Bacillaene, a Novel Inhibitor of Procaryotic Protein Synthesis Produced by Bacillus subtilis: Production, Taxonomy, Isolation, Physico-chemical Characterization and Biological Activity

PRAMATHESH S. PATEL; STELLA HUANG; SUSAN FISHER; DOLORES PIRNIK; CAROL AKLONIS; LORETTA DEAN; EDWARD MEYERS; PRABHAVATHI FERNANDES; FRIEDRICH MAYERL

doi:10.7164/antibiotics.48.997

Bacillaene, a Novel Inhibitor of Procaryotic Protein Synthesis Produced by Bacillus subtilis:

Production, Taxonomy, Isolation, Physico-chemical Characterization and Biological Activity

PRAMATHESH S. PATEL, STELLA HUANG, SUSAN FISHER, DOLORES PIRNIK, CAROL AKLONIS, LORETTA DEAN, EDWARD MEYERS, PRABHAVATHI FERNANDES, FRIEDRICH MAYERL

Author information

PRAMATHESH S. PATEL
Department of Biomolecular Screening, Bristol-Myers Squibb Pharmaceutical Research Institute
STELLA HUANG
Department of Analytical Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute
SUSAN FISHER
Department of Biomolecular Screening, Bristol-Myers Squibb Pharmaceutical Research Institute
DOLORES PIRNIK
Department of Biomolecular Screening, Bristol-Myers Squibb Pharmaceutical Research Institute
CAROL AKLONIS
Department of Biomolecular Screening, Bristol-Myers Squibb Pharmaceutical Research Institute
LORETTA DEAN
Department of Biomolecular Screening, Bristol-Myers Squibb Pharmaceutical Research Institute
EDWARD MEYERS
Department of Biomolecular Screening, Bristol-Myers Squibb Pharmaceutical Research Institute
PRABHAVATHI FERNANDES
Department of Biomolecular Screening, Bristol-Myers Squibb Pharmaceutical Research Institute
FRIEDRICH MAYERL
Process and Research Development, Bristol-Myers Squibb Pharmaceutical Research Institute

JOURNAL FREE ACCESS

1995 Volume 48 Issue 9 Pages 997-1003

DOI https://doi.org/10.7164/antibiotics.48.997

Details

Abstract

Bacillaene, a novel polyene antibiotic, was discovered and isolated from fermentation broths of a strain of Bacillus subtilis. The novel antibiotic has a nominal molecular weight of 580 and an empirical formula of C₃₅H₄₈O₇. Bacillaene is active against a broad spectrum of bacteria in agar-plate diffusion assays. Studies in vitro indicate that the antibiotic inhibits prokaryotic protein synthesis but not eukaryotic protein synthesis. Cell survival studies performed with strains of Escherichia coli indicate that the antibiotic is a bacteriostatic agent.

Corresponding author

Register with J-STAGE for free!