antibiotic with a unique structure produced by Streptomyces zelensis. Improved production, isolation, and assay methods are described along with physico-chemical properties and antitumor activity.

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