CALPHOSTINS, NOVEL AND SPECIFIC INHIBITORS OF PROTEIN KINASE C
II. CHEMICAL STRUCTURES
1989 Volume 42 Issue 10 Pages 1475-1481
Details
1989 Volume 42 Issue 10 Pages 1475-1481
The structures of new antitumor antibiotics, calphostins (UCN-1028) A, B, C, D and I, which are specific and potent inhibitors of protein kinase C, were determined by spectral and chemical studies. All of the antibiotics have a 3, 10-perylenequinone skeleton and calphostin D was revealed to be an antipode of isophleichrome.
